BackgroundOsteosarcoma is a high malignant neoplasm, and conflicting findings have been reported on the survival and function recovery of osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared limb salvage surgery (LSS) with amputation in clinical outcomes of osteosarcoma patients by a meta-analysis.MethodsThe survival rate of osteosarcoma patients was collected from research reports from CNKI, MEDLINE, EMBASE, the Cochrane Database, and Google Scholar till April 30, 2016. The quality of including articles was evaluated by two independent reviewers. Differences between patients undergoing limb salvage surgery and amputation were analyzed based on postoperative survival rates.ResultsTen articles were included according to selection criteria. There were 1343 patients in total from these studies. Our results showed that there was no significant difference between limb salvage surgery and amputation according to local recurrence; however, patients with limb salvage surgery had a higher 5-year overall survival.ConclusionsLSS results in higher 5-year survival rates and better survival, while not increasing the risk of local recurrence. This study provided more evidences to support limb salvage surgery as a considerable treatment of osteosarcoma patients.

This randomized clinical trial evaluates the safety and feasibility of a collagen gel vehicle for mesenchymal stromal cell treatment, compared with cell treatment alone and no cell treatment, in patients with chronic ischemic heart disease undergoing coronary artery bypass grafting.

It was pointed out recently that supersymmetry can generate flavor-changing gluonic dipole operators with sufficiently large coefficients to dominate the observed value of ⑀Ј/⑀. We point out that the same operators contribute to direct CP violation in hyperon decay and can generate a CP violating asymmetry A(⌳ Ϫ 0 ) in the range probed by the current E871 experiment. Interestingly, models that naturally reproduce the relation ϭͱm d /m s do not generate ⑀Ј/⑀ but could lead to an A(⌳ Ϫ 0 ) of O(10 Ϫ3 ).The origin of CP violation remains one of the outstanding problems in particle physics. Until recently the only observation of CP violation was in the neutral kaon mixing, with a value of ⑀Ϸ2.27ϫ10 Ϫ3 exp(i/4) ͓1,2͔. The KTeV and NA48 Collaborations have now reported observations of direct CP violation in the neutral kaon decay amplitudes ͓3͔, with the world average value being Re(⑀Ј/⑀)ϭ(21.2Ϯ4.6) ϫ10 Ϫ4 ͓4͔.Although this result is not inconsistent with the standard model prediction, it can be used to constrain other models of CP violation ͓5-7͔. In particular, it has been found that there can be large supersymmetric contributions to ⑀Ј/⑀ ͓5,6͔. Depending on which new contributions are large, there are different consequences for other processes such as rare kaon decays ͓8͔ and hyperon decays.In this Rapid Communication we concentrate on the supersymmetric scenario in which the gluonic dipole operators can have large coefficients. In this case there are potentially large contributions to both ⑀Ј/⑀ ͓5͔ and to the CP-violating asymmetry A(⌳ Ϫ 0 ) in hyperon nonleptonic decays. Experiment E871 at Fermilab is expected to reach a sensitivity of 2ϫ10 Ϫ4 for the observable ͓A(⌳ Ϫ 0 )ϩA(⌶ Ϫ Ϫ )͔ ͓9͔. The CP-violating asymmetry A(⌳ Ϫ 0 ) compares the decay parameter ␣ from the reaction ⌳ 0 →p Ϫ to the corresponding parameter ␣ in ⌳ 0 →p ϩ whereas A(⌶ Ϫ Ϫ ) is the corresponding asymmetry for the mode ⌶ Ϫ →⌳ 0 Ϫ . These asymmetries have a very simple form when one neglects the small ⌬Iϭ3/2 amplitude, for example ͓10͔,where ␦ 1 ϭ6°, ␦ 11 ϭϪ1.1°are the final state N interaction phases for S and P wave amplitudes with Iϭ1/2, respectively ͓11͔. s,p are the corresponding CP-violating weak phases. Recent calculations suggest that the strong scattering phases in the ⌳ 0 final state of the ⌶ decay are small ͓12͔, and, therefore, the current theoretical prejudice is that ͉A(⌳ Ϫ 0 )͉ will dominate the measurement. The standard model prediction for this quantity is around 3ϫ10 Ϫ5 , albeit with large uncertainty ͓10,13͔. This suggests that a nonzero measurement by E871 will be an indication for new physics.A model independent study of new CP-violating interactions has shown that A(⌳ Ϫ 0 ) could be ten times larger than in the standard model and within reach of E871 ͓14͔. A particular example of an operator in which A(⌳ Ϫ 0 ) can be this large is precisely the gluonic dipole operator ͓14͔. The results of E871, therefore, can have a direct impact on supersymmetric models.The short distance effective Hamiltonian for the gluonic dipole operator...

We consider the recent LHCb result for B c → J/ψτ ν in conjunction with the existing anomalies in R(D) and R(D ) within the framework of a right-handed current with enhanced couplings to the third generation. The model predicts a linear relation between the observables and their SM values in terms of two combinations of parameters. The strong constraints from b → sγ on W −W mixing effectively remove one of the combinations of parameters resulting in an approximate proportionality between all three observables and their SM values. To accommodate the current averages for R(D) and R(D ), the W mass should be near 1 TeV, and possibly accessible to direct searches at the LHC. In this scenario we find that R(J/ψ) is enhanced by about 20% with respect to its SM value and about 1.5σ below the central value of the LHCb measurement. The predicted dΓ/dq 2 distribution for B → D(D )τ ν is in agreement with the measurement and the model satisfies the constraint from the B c lifetime.