Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language

Nishio, Yoshiyuki; Hashimoto, Mamoru; Ishii, Kazunari; Ito, Daisuke; Mugikura, Shunji; Takahashi, Satoshi; Mori, Etsuro

doi:10.1016/j.neuropsychologia.2013.11.025

Cited by 45 publications

(31 citation statements)

References 67 publications

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“…Compared with the healthy group, all neuropsychological test scores (MMSE, MoCA, and AVLT) were worse in the patient group, short-and long-delay memory problems being more evident, suggesting that thalamic lesions result in a general decrease in cognitive function and memory. Both the dorsomedial and the anterior nuclei of the thalamus are involved in memory function [22] and Papez circuit disruption by thalamic damage also causes memory and emotional impairment [23], which may provide an anatomical explanation for the results that the memory deficit was more prominent and recovered little in patients with minor thalamic stroke in our study.…”

Section: Discussionsupporting

confidence: 54%

Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

Cui

et al. 2016

Neurosci. Bull.

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In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction (AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography (PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.

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Section: Discussionsupporting

confidence: 54%

Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

Cui

et al. 2016

Neurosci. Bull.

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“…Aggleton (2014) proposes that there are three parallel, yet distinct, “information streams” within the anterior thalamic nucleus (ATN) which integrate and work together to support episodic memory, while Nishio et al. (2014) demonstrated that the disruption of multiple thalamo‐cortical circuits can lead to prefrontal cortex dysfunction and memory deficits. This is supported by numerous studies which have highlighted the importance of thalamic‐PFC connectivity for memory and cognition (Cross, Brown, Aggleton, & Warburton, 2012; Funahashi, 2013; Gaffan, Murray, & Fabre‐Thorpe, 1993; Watanabe & Funahashi, 2012).…”

Section: Discussionmentioning

confidence: 99%

Thalamic functional connectivity and its association with behavioral performance in older age

et al. 2018

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IntroductionDespite the thalamus’ dense connectivity with both cortical and subcortical structures, few studies have specifically investigated how thalamic connectivity changes with age and how such changes are associated with behavior. This study investigated the effect of age on thalamo‐cortical and thalamo‐hippocampal functional connectivity (FC) and the association between thalamic FC and visual–spatial memory and reaction time (RT) performance in older adults.MethodsResting‐state functional magnetic resonance images were obtained from younger (n = 20) and older (n = 20) adults. A seed‐based approach was used to assess the FC between the thalamus and (1) sensory resting‐state networks; (2) the hippocampus. Participants also completed visual–spatial memory and RT tasks, from the Cambridge Neuropsychological Test Automated Battery (CANTAB).ResultsOlder adults exhibited a loss of specificity in the FC between sensory thalamic subregions and corresponding sensory cortex. Greater thalamo‐motor FC in older adults was associated with faster RTs. Furthermore, older adults exhibited greater thalamo‐hippocampal FC compared to younger adults, which was greatest for those with the poorest visual–spatial memory performance.ConclusionAlthough older adults exhibited poorer visual–spatial memory and slower reaction times compared to younger adults, “good” and “poorer” older performers exhibited different patterns of thalamo‐cortical and thalamo‐hippocampal FC. These results highlight the potential role of thalamic connectivity in supporting reaction times and memory in aging. Furthermore, these results highlight the importance of including the thalamus in studies of aging to fully understand how brain changes with age may be associated with behavior.

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“…Several thalamic structures within the diencephalon have been implicated, most commonly the mediodorsal nucleus (MD), the midline and intralaminar nuclei (ILN), the anterior thalamic nuclei (ATN), and the fibre pathways associated with these nuclei Dillingham et al, 2014;Mitchell and Chakraborty, 2013;Pergola and Suchan, 2013;Savage et al, 2012;. It is likely that human cases of amnesia involve damage to multiple thalamic sites and fibre tracts, some of which may affect many cognitive processes in addition to their influence on memory (Carlesimo et al, 2014;Carrera and Bogousslavsky, 2006;Cipolotti et al, 2008;Mennemeier et al, 1992;Nishio et al, 2014). Nonetheless, the bulk of human evidence for impaired recollection and episodic memory dysfunction (the hallmark of anterograde amnesia) most strongly implicates the ATN, the mammillary bodies (MB), and the mammillothalamic tract, a unique tract among limbic system neurocircuits because it provides a unidirectional link from the MB to ATN Carlesimo et al, 2011;Harding et al, 2000;Van der Werf et al, 2003;.…”

Section: Q3mentioning

confidence: 99%