Multiple schwannomas in the oral floor: case report

Kubota, Yasutaka; Yanai, Yuta; Kumamaru, Wataru; Mori, Yoshihide

doi:10.1016/j.bjoms.2010.09.011

Cited by 10 publications

(5 citation statements)

References 10 publications

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“…Two hereditary syndromes that are related to SCH are NF2 and schwannomatosis (13). Oral SCHs are rarely associated with these syndromes (42), and the likelihood of having either one is greater when the plexiform variant is diagnosed (13). NF2 (OMIM #101000) is an autosomal dominant disorder caused by mutation of the NF2 gene on chromosome 22q12.2 (43).…”

Section: Discussionmentioning

confidence: 99%

Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature

Tamiolakis¹,

Chrysomali²,

Sklavounou‐Andrikopoulou³

et al. 2019

J Clin Exp Dent

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BackgroundOral neural tumors (ONTs) are rare lesions and represent reactive or neoplastic proliferations of nerve sheath cells. The purpose of the present study is to report the clinical, demographic and histopathologic features of 157 ONTs diagnosed in a single Oral Pathology Department and review the pertinent literature.Material and Methods157 cases of ONTs diagnosed during a 44-year period were retrospectively collected and the diagnosis was reconfirmed by studying representative haematoxylin and eosin stained tissue sections. The patients’ gender and age, as well as the main clinical features of the lesions, were retrieved from the biopsy submission forms.ResultsThe 157 ONTs represented approximately 0.4% of 35,590 biopsies accessioned during the study period. They affected 71 male and 86 female patients with a mean age of 38.4±18.8 years. They mainly appeared as asymptomatic nodules of normal or white colour on the tongue, lip mucosa and hard palate. The most common ONT was granular cell tumour (38.9%) followed by neurofibroma (19.7%), schwannoma (15.9%), traumatic neuroma (15.9%), palisaded encapsulated neuroma (8.3%) and nerve sheath myxoma (1.3%).ConclusionsThis study confirmed the rarity of ONTs. Their clinical characteristics mimic other oral lesions; thus, microscopic examination is the only mean to arrive at a definitive diagnosis. Key words:Oral neural tumors; oral neural neoplasms; neurofibroma; oral neurofibroma; schwannoma; oral schwannoma; neurilemmoma; oral neurilemmoma; granular cell tumor; oral granular cell tumor; traumatic neuroma; oral traumatic neuroma; palisaded encapsulated neuroma; oral palisaded encapsulated neuroma.

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Section: Discussionmentioning

confidence: 99%

Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature

Tamiolakis¹,

Chrysomali²,

Sklavounou‐Andrikopoulou³

et al. 2019

J Clin Exp Dent

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“…Ce sont des tumeurs encapsulées, ovoïdes, excentrées par rapport aux troncs nerveux. La forme unifocale reste la plus fréquente [2,3]. En règle générale, elles sont de taille modérée et de croissance lente [4,5].…”

Section: Discussionunclassified

Tumeur du nerf sciatique: neurinome ou neurofibrome? L'IRM peut-elle faire la différence?

Aoufir¹,

Hassani²,

Jidane³

et al. 2019

Pan Afr Med J

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Le nerf sciatique est la branche terminale du plexus sacré. La sciatalgie traduit une souffrance des racines nerveuses. La sciatique relève le plus souvent de l'origine dégénérative discale, la pathologie tumorale reste exceptionnelle. Il s'agit d'une tumeur nerveuse, révélée par un syndrome sciatique rebelle au traitement, diagnostiquée à l'IRM, chez un patient de 33 ans. La pathologie tumorale du nerf sciatique est rare, de diagnostic difficile. Les informations fournies par l'IRM sont cruciales car elles conditionnent l'approche chirurgicale.

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“…La forme unifocale reste la plus fréquente. La forme multifocale est souvent associée à une neurofibromatose de type II ou une schwannomatose (neurofibromatose de type III) [6][7][8][9].…”

Section: Discussionunclassified

Neurofibromatose, frontière entre schwannome et neurofibrome. À propos d’un cas clinique et revue de littérature

Bernardo

Butel

Langlois

et al. 2015

Med Buccale Chir Buccale

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Résumé -Introduction :Aujourd'hui, les pathologistes s'accordent à dire que schwannome, neurinome, neurilemmome et fibroblastome périneural sont des synonymes, ils font partie des neurofibromatoses de type II. Observation : Il s'agissait d'une patiente initialement adressée pour un schwannome bénin intramandibulaire. Cette lésion présentait des ressemblances sur le plan clinique et radiologique avec le schwannome, mais cette piste diagnostique n'était pas confirmée par le médecin anatomo-pathologiste. Discussion : Les anatomo-pathologistes distinguent cette tumeur du neurofibrome, retrouvé dans la neurofibromatose de type I. En effet, les neurofibromes prennent naissance à partir d'éléments conjonctifs (cellules de Schwann, fibroblastes et autres cellules du périnèvre) alors que les schwannomes sont une prolifération à partir de cellules de Schwann uniquement. Le diagnostic en est d'autant plus difficile et dépend de la pièce opératoire à analyser ainsi que de la compétence de l'anatomo-pathologiste. Conclusion : Cette observation clinique illustre la difficulté de la démarche diagnostique quand le clinicien fait face à des tumeurs peu fréquentes. Elle conforte la place de l'examen anatomo-pathologique dans la quête du diagnostic positif.Abstract -Neurofibromatosis, frontier between schwannoma and neurofibroma. A case report and literature review. Introduction: Today, pathologists agree that schwannoma, neurinoma, neurilemmoma and perineural fibroblastoma are synonymous; they are part of neurofibromatosis type II. Observation: A female patient presented mandibulary lesions initially diagnosed as a schwannoma. Indeed, the clinical and radiological aspects of these lesions showed similarities to schwannoma. However, this initial clinical diagnosis was not confirmed by the pathologist. Discussion: Pathologists differentiate schwannoma from neurofibroma, found in neurofibromatosis type I. Indeed, neurofibroma is formed by conjunctive elements (Schwann cells, fibroblasts and other cells of the perineurium), whereas schwannoma is exclusively a proliferation of Schwann cells. So, the diagnosis will be harder, and depends on the surgical specimen to be analysed and the ability of the pathologist. Conclusion: This clinical case illustrates the challenge of delivering a pertinent diagnosis and, finally, it highlights the importance of the histological examination for a positive diagnosis.

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Multiple schwannomas in the oral floor: case report

Abstract: We present a case of multiple schwannomas of the oral floor in a 62-year-old man, which met the diagnostic criteria of schwannomatosis.

Cited by 10 publications

References 10 publications

Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature

Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature

Tumeur du nerf sciatique: neurinome ou neurofibrome? L'IRM peut-elle faire la différence?

Neurofibromatose, frontière entre schwannome et neurofibrome. À propos d’un cas clinique et revue de littérature

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