Multiple sclerosis: an associated single-nucleotide polymorphism study on Egyptian population

Abstract

Multiple Sclerosis (MS) is an autoimmune disease that severely impacts the central nervous system. Thanks to the evolutionary genetic information studied and published, researches have started to study MS from a genetic perspective. This paper provides a study of six single-nucleotide polymorphisms (SNPs)-MIR137HG (rs1625579), GAS5 (rs2067079), MIR3142HG (rs57095329), MIR146A (rs2910164), MIR155HG (rs767649) and IRAK1 (rs3027898)-and demonstrates their association with MS. This study was applied over an Egyptian dataset of 38 MS patients and 35 controls. Hence, different models were applied, Dominant, Recessive and Genotypic models along with Fisher's Exact method, Basic case-control analysis and Logistic regression analysis. This paper shows that the SNPs rs1625579, rs57095329, rs767649 and rs3027898 are associated with MS (p value < 0.05) according to all tested models except for Recessive model, that has add-in the relevance of rs1625579, rs57095329, rs2910164 and rs767649 with MS disease.

Assessment Of Health Related Quality Of Life Among Patients With Multiple Sclerosis At Minia University Hospital

“…Variables Table (1) clears that, 55 % of study sample their age ranged from 20-30 years, 3.3 % their age more than 50 years old, 73.3% of study sample are females but 26.7% are male. Regarding their education 53.3% of them are university or high education, 10% are able to read and write, but 11.7% are illiterate.…”

“…This sheath manages the transmission space of electrons across neurons, so if this sheath got damaged, or destroyed, the nerve impulses get slower or do not transmit at all, leading to disrupted communication between the brain and other parts of the body. (Abd El Hamid et al, 2020) The cause of multiple sclerosis is unknown. It is consider an autoimmune disease which the body's immune system attacks the central nervous system.…”

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“…This step is commonly applied automatically using genotyping tools such as PLINK [55].Patients datasets primarily includes the MS type (the data point label), the patients' treatment protocols, personal information, and some RNA data might be included. A snippet of a simple MS patients' dataset is demonstrated in figure 4 the last five columns denote the SNPs to be studied [56].…”

“…Procedures of MS detection by classifying genetic data using SNPs snippet of MS patients' raw dataset[56] …”