Multiresidue analysis of 88 polar organic micropollutants in ground, surface and wastewater using online mixed-bed multilayer solid-phase extraction coupled to high performance liquid chromatography–tandem mass spectrometry

Huntscha, Sebastian; Singer, Heinz; McArdell, Christa S.; Frank, Carolin E.; Hollender, Juliane

doi:10.1016/j.chroma.2012.10.032

Cited by 214 publications

(118 citation statements)

References 47 publications

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“…187 Mais recentemente, com a possibilidade de se fazer a extração em linha com a determinação por LC-MS/MS, técnica denominada SPE on line, houve uma redução significativa no tempo de análise e quantidade de solventes empregados no preparo de amostras. 28,188,189 Além da SPE, outras técnicas de preparo de amostras também são utilizadas para a determinação de micropoluentes no ambiente, por exemplo, a microextração em fase sólida (SPME), que faz uso de uma fibra de material sorvente para a extração dos compostos por imersão ou por headspace; a QuECheRS (do inglês, Quick, Easy, Cheap, Effective, Ruged and Safe), que utiliza como etapa inicial a extração por um solvente (originalmente acetonitrila), em seguida adição de sais e separação de fase, etapa de limpeza (clean up) e adição de padrão interno para posterior determinação dos analitos; dentre outras técnicas. [190][191][192][193] Concomitantemente com a otimização das técnicas analíticas, foram desenvolvidos e aprimorados diferentes bioensaios (os quais utilizam organismos vivos para avaliar um efeito de uma substância ao qual foram expostos por um período conhecido de tempo) como ferramentas capazes de fornecer informações adicionais aos ensaios ecotoxicológicos, sobre os efeitos estrogênicos, androgênicos, de sinergismo ou influências antiestrogênicas relacionadas à presença de inúmeros contaminantes em uma amostra complexa.…”

Section: O Aspecto Regulatóriounclassified

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

2017

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publicado na web em 11/07/2017 EMERGING CONTAMINANTS IN AQUATIC MATRICES FROM BRAZIL: CURRENT SCENARIO AND ANALYTICAL, ECOTOXICOLOGICAL AND LEGISLATIONAL ASPECTS. Emerging contaminants occur in parts per trillion or less in aquatic matrices. The effects related to the exposure of aquatic biota and human to them have been identified for different compounds. The knowledge about the concentrations of the exposure is the first step to perform risk assessments. The present work describes a literature review about occurrence in Brazilian aquatic matrices, and a discussion about biological effects, legislation and analytical aspects involving the presence of emerging compounds. The review includes 58 papers published between 1997 and 2016, considering the occurrence of personal care and pharmaceutical compounds, illicit drugs, hormones, pesticides and some other endocrine disruptors compounds in the matrices sewage, surface, ground and drinking waters. The concentrations varied from ng L -1 to μg L -1 , depending on the region and the compound. However, the contamination scenario was aggravated by the combination of poor sanitation status -such as low investment in sewage treatment plants, which led to an expressive contamination of the receiving waters with sewage -and the current goods consumption level, which is similar to that of developed countries. These data provide a good insight into the particular levels of contamination and can be used both for further researches and decision making in the regulation area of public policy.Keywords: emerging contaminants; endocrine disruptors compounds; drinking water; surface water; wastewater. CONTAMINANTES EMERGENTESA temática dos contaminantes emergentes ganhou destaque na década passada e vem sendo abordada em diferentes aspectos por pesquisadores do mundo todo. Tratam-se de centenas de compostos que têm sido detectados nos diferentes compartimentos ambientais (solo, água e ar), sendo eles tanto de origem antrópica (presentes em efluentes domésticos, industriais, hospitalares e aqueles provenientes das atividades agrícola e pecuária), quanto de ocorrência natural (presentes em diferentes espécies de plantas, por exemplo). Estes compostos podem apresentar algum risco ao ecossistema e eles não estão incluídos nos programas de monitoramento de rotina, ou seja, não são legislados. Assim, serão candidatos a uma futura regulamentação dependendo dos resultados obtidos em estudos de ecotoxicidade, efeitos à saúde humana, potencial de bioacumulação, transporte e destino nos diferentes compartimentos ambientais, além da quantidade em que são lançados e, portanto, da concentração no ambiente. Tratam-se de estudos que envolvem diferentes áreas da ciência e que têm sido considerados fundamentais para o esclarecimento dos novos paradigmas relacionados ao estilo de vida moderno. Conhecer os riscos associados à exposição por centenas de novos compostos que ainda não estão contemplados nas legislações vigentes permite antecipar e mitigar sérios danos para as gerações futuras.Muitos dos e...

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Section: O Aspecto Regulatóriounclassified

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

2017

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“…Traditional offline SPE is increasingly replaced with online SPE or with largevolume injection (LVI) prior to LC (Huntscha et al 2012). Online SPE reduces the time required for the extraction.…”

Section: Extractionmentioning

confidence: 99%

Refractory organic pollutants and toxicity in pulp and paper mill wastewaters

Lindholm‐Lehto

Knuutinen

Ahkola

et al. 2015

Environ Sci Pollut Res

134

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“…Extraction from water samples has usually been performed by off-line SPE [5,6,8,9,11], although on-line SPE-LC has also been reported as a time and cost-saving alternative thanks to its fully automation [7,13]. Large-volume injection (LVI) is an attractive approach for aqueous samples that has been applied in several works as a rapid and efficient alternative to conventional SPE [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Fast determination of 40 drugs in water using large volume direct injection liquid chromatography–tandem mass spectrometry

Boix

Ibáñez

Sancho

et al. 2015

Talanta

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This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse. The water samples were analyzed by ultrahigh-performance liquid chromatography coupled to hybrid triple quadrupole mass spectrometer (UHPLC-MS/MS QqQ). Taking profit of the increasing sensitivity of nowadays's tandem mass spectrometers, direct sample injection of large volumes has been an attractive alternative to pre-concentration steps. In this work, the developed methodology has been validated at three concentration levels (10, 100 and 1000 ng/L) in 10 different water samples of different types (5 effluent wastewaters and 5 surface waters). The majority of compounds could be satisfactory validated at these concentrations, showing good recoveries and precision. With only few exceptions, the limits of quantification (LOQs), estimated from the sample chromatogram at lowest spiked level tested, were below 3 ng/L. The method was applied to the analysis of 10 effluent wastewaters and 10 surface water samples. Venlafaxine was the compound most frequently detected (80%) in surface water, followed by acetaminophen (70%). Regarding effluent wastewater, valsartan and 4-acetyl aminoantipyrine were detected in 9 out of 10 samples analyzed. These two compounds together with 4-formyl aminoantipyrine and naproxen showed the highest concentrations (>2000 ng/L). In these cases, a dilution step was required for a correct quantification. As an additional evaluation of the method performance, the same water samples were analyzed in other laboratory by a second analytical methodology, based on on-line solid-phase-extraction coupled to LC-MS/MS (QqQ). KeywordsDirect injection, illicit drugs of abuse, pharmaceuticals, effluent wastewater, surface water, liquid chromatography, triple quadrupole mass spectrometry.

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Multiresidue analysis of 88 polar organic micropollutants in ground, surface and wastewater using online mixed-bed multilayer solid-phase extraction coupled to high performance liquid chromatography–tandem mass spectrometry

Cited by 214 publications

References 47 publications

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

Refractory organic pollutants and toxicity in pulp and paper mill wastewaters

Fast determination of 40 drugs in water using large volume direct injection liquid chromatography–tandem mass spectrometry

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