Multiple sites of action of ( +)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine (( +)-3PPP) in blood vessels

Massamiri, Tania; Duckles, Sue Piper

doi:10.1016/0014-2999(90)94193-2

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Finally, it is capable of potentializing or inhibiting the NA-induced contraction on the postsynaptic side [45][46][47][48]. Thus, (+)-3-PPP blocks the release of noradrenaline (NA) through activation of the D 2 receptors of dopamine, and prevents its reuptake by inhibiting the presynaptic transporter -the latter being the usual target of cocaine.…”

Section: M P L I C a T I O N O F S I G M A R E C E P T O R S I N T mentioning

confidence: 99%

“…Thus, (+)-3-PPP blocks the release of noradrenaline (NA) through activation of the D 2 receptors of dopamine, and prevents its reuptake by inhibiting the presynaptic transporter -the latter being the usual target of cocaine. Finally, it is capable of potentializing or inhibiting the NA-induced contraction on the postsynaptic side [45][46][47][48]. Suppression of endothelium does not seem to influence these complex effects, at least in rats [48].…”

Section: M P L I C a T I O N O F S I G M A R E C E P T O R S I N T mentioning

confidence: 99%

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Sigma receptors: from discovery to highlights of their implications in the cardiovascular system

Monassier¹,

Bousquet²

2002

Fundamemntal Clinical Pharma

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Sigma receptors are the targets of many ligands, of which some (the haloperidol for instance) are psychoactive, and of substances known to have antiarrhythmic effects (amiodarone and clofilium). They are involved in a variety of cardiovascular functions, such as the regulation of cardiac contractility and rhythm and the regulation of coronary and peripheral arterial vasomotricity. This short review will focus on some aspects regarding the ligands, the binding sites, the intracellular coupling and the cardiovascular functions of these enigmatic receptors.

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Section: M P L I C a T I O N O F S I G M A R E C E P T O R S I N T mentioning

confidence: 99%

Section: M P L I C a T I O N O F S I G M A R E C E P T O R S I N T mentioning

confidence: 99%

Sigma receptors: from discovery to highlights of their implications in the cardiovascular system

Monassier¹,

Bousquet²

2002

Fundamemntal Clinical Pharma

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Dextromethorphan Attenuated Inflammation and Combined Opioid Use in Humans Undergoing Methadone Maintenance Treatment

Lee

Tao

Chang

et al. 2012

J Neuroimmune Pharmacol

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Recent studies show that proinflammatory cytokines might be related to the development of opioid dependence (physiological, psychological, or both). In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence. All participants (107 heroin-dependent patients and 84 nondependent healthy controls) were recruited from National Cheng Kung University Hospital. Their plasma cytokine levels were measured to evaluate the effect of add-on dextromethorphan. Plasma TNF-α and IL-8 levels were significantly higher in long-term heroin-dependent patients than in healthy controls (p < 0.001). Chronic heroin-use-induced TNF-α and IL-8 levels were significantly (p < 0.05) attenuated in patients treated for 12 weeks with add-on dextromethorphan. Moreover, both tolerance to methadone and the combined use of opioids were significantly (p < 0.05) attenuated in patients taking dextromethorphan. We conclude that dextromethorphan might be a feasible adjuvant therapeutic for attenuating inflammation and inhibiting methadone tolerance and combined opioid use in heroin-dependent patients.

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Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors

Hariton¹

1994

European Journal of Pharmacology

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Multiple sites of action of ( +)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine (( +)-3PPP) in blood vessels

Cited by 7 publications

References 15 publications

Sigma receptors: from discovery to highlights of their implications in the cardiovascular system

Sigma receptors: from discovery to highlights of their implications in the cardiovascular system

Dextromethorphan Attenuated Inflammation and Combined Opioid Use in Humans Undergoing Methadone Maintenance Treatment

Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors

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