Multiple primary cancers in squamous cell cancer of the head and neck

Kotwall, Cyrus A.; Razack, Mohamed S.; Sako, Kumao; Rao, Uma

doi:10.1002/jso.2930400208

Cited by 48 publications

(23 citation statements)

References 13 publications

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“…Even with such advances in surgery, radiotherapy and chemotherapy for SCCHN patients, these tumors are associated with moderately high recurrence rates, common medical comorbidities, and a high frequency of second primary malignancies (SPM) 2, and the survival rates remain unchanged over the last 30 years3. The continued poor prognosis for SCCHN patients is partly attributed to the development of SPM4,5.…”

Section: Introductionmentioning

confidence: 99%

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck

Chen

Zafereo

et al. 2010

Cancer

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BACKGROUND p53 plays a critical role in cellular anti-cancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of the p53 results in an amino acid substitution and could influence p53 function. We hypothesized that p53 codon 72 polymorphism may be associated with risk of SPMs and SPM-free survival among patients with squamous cell carcinoma of the head and neck (SCCHN). METHODS A total of 1,271 patients, who were diagnosed with incident SCCHN between May 1995 and January 2007, were genotyped and followed for SPM development. Log-rank test and Cox proportional hazard models were used to compare SPM-free survival and SPM risk between the different genotype groups. RESULTS We found a significantly reduced SPM-free survival for patients with variant Pro72 allele compared with patients with Arg 72 homozygous genotype (Log-rank test, p = 0.005). Compared to SCCHN patients with the p53 72Arg/Arg genotype, there was a significantly greater risk of SPM associated with the p53 72Arg/Pro genotype (HR, 1.75, 95% CI, 1.17–2.61) and the combined p53 72Arg/Pro + Pro/Pro (HR, 1.58, 95%CI, 1.07–2.34). Furthermore, stratification analyses showed that the risk of SPM associated with p53 variant genotypes (Arg/Pro + Pro/Pro) was more pronounced in several subgroups. CONCLUSIONS Our findings suggest that p53 codon 72 polymorphism could be a risk marker for genetic susceptibility to SPM of patients with primary SCCHN.

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Section: Introductionmentioning

confidence: 99%

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck

Chen

Zafereo

et al. 2010

Cancer

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“…The poor prognosis for SCCHN patients has not significantly improved, partly because of the high frequency of second primary malignancies (SPM), which occurs in approximately 15% of SCCHN patients (2–4), although the diagnostic and therapeutic approaches for SCCHN patients have been improved.…”

Section: Introductionmentioning

confidence: 99%

FAS and FASLG Genetic Variants and Risk for Second Primary Malignancy in Patients with Squamous Cell Carcinoma of the Head and Neck

Lei

Wang

Liu

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Single-nucleotide polymorphisms in the promoter region of the FAS and FASLG may alter the transcriptional activity of these genes. We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN).Methods: We used log-rank test and Cox proportional hazard models to assess the association of the four single-nucleotide polymorphisms (FAS -1377 G > A, FAS -670 A > G, FASLG -844 C > T, and FASLG -124 A > G) with the SPM-free survival and SPM risk among 1,286 incident SCCHN patients.Results: Compared with patients having the FAS -670 AA or the FASLG -844 CC genotypes, the patients having variant genotypes of FAS -670 AG/GG or FASLG -844 CT/TT genotypes had significantly increased risk for SPM, respectively. A trend for significantly increased SPM risk with increasing number of risk genotypes of the four polymorphisms was observed in a dose-response manner. Moreover, the patients with three or four combined risk genotypes had an ∼1.8-or 2.5-fold increased risk for developing SPM compared with patients with zero or one risk genotypes, respectively.Conclusions: Our results suggest a modestly increased risk for SPM after index SCCHN with FAS -670 A > G and FASLG -844 C > T polymorphisms and an even greater risk for SPM with multiple combined FAS and FASLG risk genotypes.Impact: The FAS and FASLG polymorphisms may serve as a susceptible marker for SCCHN patients at high SPM risk. Cancer Epidemiol Biomarkers Prev; 19(6); 1484-91. ©2010 AACR.

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“…In contrast, an LR is a tumor appearing within the first 3 years and located within 2 cm from the primary tumor and having the same histological aspect. The annual incidence of SPTs is about 4 % for head and neck cancer [80,[82][83][84][85][86][87], but is even higher for cancers of the oral cavity, ranging between 12.5 and 30 % in different places and centers [83,84,88,89]. A difference between LRs and SPTs has been observed also in terms of survival rate, which is markedly decreased in patients with LR compared with patients with SPT.…”

Section: Local Recurrences and Margin Statusmentioning

confidence: 89%

Open questions and novel concepts in oral cancer surgery

Tirelli

Zacchigna

Biasotto

et al. 2015

Eur Arch Otorhinolaryngol

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The persistence of cancerous cells after surgery in oral squamous cell carcinoma (OSCC) represents a major challenge, as it often leads to local recurrences and secondary primary tumors, which are eventually responsible for a large proportion of deaths. This persistence is currently evaluated by histological analyses. In this review we discuss some important pitfalls of the histopathological analysis, such as margin evaluation, specimen shrinkage and T staging. In addition, we critically analyze the appropriateness of current surgical techniques in relation to the concept of field cancerization. Finally, we describe some novel imaging and molecular approaches, which might be useful in tailoring surgical resections and encourage the use of OSCC animal models to explore and provide proof of concept of the feasibility and potential clinical utility of innovative surgical protocols.

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Multiple primary cancers in squamous cell cancer of the head and neck

Cited by 48 publications

References 13 publications

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck

FAS and FASLG Genetic Variants and Risk for Second Primary Malignancy in Patients with Squamous Cell Carcinoma of the Head and Neck

Open questions and novel concepts in oral cancer surgery

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