Multiply charged carbon-ion production for medical application

Kitagawa, A.; Muramatsu, M.; Sasaki, N.; Takasugi, W.; Wakaisami, S.; Biri, S.; Drentje, A.G.

doi:10.1063/1.2832361

Cited by 5 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical use of carbon ions for radiotherapy in the near future is planned for other sites as well. Since 1994, over 3,000 cancer patients have been treated by heavy ions produced by the HIMAC accelerator, and the results have established that carbon ions are one of the most effective radiations for radiotherapy (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…Several different types of heavy ions have been used in the clinic for cancer therapy (14). Carbon ions have been generated for use in clinical radiotherapy by the BEVALAC accelerator in Berkeley, CA, USA (14), the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences in Japan (15,16) and the GSI SIS accelerator in Darmstadt, Germany (17). The clinical use of carbon ions for radiotherapy in the near future is planned for other sites as well.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

2011

View full text Add to dashboard Cite

Abstract. The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent high-mass, high atomic number (Z) and high-energy particles known as HZE particles, as well as γ-rays. The survival of the irradiated cells was determined by a clonogenic survival assay. The yield of colonies growing in soft agar was used as a surrogate endpoint biomarker for transformation in vitro. The results showed that HZE particles and γ-ray radiations are effective in increasing the yield of anchorage-independent colonies. Based on the relative biological effectiveness (RBE) values in the clonogenic survival assays, 0.3-GeV/n carbon ions and 1-GeV/n iron ions were 2.9 and 2.4 times, respectively, as effective as γ-rays at killing the irradiated HTori-3 cells. At a dose of 200 cGy, 0.3-GeV/n carbon ions and 1-GeV/n iron ions were found to be 3.5 and 7.3 times, respectively, as effective as γ-rays at inducing anchorage-independent growth. These results suggest that the carcinogenic potential of 0.3-GeV/n carbon ions, as represented by the ability to induce anchorageindependent growth, may be lower than that of 1-GeV/n iron ions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

2011

View full text Add to dashboard Cite

show abstract

Diagnostics of a spark-discharge coupled to laser aluminum plasma by optical emission spectroscopy and ion time-of-flight

Rahman

Balki

Elsayed-Ali

2019

Optics & Laser Technology

View full text Add to dashboard Cite

MIVOC method with temperature control

Takasugi

Wakaisami

Sasaki

et al. 2010

Review of Scientific Instruments

View full text Add to dashboard Cite

The Heavy Ion Medical Accelerator in Chiba at the National Institute of Radiological Sciences has been used for cancer therapy, physics, and biology experiments since 1994. Its ion sources produce carbon ion for cancer therapy. They also produce various ions (H(+)-Xe(21+)) for physics and biology experiments. Most ion species are produced from gases by an 18 GHz electron cyclotron resonance ion source. However, some of ion species is difficult to produce from stable and secure gases. Such ion species are produced by the sputtering method. However, it is necessary to reduce material consumption rate as much as possible in the case of rare and expensive stable isotopes. We have selected "metal ions from volatile compounds method" as a means to solve this problem. We tested a variety of compounds. Since each compound has a suitable temperature to obtain the optimum vapor pressure, we have developed an accurate temperature control system. We have produced ions such as (58)Fe(9+), Co(9+), Mg(5+), Ti(10+), Si(5+), and Ge(12+) with the temperature control.

show abstract

Multiply charged carbon-ion production for medical application

Cited by 5 publications

References 9 publications

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

Diagnostics of a spark-discharge coupled to laser aluminum plasma by optical emission spectroscopy and ion time-of-flight

MIVOC method with temperature control

Contact Info

Product

Resources

About