Renal Cell Cancer and Concomitant Transitional Cell Cancer of the Renal Pelvis and Ureter in the Same Kidney – Report of 4 Cases and Review of the Literature

Wegner, H; Bornhöft, Gudrun; Dieckmann, Klaus‐Peter

doi:10.1159/000282535

Cited by 19 publications

(7 citation statements)

References 16 publications

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“…Hematuria was the most common presentation seen in 90% of the cases. There was a male predominance (2:1) and tumors were located more commonly on the left side (3:1) [1,2]. A recent retrospective study failed to demonstrate a higher histopathological grade of malignancy of these tumors when they occur synchronously or alone.…”

Section: Discussionmentioning

confidence: 99%

Synchronous ipsilateral conventional renal cell and transitional cell carcinoma

et al. 2004

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Simultaneous occurrence of renal cell carcinoma (RCC) and transitional cell carcinoma (TCC) in the same kidney is unusual. We report a 61-year-old man with ipsilateral synchronous renal adenocarcinoma and renal pelvic TCC. He was referred to our department for gross hematuria and right flank pain. CT and MRI studies revealed a 57 x 50 mm irregular and infiltrative upper right kidney mass with necrotic components. A right radical nephrectomy was done. Pathological diagnosis was a high grade tumor originating from just beneath the intact urothelium of renal pelvis and infiltrating through the parenchyma showing solid and occasional tubular growth patterns. A second tumor in close proximity to the first was reported as well differentiated RCC. This is a rare case of combined renal malignancies.

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Section: Discussionmentioning

confidence: 99%

Synchronous ipsilateral conventional renal cell and transitional cell carcinoma

et al. 2004

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“…2 There are about 100 cases reported in the English, Spanish, Japanese and Korean literature. [2][3][4][5][6][7][8] None of them were managed with organ preservation. Rather, radical nephroureterectomy or nephrectomy was performed for definitive treatment.…”

Section: Discussionmentioning

confidence: 99%

Double jeopardy? Renal sparing management of simultaneous ipsilateral renal cell carcinoma and urothelial carcinoma

Bay

Black

2013

CUAJ

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The occurrence of renal cell carcinoma (RCC) and urothelial carcinoma (UC) synchronously in the same kidney is exceedingly rare. All reported cases have been managed with either nephroureterectomy or nephrectomy. We report on a patient who required renal-sparing management of his double malignancy, including open partial nephrectomy of his pT1a RCC and endoscopic laser ablation of his low-grade Ta renal pelvis UC. After 4 years, the patient is in good health and disease-free under strict surveillance. It, therefore, would appear justified to combine partial nephrectomy for RCC and endoscopic management of UC in the same kidney of an appropriately selected patient.

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“…Five cases of concomitant RCC and UC of the renal pelvis arising in the same kidney were reported by Wegner et al [22] in 1993, but they did not specify the histologic type of the RCC. Our cases could be distinguished from those by thorough sampling of the neoplasms and detection of in-situ dysplastic changes and their continuity with the invasive UC, which focally grew as clear squamous cells inside preexisting renal tubules.…”

Section: Discussionmentioning

confidence: 99%

Renal Pelvic Carcinoma with Unusual Appearance Simulating Amyloidosis (Myeloma Kidney)

Hes

Michal²,

Kinkor

et al. 2002

Int J Surg Pathol

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We describe 5 cases of urothelial carcinoma (UC) of the renal pelvis, which grew in a distinctive gross and microscopical pattern into the renal parenchyma. Five patients (2 men and 3 women, mean age 67.4 years) underwent nephrectomy for vague clinical findings. The cut surface of the tumor was white to light gray and the consistency was elastic. The corticomedullary border was indistinct, resulting in an appearance that suggested amyloidosis or myeloma. The renal pelvis showed normal mucosa with areas of dysplastic changes. The tumors spread from the renal pelvis in a diffuse and irregular, infiltrative pattern and surrounded intact glomeruli. Detailed sampling of invasive tumor component showed foci of UC with transitions to clear squamous cells. The predominant clear squamous neoplastic cells had foci of granular eosinophilic cytoplasm and resembled conventional renal cell carcinoma. Four patients were alive and without signs of the disease for 5 months to 4 years after nephrectomy; 1 died of generalized tumor 7 months after nephrectomy. The unusual gross and microscopic features result in varied problems in differential diagnosis, which are discussed herein.

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Renal Cell Cancer and Concomitant Transitional Cell Cancer of the Renal Pelvis and Ureter in the Same Kidney – Report of 4 Cases and Review of the Literature

Cited by 19 publications

References 16 publications

Synchronous ipsilateral conventional renal cell and transitional cell carcinoma

Synchronous ipsilateral conventional renal cell and transitional cell carcinoma

Double jeopardy? Renal sparing management of simultaneous ipsilateral renal cell carcinoma and urothelial carcinoma

Renal Pelvic Carcinoma with Unusual Appearance Simulating Amyloidosis (Myeloma Kidney)

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