Synchronous Primary Malignancies in Breast and Kidney: A Rare Case Report

Abstract

Multiple synchronous malignancies are rarer than metachronous ones. Primary synchronous breast and renal cancer is even rare. Such a case requires strict exclusion of possible metastasis to either site and to confirm the primary nature of each malignancy for better outcome of management and survival benefit. Multiple primary synchronous malignancies may be due to shared genetic mutations if any common carcinogenic factor cannot be found. The role of estrogens in cases in which human renal carcinoma is associated with other primary tumours involving steroid-hormone target tissues, is tentative and can only be hypothesised due to paucity of such data in literature. One should consider the possibility of concomitant dual or multiple primary tumours in a patient presented with mass lesions at various sites, especially if one of the sites is the kidney. We present a case report of a patient with synchronous primary breast and renal cancer.

Synchronous breast carcinoma (with Paget’s disease) and renal cell carcinoma with tubercular axillary lymphadenitis: a rare presentation

“…6 The incidence of dual primary malignancy (any origin) is roughly 4-11%. 7,9 According to Jiao et al there have been 8 reported cases of synchronous breast primary malignancy coexisting with RCC. 10,18 Most of the multiple malignancies reported in literature are metastatic tumours or metachronous breast malignancy with RCC.…”

Co-existent breast and renal cancer

“…The concomitant presence of breast cancer with one or more other type of cancers such as the colon, vulva, lung, larynx, liver, uterus and kidneys has been presented in the literature (4). The association of kidney cancer with synchronous and metachronous cancer in similar organs has been reported in the literature (1,5). However, reports on synchronous breast and renal cancer are very uncommon (1,4).…”

“…The association of kidney cancer with synchronous and metachronous cancer in similar organs has been reported in the literature (1,5). However, reports on synchronous breast and renal cancer are very uncommon (1,4).…”

“…The occurrence of multiple cancers in one patient is a rare phenomenon, and the frequency of synchronous neoplasms is less common than that of metachronous tumors (1). Synchronous tumors are defined as presence of a second tumor at the same time with the first tumor or within the first 6 months following diagnosis (2).…”

Tailoring Immunotherapy Treatment of Synchronous Renal Cell Carcinoma (RCC) and Triple-Negative Breast Cancer (TNBC)

“…Synchronous tumors are defined as two tumors arising concurrently or within six months of diagnosis [1]. Reports of synchronous RCC and breast cancer are limited to nonmetastatic RCC and hormone receptor-positive infiltrative ductal carcinoma (IDC) treated with complete resection of each primary tumor followed by chemoradiation and hormone therapy [2, 3]. We present a case of tailored immunotherapy for a patient with concurrent metastatic RCC (mRCC) and triple-negative breast cancer (TNBC).…”