Functional MRI in investigating cognitive impairment in multiple sclerosis

Rocca, Maria A.; Meo, Ermelinda De; Filippi, Massimo

doi:10.1111/ane.12654

Cited by 27 publications

(16 citation statements)

References 62 publications

(38 reference statements)

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“…57 However, the adult MS literature indicates that this apparent plasticity is lost over time and that later functional reorganization may not be beneficial. 53,57,58…”

Section: Structural and Functional Mri Analysesmentioning

confidence: 99%

Multiple Sclerosis in Children: Current and Emerging Concepts

et al. 2020

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Multiple sclerosis is being increasingly recognized and diagnosed in children. In the past several years, advances have been made in diagnosing multiple sclerosis in children, identifying new genetic and environmental risk factors, delineating underlying immunobiology, characterizing imaging findings, and implementing new treatment strategies. In this review, we discuss these advances. Future research into the determinants of multiple sclerosis in children and into new treatment options will be aided by continued international collaboration.

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“…57 However, the adult MS literature indicates that this apparent plasticity is lost over time and that later functional reorganization may not be beneficial. 53,57,58…”

Section: Structural and Functional Mri Analysesmentioning

confidence: 99%

Multiple Sclerosis in Children: Current and Emerging Concepts

et al. 2020

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“…Whether this cortical reorganization in MS is adaptive or maladaptive mechanism remains unclear. It is thought that it is a rather complex interaction among tissue damage, tissue repair, and cortical reorganization . A limitation of our study is the relatively small number of recruited subjects in the MS group, which prevented us from subdividing the patients into cognitively, preserved and cognitively impaired subgroups.…”

Section: Discussionmentioning

confidence: 99%

“…It is thought that it is a rather complex interaction among tissue damage, tissue repair, and cortical reorganization. 26 A limitation of our study is the relatively small number of recruited subjects in the MS group, which prevented us from subdividing the patients into cognitively, preserved and cognitively impaired subgroups. The use of PVSAT fMRI paradigm in combination with PASAT score may be discussed as another shortcoming of our study.…”

Section: Correlation Between Bold Activations During Pvsat and Pasamentioning

confidence: 99%

Translational validity of PASAT and the effect of fatigue and mood in patients with relapsing remitting MS: A functional MRI study

Iancheva

Trenova

Terziyski

et al. 2018

Evaluation Clinical Practice

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“…23 The investigation of cognition in MS patients with FMRI has the potential to provide useful data about brain connectivity and cortical reorganization. 24 The methodology in investigating cognition with FMRI techniques includes task dependent design with an on/off paradigm to localize brain activity. Three main areas have been investigated: working memory, attention and executive functions using several paradigms.…”

Section: Functional Mri In Multiple Sclerosismentioning

confidence: 99%

“…In result information about resting state networks and their possible functional reorganization is acquired. 23,24…”

Section: Functional Mri In Multiple Sclerosismentioning

confidence: 99%

Structural and Functional MRI Techniques in Multiple Sclerosis Related Cognitive Dysfunction

Iancheva¹,

Trenova²,

Mantarova³

et al. 2018

Folia Medica

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Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system that is prevalent in young adults and therefore with significant social impact. Cognitive impairment occurs in 40% to 70% of patients with MS and has a weak correlation with disease duration. Neuropsycho-logical assessment is a standard method in the detection of cognitive dysfunction. However, in order to understand the etiology and evolution of cognitive dysfunction, several elaborate magnetic resonance techniques have been developed. Their aim is to measure structural changes in the CNS that are considered main substrates in cognitive function such as whole brain and gray matter atrophy, cortical lesions and changes in subcortical gray matter. Evidence shows that the clinical manifestations of multiple sclerosis are complex interactions between tissue damage, tissue repair and cortical reorganization. In order to study this heterogeneity, structural magnetic resonance analysis of brain morphology and functional magnetic resonance imaging are essential. This review summarizes current techniques in structural MRI and the value of functional MRI in understanding the link between cognitive deficit and cortical activation and reorganization.

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Functional MRI in investigating cognitive impairment in multiple sclerosis

Cited by 27 publications

References 62 publications

Multiple Sclerosis in Children: Current and Emerging Concepts

Multiple Sclerosis in Children: Current and Emerging Concepts

Translational validity of PASAT and the effect of fatigue and mood in patients with relapsing remitting MS: A functional MRI study

Structural and Functional MRI Techniques in Multiple Sclerosis Related Cognitive Dysfunction

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