Multiple Serous Retinal Detachments and Subretinal Deposits as the Presenting Signs of Metastatic Melanoma

Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

“…To our knowledge, 23 cases of PVM, albeit under different designations, have been reported in the literature (Table 1). 14,20,33,35,69,93,120,122,136,147,148,200,214,265,271,301 All but two carried a known diagnosis of malignancy. Until recently, all known cases were associated with either choroidal or cutaneous melanomas, leading many authors to speculate these may be atypical variants of MAR; however, three recent reports demonstrated similar findings in patients with non-melanoma malignancies.…”

“…The average age of onset is 59 years (range, 33e80 years), with an equal sex distribution. 14,20,33,35,69,93,120,122,136,147,148,200,214,265,271,301 The most common presentation is nyctalopia, although some patients experienced blurry vision, metamorphopsia, shimmering photopsias, glare, and halos. Clinically, PVM may more closely resemble other vitelliform retinopathies, such as acute exudative polymorphous vitelliform maculopathy, or the multifocal variant of Best's disease, than MAR or CAR.…”

Paraneoplastic vitelliform retinopathy associated with metastatic choroidal melanoma

“…[1][2][3][4][5] In four cases, both antiretinal antibodies and ERG abnormalities were found. 1,[3][4][5] In one case, antiretinal antibodies were detected; however, ERG was not performed.…”

“…2 This style of PP has a wide disc-shaped top/cap that sits level on the punctal opening to prevent plug migration into the canaliculus. Conjunctival irritation caused by this exposed part of PP may warrant plug removal in a small number of treated patients (1.5%).…”

“…Only three cases associated with choroidal melanoma, [1][2][3] five cases with cutaneous melanoma, [3][4][5] and one case with metastatic melanoma of an unknown primary site 2 have been reported yet. Here we describe a patient with metastatic choroidal melanoma and paraneoplastic vitelliform fundus findings.…”