Multiple Primary Melanoma Is Not a Distinct Biological Entity

Grob, Jean-Jacques

doi:10.1001/archderm.135.3.325

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Given the increased likelihood of improved surveillance resulting in thinner subsequent melanomas in patients following their initial diagnosis, 18,19 it is likely that the most important factor in long-term survival for MPM patients is the nature of their first melanoma. These results suggest agreement with Grob 24 that MPM is not a distinct biologic entity, and that long-term prognosis for individuals who survive their first melanoma is more dependent on compliance with self-skin examinations and frequent skin surveillance by an experienced provider to facilitate earlier detection of subsequent melanomas.…”

Section: Discussionsupporting

confidence: 82%

Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011)

Grossman

Farnham

Hyngstrom

et al. 2018

Journal of the American Academy of Dermatology

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Section: Discussionsupporting

confidence: 82%

Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011)

Grossman

Farnham

Hyngstrom

et al. 2018

Journal of the American Academy of Dermatology

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“…However, a bias is introduced by the fact that patients who present with poor prognosis primary lesions may simply not live long enough to develop subsequent primaries. 20 In our analysis, patients with MPM were more likely to be older. When the expected rate of melanoma is considered, younger patients showed the highest SIRs.…”

Section: Discussionmentioning

confidence: 76%

Second Primary Melanomas: Incidence and Outcome

Bower

Scoggins

Martin

et al. 2010

The American Surgeon

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The objective of this study was to determine the incidence of multiple primary melanomas (MPM) and other cancers types among patients with melanoma. Factors associated with development of MPM were assessed in a post hoc analysis of the database from a multi-institutional prospective randomized trial of patients with melanoma aged 18 to 70 years with Breslow thickness 1 mm or greater. Disease-free survival (DFS) and overall survival (OS) were evaluated by Kaplan-Meier analysis. Forty-eight (1.9%) of 2506 patients with melanoma developed additional primary melanomas. Median follow-up was 66 months. Except in one patient, the subsequent melanomas were thinner (median, 0.32 mm vs 1.50 mm; P < 0.0001). Compared with patients without MPM, patients with MPM were more likely to be older (median age, 54.5 vs 51.0 years; P = 0.048), to have superficially spreading melanomas (SSM) ( P = 0.025), to have negative sentinel lymph nodes ( P = 0.021), or to lack lymphovascular invasion (LVI) ( P = 0.008) with the initial tumor. On multivariate analysis, age ( P = 0.028), LVI ( P = 0.010), and SSM subtype of the original melanoma ( P = 0.024) were associated with MPM. Patients with MPM and patients with single primary melanoma had similar DFS (5-year DFS 88.7 vs 81.3%, P = 0.380), but patients with MPM had better OS (5-year OS 95.3 vs 80.0%, P = 0.005). Nonmelanoma malignancies occurred in 152 patients (6.1%). Ongoing surveillance of patients with melanoma is important given that a significant number will develop additional melanoma and nonmelanoma tumors. With close follow-up, second primary melanomas are usually detected at an early stage.

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Lentigines, nevi, and melanomas

Weedon¹

2010

Weedon's Skin Pathology

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Multiple Primary Melanoma Is Not a Distinct Biological Entity

Cited by 5 publications

References 13 publications

Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011)

Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011)

Second Primary Melanomas: Incidence and Outcome

Lentigines, nevi, and melanomas

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