Multiple sclerosis genetics

A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches

“…Later, linkage to MS was tested for single nucleotide polymorphisms (SNPs) (Sawcer et al 2005), which usually consist of two alleles and are consequently less informative than microsatellites, but are more abundant in the genome. In spite of the higher genome coverage density, the study did not identify any region with statistically significant linkage to MS outside the HLA locus, pointing to a low sensitivity of the method (Cree 2014).…”

“…The analysis is performed using microarrays or more advanced techniques that allow a simultaneous genotyping at several tens of thousands to several millions of SNPs per genome (Cree 2014). Such experiments are comparatively inexpensive, allowing hundreds or thousands of patients to be genotyped in one study.…”

No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

“…Nonetheless, while there is mounting evidence that vitamin D exerts broad regulatory effects on cells of the adaptive and innate immune systems 2,3 , there is remarkably little evidence that treatment with vitamin D can influence MS evolution and prognosis 4,5,6,7 . So far, no clinical trial has provided any clear evidence that vitamin D alone can alter the course of an extremely complex disease like MS. Other vitamins 8,9,10 , genetic predisposition 11,12 and several environmental factors 13,14,15,16 may also play a substantial role in MS. However strong the role of vitamin D in the orchestra of factors associated with MS may be, this might be better seen in high-latitude countries.…”

HLA DRB5*01 Association Survey with Multiple Sclerosis in Khuzestan Province of Iran

“…Familial, twin and adoption studies support contribution of genetic factors to the disease [23,24]. Among all candidate genes the major histocompatibility complex (MHC) region is unambiguously associated with MS [24].…”