Multiple tumors of the major salivary glands

Turnbull, A. D.; Frazell, Edgar L.

doi:10.1016/0002-9610(69)90230-x

Cited by 107 publications

(39 citation statements)

References 6 publications

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“…The incidence of a primary (untreated) multifocal parotid pleomorphic adenoma has been estimated at 0.14-0.6% [2,6,7,15]. Enroth [6] showed an incidence of 0.6% but all of those cases had undergone prior fine needle aspiration.…”

Section: Discussionmentioning

confidence: 99%

Primary Unilateral Multifocal Pleomorphic Adenoma of the Parotid Gland: Molecular Assessment and Literature Review

Miliauskas

Hunt

2008

Head and Neck Pathol

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Multiple separate tumors developing in a single salivary gland is rare in previously untreated patients. Tumors that can be multicentric include Warthin tumor, oncocytoma, basal cell adenoma and acinic cell carcinoma. The incidence of multiple primary unilateral pleomorphic adenomas is extremely rare in patients with no prior history of trauma or surgery. We report two cases of primary multicentric pleomorphic adenoma and review the literature. We also subjected one of our cases to a molecular clonality test. The molecular results suggested that the separate nodules were clonally related, arguing against an independent origin.Keywords Pleomorphic adenoma Á Multifocal Á Parotid gland Materials and MethodsThe computerized files of Clinpath Laboratories were searched for cases diagnosed as primary parotid pleomorphic adenoma or mixed tumor over a 10-year period, 1995-2004. A total of 210 cases were identified. Cases with a solitary tumor nodule were excluded and patients who had prior treatment or trauma were excluded. There was one case of a multifocal primary pleomorphic adenoma. A second case was seen in consultation. In each case hematoxylin and eosin (H&E)-stained slides were reviewed to confirm the diagnosis. Clinical case records were reviewed. A paraffin block was available for clonality studies from the non-referred case.

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Section: Discussionmentioning

confidence: 99%

Primary Unilateral Multifocal Pleomorphic Adenoma of the Parotid Gland: Molecular Assessment and Literature Review

Miliauskas

Hunt

2008

Head and Neck Pathol

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“…Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous [3, 24-27, 29, 31, 39, 43] and four metachronous [28,32,40,43]). Levin et al [25] recorded three additional unpublished cases of bilateral acinic cell adenocarcinoma of parotid, without commenting on temporality and reported a rate of bilaterality as high as 3%.…”

Section: Discussionmentioning

confidence: 99%

“…Levin et al [25] Millar et al [39] Chong et al [24] Turnbull and Frazell [43] MucoEp-MucoEp Habuka and Hyodo [35] Catania et al [23] AdenoCa-AdenoCa…”

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Multiple Malignant Salivary Gland Neoplasms: Mucoepidermoid Carcinoma of Palate and Adenoid Cystic Carcinoma of Floor of Mouth

Whitt

Schafer²,

Callihan³

2007

Head and Neck Pathol

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Salivary gland tumors usually occur as single lesions. To have more than one tumor is unusual. We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years. The patient later succumbed to non-Hodgkin lymphoma at age 72 years. There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature. Multiple malignant tumors of the same histologic type are more common than those of different histologic type. Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous). All involved the parotid glands bilaterally with the exception of one case that involved parotid and submandibular gland. Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands. Individuals with a history of malignancy are at risk for the development of additional malignant tumors and should receive appropriate clinical follow-up.

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“…Th e occurrence of multiple salivary gland tumors with diff erent histological characteristics is extremely rare. Th e most common coexistence is pleomorphic adenoma and Warthin's tumor (1,4). We present a patient with two diff erent tumors localized in the parotid gland and parapharyngeal area.…”

Section: Introductionmentioning

confidence: 99%

Two synchronous and different salivary gland tumors located in the parotid gland and parapharyngeal region: a case report

Kefeli¹,

Akpolat²,

Çengel³

et al. 2009

TJPATH

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A 58-year-old male patient with a mass in the left side of the neck for 3 months was admitted to hospital. Physical examination revealed two masses; a mobile, painless, left jugular mass (lymphadenopathy?) and a parapharyngeal mass behind the left tonsilla palatina. Computed tomography examination of the cervical region and pharynx demonstrated two soft tissue masses. Th e fi rst mass was in the left parapharyngeal region and about 3.5x3x3 cm in dimensions. Th is mass was well-circumscribed and showed heterogeneous contrast uptake. Th e second one was 4.5x2.5x2 cm, sharply delineated and homogeneous. It was partly embedded in the caudal region of the left parotid gland. Th e initial clinical diagnosis was a probable metastatic malignant tumor. Fine needle aspiration was done for the

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Multiple tumors of the major salivary glands

Cited by 107 publications

References 6 publications

Primary Unilateral Multifocal Pleomorphic Adenoma of the Parotid Gland: Molecular Assessment and Literature Review

Primary Unilateral Multifocal Pleomorphic Adenoma of the Parotid Gland: Molecular Assessment and Literature Review

Multiple Malignant Salivary Gland Neoplasms: Mucoepidermoid Carcinoma of Palate and Adenoid Cystic Carcinoma of Floor of Mouth

Two synchronous and different salivary gland tumors located in the parotid gland and parapharyngeal region: a case report

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