Translational validity of PASAT and the effect of fatigue and mood in patients with relapsing remitting MS: A functional MRI study

Iancheva, Dessislava; Trenova, Anastasiya G.; Terziyski, Kiril; Kandilarova, Sevdalina; Mantarova, Stefka

doi:10.1111/jep.12913

Cited by 8 publications

(4 citation statements)

References 28 publications

(73 reference statements)

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“…During the “repeat” condition, the participants were instructed to silently repeat once each presented number. There were four blocks of each type, alternating between add and repeat followed always by a 21 s “off” block representing a centrally located fixation cross, during which the participants were instructed to look at the cross without thinking of anything in particular (12).…”

Section: Methodsmentioning

confidence: 99%

Functional Magnetic Resonance Imaging Correlations Between Fatigue and Cognitive Performance in Patients With Relapsing Remitting Multiple Sclerosis

et al. 2019

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The correlation between fatigue and cognitive performance in multiple sclerosis (MS) is well reported, but the intimate mechanisms of the fatigue impact on cognition are not fully defined yet. The aim of this study is to investigate blood oxygen level–dependent (BOLD) activations in relapsing remitting MS (RRMS) patients with and without cognitive dysfunction and the impact of fatigue on cortical activations. Forty-two patients with RRMS were enrolled in the study. Cognitive functioning was assessed by the Symbol Digit Modalities Test (SDMT) and Paced Serial Addition Test (PASAT). A cutoff point of a total score of 55 on the SDMT was used to divide the patients into two groups: cognitively impaired (CI), SDMT score equal to or below 55 points, and cognitively preserved (CP), SMDT score above 55 points. Fatigue was assessed by the Modified Fatigue Impact Scale (MFIS). Participants were assessed with the Beck Depression Inventory (BDI) prior to inclusion in order to exclude major depressive episode. Functional Magnetic Resonance Imaging (fMRI) scanning was performed on a 3T MRI. The PVSAT (Paced Visual Serial Addition Test) paradigm was applied as a cognitive task. All functional data were analyzed with SPM12 and statistical analysis with SPSS 19.0. No statistically significant differences between CI and CP patients were found (p=0.953, p=0.322) in the MFIS and BDI score. Performance on the PASAT in CI patients was 34.07±13.721, for CP patients 46.42±11.453, and the SDMT performance in the CI patient group was 42.40±9.179, in the CP group 57.83±2.552. Between-group analysis revealed increased activations in left Brodmann area (BA) 40 in CP patients with several clusters located in the left supramarginal gyrus. Regression analysis showed increased BOLD signal in left BA 40, right BA 40, and left BA 6, associated with a higher score on MFIS. Stronger BOLD signal in left BA 31 was associated with a lower score on MFIS. Significance level was set to p<0.05, FWE (family-wise error) corrected. The differences in BOLD activations suggest the presence of cortical reorganization in our CP patients. The impact of fatigue on cortical activation during a cognitive task is demonstrated by inconformity of activated areas depending on the MFIS score. Our results suggest that activation in BA 40 may represent a mechanism for diminishing fatigue impact on cognitive functioning in CP patients.

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Section: Methodsmentioning

confidence: 99%

Functional Magnetic Resonance Imaging Correlations Between Fatigue and Cognitive Performance in Patients With Relapsing Remitting Multiple Sclerosis

et al. 2019

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“…Functionally, resting-state functional MRI (rs-fMRI) has attracted increasing attention to be used to explore intrinsic brain activity and connectivity (Fox and Greicius, 2010; Iancheva et al, 2018; Kandilarova et al, 2018; Zhao et al, 2018). Several studies of MSA-p type found the disruption of the striatal-thalamo-cortical (STC) network, default mode network (DMN), visual associated cortices (Wang et al, 2017), as well as cerebello-thalamo-cortical (CTC) network (Yao et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Spatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study

et al. 2019

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Multiple system atrophy (MSA) is a progressive neurodegenerative disease. However, little is known about the regional cerebral blood flow (rCBF) and functional connectivity changes in the disease. In this study, the magnetic resonance imaging (MRI) data including 24MSA-c-type patients and 20 healthy controls were collected by using voxel wise arterial spin labeling (ASL) perfusion analysis, several regions of the altered rCBF were identified in the MSA c-type patients. And then, the changes of the functional connectivities of identified rCBF regions were analyzed by using functional MRI (fMRI). Finally, rCBF value of cerebellum was extracted to differentiate the MSA c-type patients and controls. Compared with the controls, the MSA c-type patients showed distinct disruption of rCBF in the cerebellum. The disconnection of the identified cerebellar regions was revealed in several regions in the MSAc-type patients, including right middle frontal gyrus (MFG), right precuneus, left superior temporal gyrus (STG), right lingual gyrus, left postcentral gyrus (PoCG), right cerebellum 7b, right cerebellum 8, and left cerebellum 4,5. These regions were involved in the default mode network (DMN), sensorimotor network, visual associated cortices, and cerebellum. Using the rCBF value of vermis as biomarker, the two groups can be differentiated and reached a sensitivity of 95.8% and specificity of 100%. This is the first study to demonstrate the MSA-specific rCBF abnormalities using the ASL method, which are closely associated with several functional networks on resting state fMRI. The rCBF of vermis might be used as the potential imaging biomarker for the early diagnosis of MSA c-type.

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“…Neuroscience operates validation procedures on an essentially similar basis, in search for post hoc correlations with the associated psychological scores and several papers in this Special Section exemplify an attempt to methodologically integrate the data from neuroscience with those from clinical psychological and neuropsychiatric evaluation. Here, the works by Kandilarova and colleagues, Haralanov, Terziivanova, and associates, Iancheva and co‐workers, and Gaberova, Yordanova, and colleagues are noteworthy and should be read alongside the contribution by Matanova et al who discuss the importance of brain‐based therapeutic strategies, although the identification of various inconsistencies calls for further investigations within the frameworks outlined.…”

Section: Translating the Findings Of Neuroscience Into Clinical Medicmentioning

confidence: 99%

Editorial introduction: The implications of translational neuroscience for clinical practice and its evaluation

Miles¹

2018

Evaluation Clinical Practice

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Translational validity of PASAT and the effect of fatigue and mood in patients with relapsing remitting MS: A functional MRI study

Cited by 8 publications

References 28 publications

Functional Magnetic Resonance Imaging Correlations Between Fatigue and Cognitive Performance in Patients With Relapsing Remitting Multiple Sclerosis

Functional Magnetic Resonance Imaging Correlations Between Fatigue and Cognitive Performance in Patients With Relapsing Remitting Multiple Sclerosis

Spatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study

Editorial introduction: The implications of translational neuroscience for clinical practice and its evaluation

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