Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

Wu, Wei; Cui, Linyang; Fu, Ying; Tian, Qianqian; Liu, Lei; Zhang, Xuan; Du, Nan; Chen, Ying; Qiu, Zhijun; Song, Yijun; Shi, Fu‐Dong; Xue, Rong

doi:10.1007/s12264-016-0036-7

Cited by 15 publications

(14 citation statements)

References 24 publications

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“…Neuropsychological examination and brain imaging studies have indicated that narcolepsy influences executive function and emotional and cognitive processing [39–43]. Executive function requires the control and coordination of several cognitive domains including working memory and reward sensitivity [44, 45]. Both working memory and reward sensitivity are functionally coordinated by prefrontal and mesial-frontal regions [1], which are abundantly linked to the hypocretin system [2, 46].…”

Section: Discussionmentioning

confidence: 99%

Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy

Xiao

Zhao

et al. 2018

Neurosci. Bull.

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The present study was aimed to evaluate resting-state functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls. Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched healthy controls. MRI data were first analyzed by group independent component analysis, then a graph theoretical method was applied to evaluate the topological properties in the whole brain. Small-world network parameters and nodal topological properties were measured. Altered topological properties in brain areas between groups were selected as region-of-interest seeds, then the functional connectivity among these seeds was compared between groups. Partial correlation analysis was performed to evaluate the relationship between the severity of sleepiness and functional connectivity or topological properties in the narcolepsy patients. Twenty-one independent components out of 48 were obtained. Compared with healthy controls, the narcolepsy patients exhibited significantly decreased functional connectivity within the executive and salience networks, along with increased functional connectivity in the bilateral frontal lobes within the executive network. There were no differences in small-world network properties between patients and controls. The altered brain areas in nodal topological properties between groups were mainly in the inferior frontal cortex, basal ganglia, anterior cingulate, sensory cortex, supplementary motor cortex, and visual cortex. In the partial correlation analysis, nodal topological properties in the putamen, anterior cingulate, and sensory cortex as well as functional connectivity between these regions were correlated with the severity of sleepiness (sleep latency, REM sleep latency, and Epworth sleepiness score) among narcolepsy patients. Altered connectivity within the executive and salience networks was found in narcolepsy patients. Functional connection changes between the left frontal cortex and left caudate nucleus may be one of the parameters describing the severity of narcolepsy. Changes in the nodal topological properties in the left putamen and left posterior cingulate, changes in functional connectivity between the left supplementary motor area and right occipital as well as in functional connectivity between the left anterior cingulate gyrus and bilateral postcentral gyrus can be considered as a specific indicator for evaluating the severity of narcolepsy. Electronic supplementary material The online version of this article (10.1007/s12264-018-0307-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy

Xiao

Zhao

et al. 2018

Neurosci. Bull.

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“…The thalamo-frontal circuit [16][17][18] as well as the cortico-thalamo-basal ganglia-cortical circuit [8,16] are crucial in the recovery from DOCs, and atrophy of the thalamus has been found to be proportional to the severity of DOCs [8]. In addition to its function in DOCs, some studies have also shown that the thalamus is important in many aspects of forebrain function through various projection patterns, such as those that control alertness, attention, and awareness, and those that regulate sleep-wake rhythms [19,20].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness

Chen

Xie

et al. 2018

Neurosci. Bull.

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A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.

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“…8 An increase in sleep duration or need is particularly often found in patients with (bilateral) lesions of the paramedian thalamus. 6,9 Symptoms such as fatigue, insomnia, and EDS are common after stroke. 10,11 Restless legs syndrome (RLS), in contrast, does not seem to be more prevalent after stroke than in the general population.…”

Section: Subjective Assessmentsmentioning

confidence: 99%

Measuring Sleep, Wakefulness, and Circadian Functions in Neurologic Disorders

Schmidt

Dekkers

Baillieul

et al. 2021

Sleep Medicine Clinics

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Neurologic disorders impact the ability of the brain to generate sleep, wake, and circadian functions. Preexisting or de novo sleep-wake-circadian pathologies are generally underdiagnosed in neurologic patients despite their major impact on onset, evolution, and outcome of neurologic disorders. Neurologic disorders are frequently accompanied by sleep-wake EEG changes. Extensive brain damage can lead to the absence of measurable differentiation between sleep and wakefulness (status dissociatus). New technologies will facilitate early detection and (long-term) monitoring of neurologic patients and the optimization of their clinical management.

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Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

Cited by 15 publications

References 24 publications

Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy

Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy

Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness

Measuring Sleep, Wakefulness, and Circadian Functions in Neurologic Disorders

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