Multiscale technologies for treatment of ischemic cardiomyopathy

Abstract

The adult mammalian heart possesses only limited capacity for innate regeneration and the response to severe injury is dominated by the formation of scar tissue. Current therapy to replace damaged cardiac tissue is limited to cardiac transplantation and thus many patients suffer progressive decay in the heart’s pumping capacity to the point of heart failure. Nanostructured systems have the potential to revolutionize both preventive and therapeutic approaches for treating cardiovascular disease. Here, we outline recent advancements in nanotechnology that could be exploited to overcome the major obstacles in the prevention of and therapy for heart disease. We also discuss emerging trends in nanotechnology affecting the cardiovascular field that may offer new hope for patients suffering massive heart attacks.

Gut microbiota and cardiovascular disease: opportunities and challenges

“…Although nanomedicine has shown a considerable and growing capacity for the diagnosis and treatment of CAD [250], its application in the modulation of gut microbiota that can affect CAD development is still under investigation. Very recently, we proposed several nanotechnologybased strategies to control gut microbiota composition [251].…”

Effect of Intramyocardial Grafting Collagen Scaffold With Mesenchymal Stromal Cells in Patients With Chronic Ischemic Heart Disease

“…However, the cell delivery techniques used thus far have all been fraught with poor efficiency 8 and have led to poor engraftment, retention, and survival of transplanted cells in heart tissue. 9 …”

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

“…Cardiac tissue engineering is particularly one of the fields in tissue engineering and regenerative medicine that has been revolutionized through nanostructured systems since they have solutions for both preventive and therapeutic approaches to treat CVD. 14 In cardiac tissue engineering, to select the appropriate scaffold, some key parameters need to be determined, such as material composition, surface characteristics, mechanical properties, biocompatibility, degradation rate, and cell seeding conditions. It has been discussed in some review articles 16,[18][19][20][21] that the ideal scaffold for cardiac tissue engineering would be the one that combines the following characteristics: (i) appropriate mechanical properties that match the native cardiac tissue (anisotropy, elasticity, contractility, etc.…”