Multiple Sclerosis: Effects of Cognitive Rehabilitation on Structural and Functional MR Imaging Measures—An Explorative Study

Filippi, Massimo; Riccitelli, Gianna Carla; Mattioli, Flavia; Capra, Ruggero; Stampatori, Chiara; Pagani, Elisabetta; Valsasina, Paola; Copetti, Massimiliano; Falini, Andrea; Comı, Gıancarlo; Rocca, Maria A.

doi:10.1148/radiol.11111299

Cited by 185 publications

(194 citation statements)

References 46 publications

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“…Interestingly enough, changes in RS FC connectivity of cognitive-related networks helped to explain the persistence of the effects of cognitive rehabilitation in the patients several months after treatment termination and the patients improvement on depression and quality of life scales, suggesting that cognitive rehabilitation exerts a positive effect that is not limited to the trained function but extends to several additional domains. 60 Notably, the previous study 59 found no structural changes in the GM and NAWM following cognitive rehabilitation. Such a negative finding might reflect an impairment of structural plasticity in these patients, which is likely to be caused by the MS pathological process.…”

Section: Msmentioning

confidence: 86%

Functional MRI in investigating cognitive impairment in multiple sclerosis

Rocca

Meo²,

Filippi

2016

Acta Neurol Scand

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Section: Msmentioning

confidence: 86%

Functional MRI in investigating cognitive impairment in multiple sclerosis

Rocca

Meo²,

Filippi

2016

Acta Neurol Scand

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“…[25][26][27][28] This may be explained at least in part by several factors: lesions in "eloquent" brain areas such as the optic nerves are more likely to be clinically expressed than lesions in less eloquent pathways; the degree of matrix and axonal destruction may vary; and the potential exists for rapid symptom recovery. [29][30][31][32][33][34][35][36][37][38] Even patients with progressive forms of MS, particularly those with Gd+ lesions indicating a subclinical relapse, may respond clinically to disease-modifying therapies (DMTs). For example, in a post hoc analysis of the Olympus trial of rituximab in PPMS, patients with Gd+ lesions had a significantly better response to treatment than those without Gd+ lesions.…”

Section: Background Historical Evolution Of Ms Diagnostic Criteriamentioning

confidence: 99%

Use of Magnetic Resonance Imaging as Well as Clinical Disease Activity in the Clinical Classification of Multiple Sclerosis and Assessment of Its Course

Cook¹,

Dhib‐Jalbut²,

Dowling³

et al. 2012

International Journal of MS Care

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It has recently been suggested that the Lublin-Reingold clinical classification of multiple sclerosis (MS) be modified to include the use of magnetic resonance imaging (MRI). An international consensus conference sponsored by the Consortium of Multiple Sclerosis Centers (CMSC) was held from March 5to 7, 2010, to review the available evidence on the need for such modification of the Lublin-Reingold criteria and whether the addition of MRI or other biomarkers might lead to a better understanding of MS pathophysiology and disease course over time. The conference participants concluded that evidence of new MRI gadolinium-enhancing (Gd+) T1-weighted lesions and unequivocally new or enlarging T2-weighted lesions (subclinical activity, subclinical relapses) should be added to the clinical classification of MS in distinguishing relapsing inflammatory from progressive forms of the disease. The consensus was that these changes to the classification system would provide more rigorous definitions and categorization of MS course, leading to better insights as to the evolution and treatment of MS. Int J MS Care. 2012;14:105-114. It was recently suggested by Lincoln et al. 1 that the Lublin-Reingold clinical classification of multiple sclerosis (MS) 2 for the assessment of MS phenotypes and patient evolution over time be modified to include magnetic resonance imaging (MRI). It was recommended that the classification incorporate the "conventional," generally available MRI techniques of gadolinium (Gd) T1-weighted sequences and dual-echo and fluid-attenuated inversion recovery (T2-weighted and FLAIR) images ( course over time and, in turn, more informed clinical trials and a better understanding of appropriate therapies.Prior to the meeting, a survey of members of the CMSC was conducted on the need to modify the Lublin-Reingold classification. Over a 1-week period, 141 responses were received, representing 16% of the CMSC members polled. The results were as follows: A total of 70% of respondents indicated that the LublinReingold classification did not sufficiently distinguish the different forms of MS; 87% felt that the LublinReingold classification did not sufficiently distinguish MS disease activity even within a given category of the disease; and 84% indicated that it would be useful to include certain subclinical indices of disease activity in the clinical classification, such as MRI gadoliniumother MRI modalities that are not currently widely available and other validated biomarkers might be added to the classification in the future.In response to the publication of Lincoln et al., 1 the Consortium of Multiple Sclerosis Centers (CMSC) sponsored an international consensus conference, which was held in Short Hills, New Jersey, from March 5 to 7, 2010. Participating in the conference were 28 invited MS experts from North and South America and Europe who were well versed in clinical trials, the management of MS, biostatistics, neuropathology, neuroimaging, and neuroimmunology. The goal of the meeting was to review the available...

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“…Historically, most of the intervention implemented for use with MS patients involved learning and memory-based interventions, 15 but recently the focus has moved to other domains such as executive function and attention 21,23,30,31,32,47,48,49 , since these are the cognitive functions that have been shown to be most affected by MS. Interventions based on these functions appear to lead to more consistent results.…”

Section: Introductionmentioning

confidence: 99%