Multiple Primary Carcinomas with Esophageal Squamous Cell Cancer: Clinicopathologic Outcome

Abstract

The incidence of multiple primary carcinomas (MPCs) associated with esophageal cancer has increased. The purpose of this study was to analyze clinicopathologic findings for MPC and for only esophageal cancer (OEC). Of 157 patients with MPCs, 60 had synchronous cancer and 97 metachronous cancer. Another 42 patients had antecedent esophageal cancer (AEC), and 55 patients had subsequent esophageal cancer (SEC). We retrospectively analyzed the clincopathologic findings for patients in these categories. The incidence of early-stage carcinoma was higher in patients with MPCs than in those with an OEC. Of patients with MPCs, those with metachronous cancer had a higher rate of early-stage carcinoma than those with synchronous cancer. The 5-year survival rates were not significantly different for MPC and OEC patients. Patients with metachronous cancer had a significantly better prognosis than those with synchronous cancer (p = 0.017); and in the metachronous cancer group the prognosis was significantly better for patients with AEC than for those with SEC (p = 0.0005). Meticulous follow-up after treatment of a first cancer should be required to detect other early-stage carcinomas.

Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study

“…The frequency of synchronous or metachronous multiple gastric cancers in patients with previous gastric cancers was reported as 3-5 per 100 patient-years [18][19][20]. Moreover, it was reported that the frequency of synchronous or metachronous gastric cancers was 7.7 % in patients with esophageal cancer [21]. Therefore, we hypothesized that the frequency of cancerous lesions would be 5.0 % for patients with gastric cancer or esophageal cancer and calculated the required size of the screening sample to be at least 520 patients.…”

Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer

“…[3][4][5][6] Field carcinogenesis reveals that 10% to 20% of patients with head and neck cancers develop synchronous or metachronous esophageal cancers.…”

Treatment of esophageal-gastric double primary cancer by pedunculated remnant gastric interposition, esophageal-gastric anastomosis and gastrojejunal Billroth II anastomosis: A case report

“…Esophageal-gastric double primary cancer after 5-year survival rate of esophageal cancer is similar to that of simple esophageal cancer surgery or even higher (8,9). Therefore, surgery remains the preferred method of treatment.…”