Multiple Primary Malignant Neoplasms of Different Tissues or Organs

Moertel, Charles G.

doi:10.1007/978-3-642-87565-6_2

Cited by 11 publications

(15 citation statements)

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“…Warren and Gates [27] were the first to propose a diagnostic criterion for multiple primary neoplasms: each neoplasm must be histologically distinct, and the possibility of the neoplasms being metastases of each other must be ruled out. Moertel et al [28,29] then defined multiple primary neoplasms observed at the same time or within 6 months as synchronous multiple primary neoplasms, and neoplasms developing after a six-month interval as metachronous multiple primary neoplasms. Literature in regards to synchronous neoplasms is currently sparse and consists mostly of case reports and studies of selected populations.…”

Section: Discussionmentioning

confidence: 99%

Development of Marjolin’s ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping

2010

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Marjolin's ulcer defines the occurrence of malignancy, usually squamous cell carcinoma, in the setting of a post-traumatic scar often following thermal injury. The latency period from the time of injury to the onset of malignant transformation averages 30 years with the earliest documented incidence occurring 6 weeks after injury. In addition, the occurrence of multiple primary malignancies is a rare event. To our knowledge, we report the first case in the literature of a well-differentiated squamous cell carcinoma developing within 1 month of thermal injury to an elderly patient's right index finger with an incidental synchronous primary lung moderately differentiated squamous cell carcinoma that was morphologically and genetically different as confirmed by allelotyping. There is scant precedent literature on acute Marjolin's ulcers, and the most acute cases have arisen 6 weeks post-burn. There is also little published literature on the incidence of multiple primary malignancies. The quoted incidence of this event is <1%. Clinicians should be aware of the possibility of malignant transformation at the site of prior thermal injury. Biopsy remains the gold standard for diagnosis for Marjolin's ulcer. MRI is the most important diagnostic imaging tool because it will demonstrate the margins and extent of the lesion. Due to the aggressive nature of Marjolin's ulcer, treatment is usually surgical and dependent upon grading. When multiple lesions are detected after staging of a presumed neoplasm, the possibility of multiple primary maligancies should be considered. Allelotyping is a process that can be utilized to determine if multiple masses are related.

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Section: Discussionmentioning

confidence: 99%

Development of Marjolin’s ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping

2010

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“…The criteria have used for the diagnosis of double primary malignancies, have primarily given by warren and gates (table 1) and refined later. (7)(8)(9)(10) 1.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study on Second Primary Malignancies Incidence in Regional Cancer Institute

R¹,

Nehru²

2015

jemds

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BACKGROUND:The cancer patients have a life time risk from developing another de novo malignancy, depending on various risk factors like inherited, iatrogenic, infective, and environmental. The malignancy patients could survive longer due to settling treatment modalities, and then likely develop a new metachronous malignancy. The purpose of this study was to investigate clinically useful information for effective screening for synchronous and metachronous second primary cancers and to identify a potential surveillance protocol. METHODS: The study has conducted over a 5 years period from 2008 to 2013. A hospital based retrospective gathering of data among the patients that have diagnosed with second malignancy. All patients that have diagnosed with a histological (HPE) second cancer as per warren and gates criteria have included. Various details like age, sex, site, stage, diagnosis of tumor, and synchronous or metachronous of tumor treatment have recorded. RESULTS: Out of 52 cases 10(19.23%) were synchronous and 42(80.7%) were metachronous. 35 (67.30%) were females and 17(32.69%) were males. the most common site of primary tumor was head and neck (16 cases 30.76%) followed by breast cancers (11 case 21.15%), among the second cancer most common site was gynecological caner (12 cases 23.07%) and gastrointestinal tract (11 cases 21.15%) as for as the primary cancer is concerned 34 patients (65.38%) were diagnosed in advanced stages (stage III and IV). The stage of the second tumors was also advanced 32 cases (61.53%) being in stage III, IV. Squamous cell carcinoma represented the most frequent histo pathological type in primary cancer 28 cases (53.84%) and also in the second tumor. 19 cases (36.53%). CONCLUSION: The incidence of double primary malignancy is not very rare, could occur synchronously or metachronously. After the recent0 diagnostic and staging modalities as well as progress in the management of common cancer, the detection of second primary malignancy has increased. Each patient must be informed about the risk of developing secondary malignancies after the first treatment and about the importance of reporting any new symptom which might occur. Careful monitoring ensures an early detection for secondary tumors, and, subsequently, an appropriate management.

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“…An important factor, as several investigators have suggested, is the individual genetic predisposition that, together with exposure to risk factors, may lead to the occurrence of multiple tumors in the respiratory and digestive tracts [7]. The observation of multiple primary malignant neoplasms (MPMN) was considered quite exceptional in the previous century [8].…”

Section: Introductionmentioning

confidence: 99%