Multiple Spreading Epidermolytic Acanthomas of the Genital and Perigenital Skin

Réguiai, Z.; Cribier, B.; Derancourt, Christian; Perceau, G.; Bernard, Philippe

doi:10.1159/000086447

Cited by 17 publications

(12 citation statements)

References 32 publications

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“…PCR and immunohistochemical staining (Ki‐67, p16 and p21) could not demonstrate an association with HPV infection in our cases. In a literature review, we found that six other patients had also been tested for HPV, but immunohistochemical and molecular studies both failed to detect viral genome …”

Section: Discussionmentioning

confidence: 99%

Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

Lee

2017

Int J Dermatology

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The genital area was the most common location for multiple EAs, which was commonly misdiagnosed clinically as condyloma. Patients presenting with uniformly small-sized, skin-colored to whitish, smooth papular lesions in the genitalia should be carefully evaluated. The specific pathological features of epidermolytic hyperkeratosis are diagnostic, and the lesions can be observed without aggressive treatment after confirmed diagnosis.

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Section: Discussionmentioning

confidence: 99%

Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

Lee

2017

Int J Dermatology

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“…The morphological appearance and the anogenital location of EA frequently lead to confusion with a number of conditions, including genital warts, seborrhoeic keratosis, molluscum contagiosum, bowenoid papulosis, and Darier disease. EA may also mimic HPV infection histologically, with overlapping features of hyperkeratosis, acanthosis, and papillomatosis .…”

Section: Discussionmentioning

confidence: 99%

Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment

Tan

Tey

2013

Dermatol Ther

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Epidermolytic acanthoma is an uncommon benign tumor with a predilection for the anogenital region, that is characterized histologically by epidermolytic hyperkeratosis. Most reported cases are asymptomatic while some are pruritic. Treatment of this condition is challenging and not well studied. We report a 55-year-old man with pruritic anogenital epidermolytic acanthomas that persisted despite various topical and ablative therapies, and whose pruritus was not relieved with emollients and antihistamines. He was given 0.1% tacrolimus ointment twice daily and experienced a marked improvement in his pruritus within 2 weeks. At 1 month, there was marked improvement in itch score from 8 to 3.5 (maximum of 10), itch frequency from 20 times a day to once every 4 days, sleep score from 5 to 1 (maximum of 5), and Dermatology Life Quality Index score from 15 to 5 (maximum of 30). Apart from a transient burning sensation, no other adverse effects were noted. To our knowledge, this is the first report of the effective use of a topical calcineurin inhibitor in relieving the intractable itch associated with epidermolytic acanthoma.

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“…EHK and AD may both be seen histologically in multiple, papular genital lesions 25,26 . Both may also be seen adjacent to atypical nevi 21 .…”

Section: Discussionmentioning

confidence: 99%

Clear (pale) cell acanthosis as an incidental finding

Ko¹,

Subtil²

2009

J Cutan Pathol

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Different patterns of epidermal change, including epidermolytic hyperkeratosis and acantholytic dyskeratosis, may represent the predominant histopathologic finding in several localized and generalized processes. Occasionally, minute foci of these reaction patterns are identified as an incidental finding in a biopsy taken because of the presence of some other lesion. Clear (pale) cell acanthosis may occur as the main histologic alteration in clear (pale) cell acanthoma or incidentally, such as may be seen within a seborrheic keratosis. Two cases of incidental minute foci of clear (pale) cell acanthosis are described and put into the broader context of other epidermal histologic reaction patterns.

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Multiple Spreading Epidermolytic Acanthomas of the Genital and Perigenital Skin

Cited by 17 publications

References 32 publications

Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment

Clear (pale) cell acanthosis as an incidental finding

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