Multipotentiality of skin‐derived precursors: application to the regeneration of skin and other tissues

Abstract

Skin-derived precursors (SKPs) have been described as multipotent dermal precursors. Here, we provide a review of the breadth and depth of scientific literature and studies regarding SKPs, accounting for a large number of scientific publications. Interestingly, these progenitors can be isolated from embryonic and adult skin, as well as from a population of dermal cells cultured in vitro in monolayer. Gathering information from different authors, this review explores different aspects of the SKP theme, such as the potential distinct origins of SKPs in rodents and in humans, and also their ability to differentiate in vitro and in vivo into multiple lineages of different progeny. This remarkable capacity makes SKPs an interesting endogenous source of precursors to explore in the framework of experimental and therapeutic applications in different domains. SKPs are not only involved in the skin's dermal maintenance and support as well as wound healing, but also in hair follicle morphogenesis. This review points out the interests of future researches on SKPs for innovative perspectives that may be helpful in many different types of scientific and medical domains. exp erimentations en cours et a venir concernant les SKPs en vue de perspectives innovantes pouvant influencer la recherche dans de nombreux domaines scientifiques et m edicaux.

Photobiomodulation therapy for hair regeneration: A synergetic activation of β-CATENIN in hair follicle stem cells by ROS and paracrine WNTs

“…These findings suggested that WNTs play an important role in regulating hair regeneration. SKPs have been described as pluripotent dermal precursors involved in the hair cycle process ( Bergeron et al., 2019 ). However, it is unclear how SKPs participate in the hair cycle.…”

Inflammation Alters the Secretome and Immunomodulatory Properties of Human Skin-Derived Precursor Cells

“…These cells therefore not only represent promising candidates for future autologous therapy, but also for allogeneic cell-based off-the-shelf applications. Their translational potential is being investigated in preclinical animal models of spinal cord injury [7,24], bone repair [8] and wound healing [25][26][27][28]. In many of these degenerative diseases, however, a pronounced inflammatory microenvironment is present [29][30][31] that might increase the immunogenicity of SKP, facilitate their rejection and thus hamper their future therapeutic application.…”

Development and In Vitro Differentiation of Schwann Cells

“…They can be derived from adult rodent and human dermis, by culturing as floating spheres with bFGF and EGF, similarly to the neurosphere induction method described above [ 222 , 274 ]. These cells can be of mesenchymal or neural crest origin, depending on the exact structure they were harvested from [ 275 , 276 ], but either of them can be differentiated into a Schwann cell phenotype. The first dedicated protocols to generate Schwann cells from skin-derived neurospheres used incubation with the differentiation factors forskolin, Nrg1, and FBS in adherent cultures, and purification by manual picking of colonies [ 221 , 277 ] ( Table 4 ).…”