Multisite assessment of the impact of a prenatal testing educational App on patient knowledge and preparedness for prenatal testing decision making

Winters, Patricia; Curnow, Kirsten J.; Benachi, Alexandra; Gil, M. M.; Santacruz, B.; Nishiyama, Miyuki; Hasegawa, Fuyuki; Sago, Haruhiko

doi:10.1007/s12687-022-00596-x

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…In addition to increasing the number of clinical geneticists, certified genetic counselors, and obstetricians/ gynecologists with GC training in prenatal genetic testing, it may be necessary to train midwives and obstetric nurses immediately to provide primary information of prenatal testing, considering the daily clinical workflow in obstetrics. In addition, the usefulness of software applications for a better understanding of NIPT has been demonstrated at the global level, 26 and it will be essential to utilize these technologies for GC in the near future.…”

Section: Discussionmentioning

confidence: 99%

Change in client choice under multiple prenatal genetic testing options including noninvasive prenatal testing (NIPT) after genetic counseling in a Japanese maternity hospital

Naruse

Pooh

Kyukawa³

et al. 2023

J of Obstet and Gynaecol

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ObjectiveThis study examined how clients' selection and preference for noninvasive prenatal testing (NIPT) for aneuploidy changed with genetic counseling (GC) performed by certified geneticists at a primary hospital specializing in obstetrics, where other multiple prenatal genetic tests options were available.MethodsA total of 334 couples who underwent GC between 2017 and 2019 were included in the study. The average age of the pregnant women who underwent GC was 35.1 years.ResultsAmong the 95 couples (28.4%) who wanted NIPT at the start of GC, 10 (10.5%) switched to other tests, and 4 (4.2%) chose not to undergo any test. Among the 106 (31.7%) couples who wanted the combination of ultrasonography and the serum marker test, 12 (11.3%) chose not to undergo the test. Among the 92 (27.5%) couples who were undecided before GC, 21 (22.8%) wanted NIPT, 31 (33.7%) selected combined tests, and 18 (19.6%) did not undergo any test.ConclusionWe have demonstrated the significance of GC before prenatal genetic testing under widespread use of NIPT. Ideally, obstetric facilities should provide GC, or at least, pre‐counseling at their own facilities, and offer multiple prenatal genetic testing options or refer to other facilities for the same.

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Section: Discussionmentioning

confidence: 99%

Change in client choice under multiple prenatal genetic testing options including noninvasive prenatal testing (NIPT) after genetic counseling in a Japanese maternity hospital

Naruse

Pooh

Kyukawa³

et al. 2023

J of Obstet and Gynaecol

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“…This result is consistent with previous studies conducted in developed countries. [14][15][16] The result underlines the importance of pretest genetic counseling for all pregnant women as this facilitates understanding before decision-making. Importantly, this study showed that having an animated educational video added yielded a stronger effect on increasing knowledge of the screening's performance and limitations than traditional counseling alone.…”

Section: Discussionmentioning

confidence: 99%

“…13 Reports from developed countries have found that various tools in prenatal genetic counseling, such as educational apps and videos as well as low literacy decision aids, can improve the knowledge of pregnant women who undergo cell-free DNA screening. [14][15][16] However, data are limited from Thailand and other developing countries where women have different baseline socio-educational backgrounds.…”

Section: Introductionmentioning

confidence: 99%

Effects of an animated educational video on knowledge of cell-free DNA screening among pregnant women: A randomized control trial

Nintao,

Manonai,

Wattanayingcharoenchai

et al. 2023

Preprint

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Background In middle-income developing countries, pregnant women had insufficient knowledge about cell-free DNA screening. Reports from developed countries have found that various tools in prenatal genetic counseling can improve the knowledge of pregnant women who undergo cell-free DNA screening. Data are limited from developing countries where women have different baseline socio-educational backgrounds. The objective of this study was to compare the effects of an animated educational video combined with traditional counseling versus traditional counseling alone in changing pregnant women’s knowledge of cell-free DNA screening. Methods This study was a randomized control trial at an antenatal clinic. Eligible subjects who were Thai pregnant women, were randomized to either view or not view the video explaining cell-free DNA screening. Both groups received traditional counseling. The women were asked to complete a questionnaire assessing knowledge of the screening before and after intervention. Primary outcome was the change in knowledge scores. Secondary outcomes were attitudes toward positive results, levels of satisfaction with counseling, and screening acceptance rates. Results Data from 83 women in the video group and 82 in the non-video group were analyzed. The knowledge score change after counseling was significantly higher in the video group than the non-video group (+ 7.1 ± 3.3 vs + 4.2 ± 2.5; p = 0.026). There were no significant differences in attitudes toward positive results (p = 0.187), levels of satisfaction (p = 0.28), or screening acceptance rates (p = 0.15) between the groups. Conclusions Adding the video to traditional counseling was better than traditional counseling alone in improving pregnant women’s knowledge about cell-free DNA screening.

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“…Women should not feel pressured but be enabled to make a decision based on their own beliefs. Therefore, it seems crucial to consider the development of standardised information in the form of booklets or online educational tools for patients [ 42 ]. This could facilitate access to detailed written information, in addition to verbal information provided during the consultation.…”

Section: Discussionmentioning

confidence: 99%

Health professionals and scientists’ views on genome-wide NIPT in the French public health system: Critical analysis of the ethical issues raised by prenatal genomics

Perrot

Horn²

2022

PLoS ONE

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In France, since January 2020, laboratories have started to make available genome-wide Non-Invasive Prenatal Testing (GW-NIPT) beyond the three common trisomies (T21, T13 and T18) at the same cost as standard NIPT. With the possible margins for interpretation of the legal framework and in the absence of clear and updated guidelines, health professionals are left with questions about which type of screening offer may be clinically responsible, morally appropriate, and, at the same time, respectful of women’s values and ability to make autonomous choices. The aim of this study is to provide an analysis and understanding of the challenging dimensions of clinical practices in the context of evolving scientific knowledge and techniques in prenatal genomics. In this article, we develop a critical analysis of the arguments and concerns that emerge around the offer of expanded NIPT and are discussed by health professionals and scientists. To achieve this, we conducted qualitative semi-structured interviews with 17 health professionals and scientists from September 2021 to February 2022 and a comprehensive literature review (regulatory, scientific, medical, institutional sources). The results of our empirical research highlight the importance of addressing ethical issues related to the differing quality of counselling, the complexity of achieving informed consent, and the avoidance of harm to pregnant women in the feedback of findings beyond T21, T18 and T13. If there is an increase in the provision of GW-NIPT within the French public health system, it will be essential to promote medical practices that respect reproductive choices of women, support their autonomous decision and their understanding of the limitations and uncertainties associated with GW screening. Further research is required to provide an insight into women’s perceptions in order to refine our analysis from the patients’ perspective.

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Multisite assessment of the impact of a prenatal testing educational App on patient knowledge and preparedness for prenatal testing decision making

Cited by 5 publications

References 30 publications

Change in client choice under multiple prenatal genetic testing options including noninvasive prenatal testing (NIPT) after genetic counseling in a Japanese maternity hospital

Change in client choice under multiple prenatal genetic testing options including noninvasive prenatal testing (NIPT) after genetic counseling in a Japanese maternity hospital

Effects of an animated educational video on knowledge of cell-free DNA screening among pregnant women: A randomized control trial

Health professionals and scientists’ views on genome-wide NIPT in the French public health system: Critical analysis of the ethical issues raised by prenatal genomics

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