Multiple sclerosis among immigrants in Greater London.

Dean, Geoffrey; McLoughlin, H; Brady, R; Adelstein, A M; Tallett-Williams, J

doi:10.1136/bmj.1.6014.861

Cited by 117 publications

(63 citation statements)

References 3 publications

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“…Compared to other ethnic groups residing at the same latitudes, people of northern European ancestry are at higher risk for MS (Dean et al, 1976;Pugliatti et al, 2002;Alter et al, 2006;Smestad et al, 2008). This increased susceptibility might be due to genetic differences between ethnic groups.…”

Section: Geography and Ethnicitymentioning

confidence: 98%

Multiple sclerosis genetics

Cree

2014

Handbook of Clinical Neurology

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Section: Geography and Ethnicitymentioning

confidence: 98%

Multiple sclerosis genetics

Cree

2014

Handbook of Clinical Neurology

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“…1 Epidemiological analysis of twins, 2,3 half-sibs 4 and adoptees 5 confirm the involvement of genetic factors while the role of environmental agents is demonstrated by the results of migration studies. 6 In Australia, studies of the prevalence of multiple sclerosis have been particularly influential showing a latitudinal relationship similar to that seen in the Northern Hemisphere with lower rates in northern regions closer to the equator (11/100 000) than in the south (74/ 100 000). 7,8 However, overall, these prevalence rates are lower than those seen in Northern Europe, even though the majority of the Australian population originates from Northern Europe, suggesting that, despite expressing the same susceptibility genes, Australians may be at relatively reduced risk of multiple sclerosis through differential exposure to the causative environmental risk factors.…”

Section: Introductionmentioning

confidence: 93%

A genome screen for linkage in Australian sibling-pairs with multiple sclerosis

et al. 2002

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The role of genetic factors in determining susceptibility to multiple sclerosis is well established but, despite the global distribution of the disease, systematic efforts to locate susceptibility genes have concentrated exclusively on populations from the Northern Hemisphere. We performed a genome wide screen of linkage in the Australian population using a panel of 397 microsatellite markers in 54 affected sibling-pairs. Multipoint linkage analysis revealed four regions of suggestive linkage (on chromosomes 2p13, 4q26-28, 6q26 and Xp11) and 18 additional regions of potential linkage 4q24, 6q27, 9q21, 16p13, 16p11, 17p13, 18p11,. Our results contribute to the available data adding new provisional regions of linkage as well as increasing support for areas previously implicated in genetic susceptibility to multiple sclerosis.

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“…Most studies have demonstrated that females are more predisposed to MS than males, with predominance of cases in patients of Caucasian relative to African descent (ARRUDA et al, 2001;CARDOSO et al, 2006;FRAGOSO;PERES, 2007;FINKELSZTEJN et al, 2009). Although, it has been established that immigrants from areas of elevated risk for MS who have migrated, before 16 years-of-age, to a low-risk geographical location are likely to maintain their risk-factor (DEAN et al, 1976), this phenomenon was not investigated in the epidemiological studies analysed considering the impact of European immigration on the development of Brazil. Further, epidemiological surveys to exclude the possibility of CDV having any effect on MS in Brazil were not localized.…”

Section: Public Health Concernsmentioning

confidence: 99%

Epidemiological features and the neuropathological manifestations of canine distemper virus-induced infections in Brazil: a review

et al. 2012

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This review provides a critical review of current epidemiological trends of canine distemper virus (CDV) and syndromes related to canine distemper encephalitis (CDE) with specific reference to the situation in Brazil. Epidemiological data relative to susceptible animal populations, prevalence, seasonal occurrence, and age-related patterns associated with CDV are discussed. The participation of mongrel dogs in maintaining CDV within rural and semi-urban canine populations and their importance in the epidemiology of canine distemper is highlighted. The economic impact of treating the clinical manifestations associated with CDV-induced infections in Brazil is estimated. Additionally, neurological and neuropathological manifestations of CDV in Brazil are discussed, and a novel manifestation of CDE is proposed. Key words: Dog, canine distemper, epidemiology, neuropathology ResumoEsse manuscrito apresenta uma revisão crítica das tendências epidemiológicas associadas a cinomose canina (CDV) e às síndromes relacionadas à encefalite por cinomose com referência específica à situação no Brasil. Os dados epidemiológicos relativos às populações de animais suscetíveis, prevalência, sazonalidade e os padrões relacionados à idade foram discutidos. Também é enfocada nessa revisão a participação de cães de rua na manutenção do CDV nas populações caninas nas áreas rurais e nas regiões semiurbanas e a sua importância na epidemiologia da cinomose. Foi ainda estimado o impacto econômico relacionado ao tratamento das manifestações clínicas associadas à cinomose no Brasil. Adicionalmente, as manifestações neurológicas e neuropatológicas da cinomose são discutidas e uma manifestação neuropatológica inédita da infecção é sugerida.

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Multiple sclerosis among immigrants in Greater London.

Cited by 117 publications

References 3 publications

Multiple sclerosis genetics

Multiple sclerosis genetics

A genome screen for linkage in Australian sibling-pairs with multiple sclerosis

Epidemiological features and the neuropathological manifestations of canine distemper virus-induced infections in Brazil: a review

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