Multiplicity of Quorum Quenching Enzymes: A Potential Mechanism to Limit Quorum Sensing Bacterial Population

Koul, Shikha; Kalia, Vipin Chandra

doi:10.1007/s12088-016-0633-1

Cited by 47 publications

(12 citation statements)

References 43 publications

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“…Pathogenicity of these bacteria such as Aeromonas hydrophila, A. salmonicida, Vibrio anguillarum, V. harveyi, Yersinia ruckeri and Tenacibaculum maritimum is mediated by quorum sensing systems that are important for biofilm formation [95]. The use of quorum quenching enzymes has also been successful in reducing pathogenicity of these pathogens [96][97][98]. Bacteria derived from fish microbiome have also been shown to produce natural products that inhibit formation of biofilms and therefore promote detachment of gram-negative pathogens [50].…”

Section: Conclusion and Future Perspectives: Towards Applied Researchmentioning

confidence: 99%

Fish Gut Microbiome: Current Approaches and Future Perspectives

et al. 2018

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In recent years, investigations of microbial flora associated with fish gut have deepened our knowledge of the complex interactions occurring between microbes and host fish. The gut microbiome not only reinforces the digestive and immune systems in fish but is itself shaped by several host-associated factors. Unfortunately, in the past, majority of studies have focused upon the structure of fish gut microbiome providing little knowledge of effects of these factors distinctively and the immense functional potential of the gut microbiome. In this review, we have highlighted the recently gained insights into the diversity and functions of the fish gut microbiome. We have also delved on the current approaches that are being employed to study the fish gut microbiome with an aim to collate all the knowledge gained and make accurate conclusions for their application based perspectives. The literature reviewed indicated that the future research should shift towards functional microbiomics to improve the maximum sustainable yield in aquaculture.

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Section: Conclusion and Future Perspectives: Towards Applied Researchmentioning

confidence: 99%

Fish Gut Microbiome: Current Approaches and Future Perspectives

et al. 2018

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“…Comparative genome analysis has revealed the presence of several copies of genes encoding AHL acylases and AHL lactonases in Pseudomonas spp. and Bacillus spp., respectively [62]. Studies have also revealed remarkable biodiversity and polymorphism in genes of AHL lactonases in Bacillus spp.…”

Section: Strategies To Control Biofilm Growthmentioning

confidence: 99%

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

et al. 2018

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Biofilm is a mode of living employed by many pathogenic and environmental microbes to proliferate as multicellular aggregates on inert inanimate or biological substrates. Several microbial diseases are associated with biofilms that pose challenges in treatment with antibiotics targeting individual cells. Bacteria in biofilms secrete exopolymeric substances that contribute to architectural stability and provide a secure niche to inhabiting cells. Quorum sensing (QS) plays essential roles in biofilm development. Pathogenic bacteria in biofilms utilize QS mechanisms to activate virulence and develop antibiotic resistance. This review is a brief overview of biofilm research and provides updates on recent understandings on biofilm development, antibiotic resistance and transmission, and importance of QS mechanisms. Strategies to combat biofilm associated diseases including anti-biofilm substances, quorum quenching molecules, bio-surfactants and competitive inhibitors are briefly discussed. The review concludes with updates on recent approaches utilized for biofilm inhibition and provides perspectives for further research in the field.

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“…Considering this, in conjunction with biofilm resistance to conventional drugs, alternative treatments for dental caries are stimulated. Accordingly, the use of some quorum-sensing (QS) molecules as antimicrobials has been reported [11][12][13][14]. These molecules regulate gene expression, cellular differentiation, and other functions [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, the use of some quorum-sensing (QS) molecules as antimicrobials has been reported [11][12][13][14]. These molecules regulate gene expression, cellular differentiation, and other functions [11][12][13][14][15]. Among the QS molecules, farnesol, an acyclic alcohol secreted by Candida species such as C. albicans and C. dubliniensis [16], has received attention for presenting antibiofilm activity.…”

Section: Introductionmentioning

confidence: 99%

Virulence Factors in Candida albicans and Streptococcus mutans Biofilms Mediated by Farnesol

et al. 2018

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The aim of this study was to evaluate the effect of farnesol on the production of acids and hydrolytic enzymes by biofilms of and. The present study also evaluated the time-kill curve and the effect of farnesol on matrix composition and structure of single-species and dual-species biofilms. Farnesol, at subinhibitory concentrations, showed a significant reduction in biofilm acid production, but did not alter hydrolytic enzyme production. The number of cultivable cells of both microorganisms was significantly reduced after 8 h of contact with farnesol. Extracellular matrix protein content was reduced for biofilms formed in the presence of farnesol. In addition, confocal laser scanning and scanning electron microscopy displayed structural alterations in all biofilms treated with farnesol, which included reduction in viable cells and extracellular matrix. In conclusion, farnesol showed favorable properties controlling some virulence factors of and biofilms. These findings should stimulate further studies using this quorum-sensing molecule, combined with other drugs, to prevent or treat biofilm-associated oral diseases.

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Multiplicity of Quorum Quenching Enzymes: A Potential Mechanism to Limit Quorum Sensing Bacterial Population

Cited by 47 publications

References 43 publications

Fish Gut Microbiome: Current Approaches and Future Perspectives

Fish Gut Microbiome: Current Approaches and Future Perspectives

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

Virulence Factors in Candida albicans and Streptococcus mutans Biofilms Mediated by Farnesol

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