Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study

Dohi, Osamu; Yagi, Nobuaki; Majima, Atsushi; Horii, Yusuke; Kitaichi, Tomoko; Onozawa, Yuriko; Suzuki, Kentaro; Tomie, Akira; Kimura-Tsuchiya, Reiko; Tsuji, Toshifumi; Yamada, Naotaka; Bito, N.; Okayama, Tetsuya; Yoshida, Naohisa; Kamada, Kazuhiro; Katada, Kazuhiro; Uchiyama, Kazuhiko; Ishikawa, Takeshi; Takagi, Tomohisa; Handa, Osamu; Konishi, Hideyuki; Naito, Yuji; Yanagisawa, Akio; Itoh, Yoshito

doi:10.1007/s10120-016-0620-6

Cited by 96 publications

(70 citation statements)

References 23 publications

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“…Magnifying BLI (M-BLI) is useful for evaluating mucosal microvessels and mucosal microstructures of EGC [17,18]. Furthermore, M-BLI is more accurate than C-WLI for diagnosing EGC according to the vessel plus surface (VS) classification system [19]. However, to date, no study has compared M-BLI and M-NBI in terms of endoscopic findings of EGC.…”

Section: Introductionmentioning

confidence: 99%

Magnifying Blue Laser Imaging versus Magnifying Narrow-Band Imaging for the Diagnosis of Early Gastric Cancer: A Prospective, Multicenter, Comparative Study

et al. 2017

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Background/Aims: The diagnostic efficacy of magnifying blue laser imaging (M-BLI) and M-BLI in bright mode (M-BLI-bright) in the identification of early gastric cancer (EGC) was evaluated for comparison to that of magnifying narrow-band imaging (M-NBI). Methods: This prospective, multicenter study evaluated 114 gastric lesions examined using M-BLI, M-BLI-bright, and M-NBI between May 2012 and November 2012; 104 EGCs were evaluated by each modality. The vessel plus surface classification system was used to evaluate the demarcation line (DL), microvascular pattern (MVP), and microsurface pattern (MSP). Results: M-BLI, M-BLI-bright, and M-NBI revealed a DL for 96.1, 98.1, and 98.1% and irregular MVP for 95.1, 95.1, and 96.2% of lesions, respectively, with no significant difference. Irregular MSP was observed by M-BLI, M-BLI-bright, and M-NBI in 97.1, 90.4, and 78.8% of lesions, respectively, with significant differences (p < 0.001). The proportion of moderately differentiated adenocarcinoma with irregular MSP on M-BLI and absent MSP on M-NBI was significantly higher than that with irregular MSP on M-BLI and M-NBI (35.0 and 9.9%, respectively; p = 0.002). Conclusion: M-BLI and M-BLI-bright provided excellent visualization of microstructures and microvessels similar to M-NBI. Irregular MSP in a moderately differentiated adenocarcinoma might be frequently visualized using M-BLI and M-BLI-bright compared with using M-NBI.

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Section: Introductionmentioning

confidence: 99%

Magnifying Blue Laser Imaging versus Magnifying Narrow-Band Imaging for the Diagnosis of Early Gastric Cancer: A Prospective, Multicenter, Comparative Study

et al. 2017

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“…This emphasizes the importance of image-based diagnoses in achieving an accurate diagnosis of EGC. A series of studies demonstrated that the combined use of magnifying endoscopy and IEEs was useful in discriminating cancerous from noncancerous mucosa [15][16][17][18][19]. Most of these studies investigated NBI-assisted diagnoses.…”

Section: Differential Diagnosis and Delineation With Ieementioning

confidence: 99%

Past and current trends in endoscopic diagnosis for early stage gastric cancer in Japan

