Multiplex surface-enhanced Raman scattering detection of deoxynivalenol and ochratoxin A with a linear polymer affinity agent

Abstract

A linear, methacrylamide polymer affinity agent was explored to capture two mycotoxins, deoxynivalenol (DON) and ochratoxin A (OTA), for multiplex surface-enhanced Raman scattering (SERS) detection. These mycotoxins are naturally occurring...

Ceftriaxone sodium degradation by carbon quantum dots (CQDs)-decorated C-doped α-Bi2O3 nanorods

“…To reveal the photocatalytic degradation pathways of ceftriaxone sodium using CBO/CQDs, the DFT calculation and LC-MS analysis were conducted. Based on Fukui function, the DFT calculation can predict the regioselectivity of reactive species to attack the ceftriaxone sodium molecules and the formed intermediates [ 71 ]. According to the radical trapping experiments ( Fig.…”

Advancing Mycotoxin Detection in Food and Feed: Novel Insights from Surface‐Enhanced Raman Spectroscopy (SERS)

“…Most SERS methodologies report an analysis time between 2 and 24 h. For example, Rodriguez et al performed two incubations totaling 24 h before detecting DON and OTA using PAA and FON. [111] Thus, the likelihood for this technique to be implemented on-site is less, than those reporting shorter turnaround times. Additionally, Chen et al employed a pre-etched nanocluster to detect AFB 1 in peanut oil.…”

“…DON and OTA were detected at 1 mg kg −1 and 5 µg kg −1 , respectively, both individually and simultaneously and were visibly distinguishable without chemometric analysis. [ 111 ] This work highlights the importance of surface functionalization to help facilitate binding interactions with the nanomaterial surface and improve detection sensitivity, selectivity, and reproducibility, particularly when chemometrics are not being exploited.…”

Recent Advances in the Development and Characterization of Electrochemical and Electrical Biosensors for Small Molecule Neurotransmitters

“…36 Unlike antibodies, enzymes, and aptamers, polymers tend to be much less specific to their target analyte, which can allow for multiplex detection, though can make differentiation of different analytes difficult. 37 The principles of these polymer-based sensors are transferrable to electronic sensing methods and lead to a promising new direction for neurotransmitter detection. Though not a true biorecognition element, conducting polymers have shown utility in electrochemical sensing of neurotransmitters.…”

“…Polymers have not been broadly exploited in the field of electronic biosensing; however, robust detection schemes for small biomolecules using optical sensing platforms have been developed with polymer affinity agents . Unlike antibodies, enzymes, and aptamers, polymers tend to be much less specific to their target analyte, which can allow for multiplex detection, though can make differentiation of different analytes difficult . The principles of these polymer-based sensors are transferrable to electronic sensing methods and lead to a promising new direction for neurotransmitter detection.…”