Multiple Primary Malignancies in Renal Cell Carcinoma

Multiple synchronous malignancies are rarer than metachronous ones. Primary synchronous breast and renal cancer is even rare. Such a case requires strict exclusion of possible metastasis to either site and to confirm the primary nature of each malignancy for better outcome of management and survival benefit. Multiple primary synchronous malignancies may be due to shared genetic mutations if any common carcinogenic factor cannot be found. The role of estrogens in cases in which human renal carcinoma is associated with other primary tumours involving steroid-hormone target tissues, is tentative and can only be hypothesised due to paucity of such data in literature. One should consider the possibility of concomitant dual or multiple primary tumours in a patient presented with mass lesions at various sites, especially if one of the sites is the kidney. We present a case report of a patient with synchronous primary breast and renal cancer.

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“…Multiple primary synchronous malignancies may be due to shared genetic mutations if any common carcinogenic factor cannot be found [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Primary Malignancies in Breast and Kidney: A Rare Case Report

Kurlekar

Rayate

2014

Indian J Surg

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“…It has been reported in 2.3% of clinical and 8.1% of autopsy series [10]. RCC is the most common tumor found to coexist with other malignancies [1,10,12,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…RCC is the most common tumor found to coexist with other malignancies [1,10,12,13,14]. In different studies the incidence of second primary malignancy associated with RCC is reported to be 12%-27.4% [1,10,11,14]. About 19% of these tumors appeared synchronously [1].…”

Section: Discussionmentioning

confidence: 99%

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Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland

Ulamec¹,

Tomas²,

Perić-Balja³

et al. 2008

Pathology - Research and Practice

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“…Multiple primary malignant tumors (MPMTs) are rarely observed in clinical practice, however, certain fundamental factors for the potential etiology have been described in the literature, including the environment and behavior (tobacco, occupation, pollution and ultraviolet light), genetic predisposition (Li-Fraumeni or Beckwith-Wiedemann syndromes), previous medical treatment (radiotherapy or chemotherapy) and complex interaction between all these factors (1). The association between varying cancer types can be classified into two categories, which are dependent on the timing of their discovery.…”

Section: Introductionmentioning

confidence: 99%

A novel combination of triple metachronous malignancies of the kidney, oropharynx and prostate: A case report

et al. 2015

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Abstract. Synchronous or metachronous malignancies are a rare event, with an incidence rate that increases with age. The present study reports the case of a 70-year-old Caucasian male who was referred to the outpatient office of the Urology Unit, Sapienza University of Rome (Latina, Italy) due to lower urinary tract symptoms. An abdominal ultrasound investigation was performed that demonstrated the presence of a right renal mass. The patient underwent right radical nephrectomy, which resulted in the definitive diagnosis of clear cell type renal cell carcinoma. The patient was eventually diagnosed with triple primary metachronous cancer consisting of renal clear cell carcinoma, prostate adenocarcinoma and squamous cell carcinoma of the oropharynx (palatine tonsil). To the best of our knowledge, this combination of primary neoplasms has not previously been documented.

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Multiple Primary Malignancies in Renal Cell Carcinoma

Abstract: Breast, prostate, colorectal and bladder cancer as well as non-Hodgkin's lymphoma were the most common other primary malignancies. Men with renal cell carcinoma have an increased risk of subsequent bladder cancer.

Cited by 94 publications

References 20 publications

Synchronous Primary Malignancies in Breast and Kidney: A Rare Case Report

Synchronous Primary Malignancies in Breast and Kidney: A Rare Case Report

Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland

A novel combination of triple metachronous malignancies of the kidney, oropharynx and prostate: A case report

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