Sumiyama

2016

Gastric Cancer

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Methodology for the diagnosis and staging of early gastric cancer (EGC) has improved in Japan since the development of the gastro-camera and determination of a definition of EGC. Imaging technology has been steadily evolving in the endoscopy field. Improvements in the resolution of standard endoscopy images used in screening and surveillance provide greater opportunities to find gastric cancer earlier. Image enhancement endoscopy (IEE), such as narrow band imaging (NBI), highlights mucosal structures and vascularity. In particular, when NBI is used with magnifying endoscopy, it reveals fine details of subtle superficial abnormalities of EGC that are difficult to recognize using standard white light endoscopy. IEE-assisted magnifying endoscopy has improved the accuracy of the differentiation of superficial gastric cancer as well as delineation of the diseased mucosa. The advanced imaging technology enables precise assessment of the risk of lymph node metastasis of EGC and is widely used to determine indications for endoscopic treatment. It is not an overstatement to say that this has become the basis for the current development and dissemination of endoscopic treatments. Moreover, the resolution of endoscopic imaging has been upgraded to the microscopy level by the development of endomicroscopy, including endocytoscopy and confocal laser endomicroscopy. Endomicroscopy allows real-time histological analysis of living tissue during routine endoscopy and may reduce the number of biopsies needed to reach the correct diagnosis, minimizing the risk of sampling errors.

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“…The combination of strong 410 nm laser light, weak 450 nm laser light, and fluorescent light enables blue laser imaging (BLI) via narrow-band light observation. Magnifying endoscopy with BLI is useful for evaluating mucosal surface information such as surface blood vessel and structure patterns (11)(12)(13)(14)(15). The present study reported that the diagnostic ability of magnifying BLI endoscopy in early gastric cancer is higher than that of conventional white light endoscopy and was similar to that of magnifying NBI endoscopy (15 Magnifying BLI is also potentially useful in distinguishing Hp-positive stomachs as magnifying NBI.…”

Section: Introductionmentioning

confidence: 58%

“…The system provides a high contrast clear view of fine mucosal and capillary structures. Diagnostic effectiveness of BLI endoscopy has been suggested in colorectal tumors and early gastric cancers (11,15). The current study presents new evidence that magnifying BLI endoscopy is useful in distinguishing Hp-positive stomach.…”

Section: Discussionmentioning

confidence: 74%

A comparative study of magnifying blue laser imaging and magnifying narrow-band imaging system for endoscopic diagnosis of Helicobacter pylori infection

Tahara

Takahama²,

Horiguchi

et al. 2017

Biomedical Reports

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Abstract.Helicobacter pylori (Hp) infection is a major cause of gastric cancer. The use of proton-pump inhibitors, anti-platelet and anti-coagulant has become widespread in the clinic. Thus, it would be clinically useful to distinguish Hp-positive stomachs by endoscopic findings alone. Blue laser imaging (BLI) is a new image-enhanced endoscopy technique that utilizes a laser light source developed for narrow-band light observation. We investigated the diagnostic ability of magnifying BLI endoscopy to distinguish Hp-positive stomach in cancer free subjects. The data were also compared to the diagnostic ability of magnifying narrow-band imaging (NBI) endoscopy. In total, 215 participants were randomly assigned to the NBI (n=112) and BLI (n=113) groups. The greater curvature of the gastric middle and upper corpus were carefully evaluated with magnifying NBI or BLI. Small, round pits, accompanied with regular honeycomb-like subepithelial capillary networks (SECNs), being regularly interspersed with collecting venules were considered as Hp infection negative, while enlarged or elongated pits with unclear SECNs or dense fine irregular vessels were considered as Hp infection positive. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the diagnosis of Hp infection for the NBI group was 0.97, 0.81, 0.87 and 0.95, respectively. Sensitivity, specificity, PPV and NPV for the BLI group was 0.98, 0.92, 0.93 and 0.98, respectively. There was no significant difference among the values for the NBI and BLI groups (all P>0.2). In conclusion, the diagnostic ability of magnifying BLI is acceptable, since it is similar to that of magnifying NBI.

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Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study

Cited by 96 publications

References 23 publications

Magnifying Blue Laser Imaging versus Magnifying Narrow-Band Imaging for the Diagnosis of Early Gastric Cancer: A Prospective, Multicenter, Comparative Study

Magnifying Blue Laser Imaging versus Magnifying Narrow-Band Imaging for the Diagnosis of Early Gastric Cancer: A Prospective, Multicenter, Comparative Study

Past and current trends in endoscopic diagnosis for early stage gastric cancer in Japan

A comparative study of magnifying blue laser imaging and magnifying narrow-band imaging system for endoscopic diagnosis of Helicobacter pylori infection

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