Multiple primäre Neoplasien im urologischen Krankengut

Multiple Primary Neoplasms in Patients with Testicular Germ Cell Tumor

“…The figure in this latter population is 3.3% (95% Cl ± 0.5%) and at first glance this is not different from the figure found in the present study. However, one has to consider that patients with urologic cancer are usually much older than patients with testis cancer; in the study referred to [30], the mean age of patients with urologic cancer was 68 years, which is more than two decades higher than the age of GCT patients in the present study (42 years). Thus, it appears that patients with testicular GCT are indeed at a slightly increased risk of a second malignancy and this confirms the conclusions drawn from studies using cancer registry data [6,17,27,28].…”

“…The median interval between GCT and NTM is at variance with the findings in subsequent bilateral testicular tumors since more than 50% of all bilateral tumors have occurred within 5 years and more than 80% have occurred after an interval of 10 years [45]. In the total population of male patients with urologic can cer, second tumors arise after an mean interval of 2.5 years [30], This high incidence of early second tumors is probably age-dependent since the patients with urologic cancer are on average two decades older than GCT patients, and older patients have a generally increased risk of cancer [9].…”

“…25 nontesticular malignancies occurred in a total of 23 patients (3.9%; 95% confidence intervals ± 1.6%), 3 of whom have been discussed in previous communications [30][31][32], Among the 25 NTMs, there were 16 histological ly different tumors. Bladder cancer and bronchogenic car cinoma occurred each 3 times.…”

“…To assess the question if a patient with testicular GCT has an increased risk of developing more than one cancer we compared the prevalence of multiple neoplasms in GCT patients to the prevalence found in a population of patients with urologic cancers treated in the same institu tion and during the same time-span [30]. The figure in this latter population is 3.3% (95% Cl ± 0.5%) and at first glance this is not different from the figure found in the present study.…”

Renal Cell Cancer and Concomitant Transitional Cell Cancer of the Renal Pelvis and Ureter in the Same Kidney – Report of 4 Cases and Review of the Literature

“…Simultaneous occurrence of renal cell cancer and transi tional cell cancer is an extremely rare entity with only 15 cases having been reported.The simultaneous occurrence of renal cell cancer (RCC) and transitional cell cancer (TCC) in the same kid ney is a classic example of multiple primary neoplasms as defined by Warren and Gates [1]: 'Each of the tumors must present a definite picture of malignancy, each must be distinct, and the probability of one being the metastasis of the other must be excluded'.Multiple primary neoplasms are observed in approxi mately 3-10% of all patients with urologic cancer [2][3][4][5]. Simultaneous occurrence of RCC and TCC in the same kidney is an entity that can cause great diagnostic dilem mas because the second primary neoplasm in the drainage system is easy to miss, and so multiple primary tumors in different compartments of the kidney have been consid ered to have a worse prognosis than either of the tumors alone.…”