Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

Lee, Leon Tsung-Ju; Wu, Yu‐Hung

doi:10.1111/ijd.13818

Cited by 13 publications

(48 citation statements)

References 23 publications

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“…[73][74][75] The lesions are skin-colored or whitish papules with a smooth or verruciform surface, frequently confused with condyloma acuminatum clinically. 74,76 Multiple reports have confirmed the absence of HPV in epidermolytic acanthomas, 73,76,77 although 1 reported case of scrotal epidermolytic acanthoma tested positive for HPV 16 when using a highly sensitive HPV DNA chip. 78 It is possible that HPV was an incidental finding, rather than a pathogenic agent, in this isolated case.…”

Section: Verruca Vulgarismentioning

confidence: 99%

“…The lesion is acanthotic and hyperkeratotic with variable degree of papillomatosis and/ or invagination (Figure 8, A). 76,79 The histopathologic pattern is that of epidermolytic hyperkeratosis (EHK), in which the keratinocytes in the granular and spinous layers display cytoplasmic vacuolation, reticular degeneration, coarse keratohyalin granules, and perinuclear eosinophilic inclusions (Figure 8, B). 73,76,79 Despite superficial resemblance to koilocytosis, these unique characteristics of EHK effectively exclude condyloma acuminatum and VV.…”

Section: Verruca Vulgarismentioning

confidence: 99%

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Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region

Chan

2018

Archives of Pathology &Amp; Laboratory Medicine

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- Correct diagnosis of condyloma acuminatum and condyloma-like lesions has important clinical implication and entails familiarization with their clinical presentations and histopathologic features. Contrary to historical belief, giant condyloma acuminatum and verrucous carcinoma should be considered distinct entities based on different pathogenetic pathways. Ancillary tools available for identifying and genotyping human papillomavirus can aid in diagnosis when histopathologic findings are inconclusive. Recognition of relatively rare entities such as bowenoid papulosis, epidermolytic acanthoma, and verruciform xanthoma would avoid overdiagnosis and unnecessary, overaggressive treatment.

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Section: Verruca Vulgarismentioning

confidence: 99%

Section: Verruca Vulgarismentioning

confidence: 99%

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region

Chan

2018

Archives of Pathology &Amp; Laboratory Medicine

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“…However, human papillomavirus (HPV) typing has been consistently negative, except a single case 7 which showed HPV 16 positivity. 8,9 HPV may be commonly found in normal genital skin, perhaps explaining that finding. Mutations affecting keratin 1, 2 or 10 have been postulated to have a role in EA because EHK-associated inherited dermatoses such as epidermolytic ichthyosis are caused by mutations in these genes and show an identical histological pattern.…”

Section: Introductionmentioning

confidence: 93%

“…When occurring on the genitalia, especially in the setting of multiple lesions, EA may mislead both clinicians and pathologists into a diagnosis of condyloma accuminatum, with its accompanying potential psychological burden (Figure ). However, human papillomavirus (HPV) typing has been consistently negative, except a single case which showed HPV 16 positivity . HPV may be commonly found in normal genital skin, perhaps explaining that finding.…”

Section: Introductionmentioning

confidence: 99%

Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases

et al. 2019

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BACKGROUND Epidermolytic acanthoma (EA) is a rare, benign acquired cutaneous keratosis displaying epidermolytic hyperkeratosis in more than 50% of its surface. Because of the sparsity of comprehensive studies, little is known on the patient demographics and clinical characteristics of this uncommon entity. We wish to comprehensively characterize the clinical and demographic features of EA and to differentiate it from its mimickers. METHODS We carried out a retrospective review of 131 cases of EA, recorded clinical and histopathologic features and performed linear regression of yearly incidence rates to assess for possible under‐reporting of this entity. RESULTS EA affected both genders equally. We found 9.08 cases per 100 000 biopsy specimens per year and linear regression analysis showed significantly decreasing incidence rates. Analysis of the anatomical site distribution of EA lesions showed a more frequent genital location in men (39.1% of cases in men, as compared to 11.3% for women). Contrary to previous studies, lesions were most frequently single (91.7%) and the mean age of presentation was 57.8 years. CONCLUSION The presented largest case series to‐date indicates that EA is probably an underdiagnosed entity and establishes the demographic and clinical features of EA.

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“…EA occurs anywhere on the body, but lesions that arise on the genitalia, which are interestingly more common in men than women, can be especially distressing as a result of frequent misdiagnosis as condyloma accuminatum . Nevertheless, human papillomavirus typing is usually negative in EA …”

Section: Introductionmentioning

confidence: 99%

Mutations in KRT10 in epidermolytic acanthoma

et al. 2020

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Background: Epidermolytic acanthoma (EA) is a rare acquired lesion demonstrating a characteristic histopathological pattern of epidermal degeneration referred to as epidermolytic hyperkeratosis (EHK). On histopathological analysis, EA appears nearly identical to inherited EHK-associated dermatoses such as epidermolytic ichthyosis and ichthyosis bullosa of Siemens. While it has been speculated that EA is caused by mutations in KRT10, KRT1, or KRT2 found in these inherited dermatoses, none have yet been identified. Herein, we aim to identify the contributions of keratin mutations to EA.Methods: Using genomic DNA extracted from paraffin-embedded samples from departmental archives, we evaluated a discovery cohort using whole-exome sequencing (WES) and assessed remaining samples using Sanger sequencing screening and restriction fragment length polymorphism (RFLP) analysis. Results: DNA from 16/20 cases in our sample was of sufficient quality for polymerase chain reaction amplification. WES of genomic DNA from lesional tissue revealed KRT10 c.466C > T, p.Arg156Cys mutations in 2/3 samples submitted for examination. RFLP analysis of these samples as well as eight additional samples confirmed the mutations identified via WES and identified four additional cases with Arg156 mutations. In sum, 6/11 screened cases showed hotspot mutation in KRT10. Conclusions: Hotspot mutations in the Arg156 position of KRT10, known to cause epidermolytic ichthyosis, also underlie EA. K E Y W O R D S epidermolytic acanthoma, keratin 10, KRT10, mutations, whole-exome sequencing

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Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases

Cited by 13 publications

References 23 publications

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region

Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases

Mutations in KRT10 in epidermolytic acanthoma

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