Multiple Postnatal Infections in Newborns Born Preterm Predict Delayed Maturation of Motor Pathways at Term-Equivalent Age with Poorer Motor Outcomes at 3 Years

Glass, Torin; Chau, Vann; Grunau, Ruth E.; Synnes, Anne; Guo, Ting; Duerden, Emma G.; Foong, Justin; Poskitt, Kenneth J.; Miller, Steven P.

doi:10.1016/j.jpeds.2017.12.041

Cited by 29 publications

(23 citation statements)

References 50 publications

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“…Importantly, up to 50% of these infants exhibited neurodevelopmental impairments at two years of age, even when the infection was only evident clinically (i.e., without positive cultures) [62][63][64]. Repeated infections, recurrent inflammation (e.g., repeated inflammatory stimuli from mechanical ventilation), or a combination of antenatal infection followed by postnatal infection can further increase the risk of adverse neurodevelopmental outcomes [14,65,66].…”

Section: Postnatal Infectionmentioning

confidence: 99%

Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury

Prasad

Gunn

Davidson

et al. 2021

IJMS

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Despite the prevalence of preterm brain injury, there are no established neuroprotective strategies to prevent or alleviate mild-to-moderate inflammation-related brain injury. Perinatal infection and inflammation have been shown to trigger acute neuroinflammation, including proinflammatory cytokine release and gliosis, which are associated with acute and chronic disturbances in brain cell survival and maturation. These findings suggest the hypothesis that the inhibition of peripheral immune responses following infection or nonspecific inflammation may be a therapeutic strategy to reduce the associated brain injury and neurobehavioral deficits. This review provides an overview of the neonatal immunity, neuroinflammation, and mechanisms of inflammation-related brain injury in preterm infants and explores the safety and efficacy of anti-inflammatory agents as potentially neurotherapeutics.

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Section: Postnatal Infectionmentioning

confidence: 99%

Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury

Prasad

Gunn

Davidson

et al. 2021

IJMS

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“…Considering that repercussions of antenatal infection may appear later in childhood, it is important to follow up neurodevelopment as children grow older. The current gold standard method for neurodevelopment analysis are the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), which are accepted as a valid and reliable measure for children between 1 and 42 months of age and has been used for many years in different populations, for example, in preterm children 3,4 . Continuous monitoring of neurodevelopment in the present cohort enables drafting of improved health care strategies within the Brazilian Unified Health System.…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure

Aizawa¹,

Caron²,

Souza³

et al. 2021

Rev. saúde pública

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We report cognitive, language and motor neurodevelopment, assessed by the Bayley-III test, in 31 non-microcephalic children at age 3 with PCR-confirmed maternal Zika virus exposure (Rio de Janeiro, 2015–2016). Most children had average neurodevelopmental scores, however, 8 children (26%) presented delay in some domain. Language was the most affected: 7 children (22.6%) had a delay in this domain (2 presenting severe delay). Moderate delay was detected in the cognitive (3.2%) and motor (10%) domains. Maternal illness in the third trimester of pregnancy and later gestational age at birth were associated with higher Bayley-III scores. Zika-exposed children require long-term follow-up until school age.

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“…Its normative sample was based on 2003 children in forty-six states of the United States and one Canadian province [22] .The PDMS-2 is suitable for assessing various populations of children at a high risk for motor delays. It has a high degree of reliability and validity regarding child development in China [23][24][25] , but few studies have applied the PDMS-2 to children in PICUs. The PDMS-2 is composed of four subtests: reflex, stationary, locomotion, and object manipulation, and each subtest contributes to the gross motor quotient (GMQ) score.…”

Section: Methodsmentioning

confidence: 99%

Gross Motor Developmental Function Outcomes in Infantile and Toddler Pediatric Intensive Care Unit Survivors

Yang

Feng

et al. 2019

Preprint

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Background In recent years, increasing studies have focused on motor function/dysfunction in PICU survival. However, most studies have focused on adults and older children. This study aims to investigate gross motor developmental function outcomes in infantile and toddler pediatric intensive care unit (PICU) survivors and the factors associated with gross motor developmental functions.Methods Thirty-five eligibles were divided into dysfunctional (n=24) or non-dysfunctional (n=11) group. Baseline gross motor function for all participants before PICU admission was measured via the Age and Stages Questionnaires, Third Edition (ASQ-3). The Peabody Developmental Motor Scales, Second Edition (PDMS-2) was used to evaluate gross motor development function before PICU discharge.Results The gross motor developmental dysfunction incidence was 68.6% in this study. Linear correlation analysis showed that the GMQ was positively correlated with pediatric critical illness score (PCIS, r=0.621, P<0.001), and negatively correlated with length of PICU stay (r=-0.556, P=0.001), days sedated (r=-0.602, P<0.001), days on invasive mechanical ventilation (IMV; r=-0.686, P<0.001), and days on continuous renal replacement therapy (CRRT; r=-0.538, P=0.001). Linear regression analysis showed that IMV days (β=-0.736, P=0.001), sepsis (β=-18.111, P=0.003) and PCIS (β=0.550, P=0.021) were independent risk factors for gross motor developmental dysfunctionConclusions Gross motor developmental dysfunction in infantile and toddler PICU survivors are more common and may be exacerbated by experiences associated with longer IMV days and increasing illness severity combined with sepsis.

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Multiple Postnatal Infections in Newborns Born Preterm Predict Delayed Maturation of Motor Pathways at Term-Equivalent Age with Poorer Motor Outcomes at 3 Years

Cited by 29 publications

References 50 publications

Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury

Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury

Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure

Gross Motor Developmental Function Outcomes in Infantile and Toddler Pediatric Intensive Care Unit Survivors

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