Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells

Xu, Yang; Ching, Yick–Pang; Zhou, Yuan; Chiu, Jen‐Fu; Chen, Feng; He, Qing‐Yu

doi:10.1016/j.jprot.2011.08.014

Cited by 22 publications

(22 citation statements)

References 44 publications

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“…Such antitumor activity in part motivated the successful isolation of Tubeimoside 1 (TBMS 1), a triterpenoid saponin. And subsequent studies confirmed that TBMS 1 can indeed inhibit the growth of several human cancer cell lines including HeLa cells [19, 20] and human promyelocytic leukemia (HL-60) [21]. These studies appear to suggest that TBMS 1 may be a potential candidate as a novel antitumor drug.…”

Section: Introductionmentioning

confidence: 88%

Research on the Interaction between Tubeimoside 1 and HepG2 Cells Using the Microscopic Imaging and Fluorescent Spectra Method

Lin

Chang-bin

et al. 2014

Computational and Mathematical Methods in Medicine

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The treatment of cancer draws interest from researchers worldwide. Of the different extracts from traditional Chinese medicines, Tubeimoside 1 (TBMS 1) is regarded as an effective treatment for cancer. To determine the mechanism of TBMS 1, the shape/pattern of HepG2 cells based on the microscopic imaging technology was determined to analyze experimental results; then the fluorescent spectra method was designed to investigate whether TBMS 1 affected HepG2 cells. A three-dimensional (3D) fluorescent spectra sweep was performed to determine the characteristic wave peak of HepG2 cells. A 2D fluorescent spectra method was then used to show the florescence change in HepG2 cells following treatment with TBMS 1. Finally, flow cytometry was employed to analyze the cell cycle of HepG2 cells. It was shown that TBMS 1 accelerated the death of HepG2 cells and had a strong dose- and time-dependent growth inhibitory effect on HepG2 cells, especially at the G2/M phase. These results indicate that the fluorescent spectra method is a promising substitute for flow cytometry as it is rapid and cost-effective in HepG2 cells.

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Section: Introductionmentioning

confidence: 88%

Research on the Interaction between Tubeimoside 1 and HepG2 Cells Using the Microscopic Imaging and Fluorescent Spectra Method

Lin

Chang-bin

et al. 2014

Computational and Mathematical Methods in Medicine

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“…Cytoplasmic sequestration of Cip1/p21, Cdc25C induction with dyspolymerization of tubulin contributed to tubeimoside-1-induced G2/M phase arrest coincided with reduction in G0/G1 phase in HeLa cells. Furthermore, Cdc2 and cyclin B1 expression was inhibited while Chk2 phosphorylation was enhanced [38] ( Figure 4). Nuclear proteomic study in EC109 cells has declared the presence of modified proteins linked with cellular proliferation and mitochondrial function.…”

Section: Tubeimoside-1 and Cell Cycle Arrestmentioning

confidence: 97%

Tubeimoside-1, Triterpenoid Saponin, as a Potential Natural Cancer Killer

Zafar

Sarfraz

Rasul

et al. 2018

Natural Product Communications

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Nature, an expert craftsman of molecules, has generated extensive array of bioactive molecular entities. It persists as an inexhaustible resource for discovery of drugs and supplied enormous scaffold diversification for development into effectual drugs to treat multiple pathological conditions. This review provides an update on the sources, biological, and pharmacological effects of nature's gift, a triterpenoid saponin, tubeimoside-1 which is a major bioactive constituent of the bulb of Bolbostemma paniculatum. Tubeimoside-1 is known to possess various pharmacological properties such as anti-cancer, anti-HIV, and antiinflammatory. Recently, anti-proliferative potential of tubeimoside-1 has been widely studied. The present review article seeks to cover the recent developments of tubeimoside-1's pharmacological position in the arena of herbal drugs, providing an insight into its current status in therapeutic pursuits. This anti-cancer triterpenoid saponin fight cancer progression by induction of apoptosis, cell cycle arrest, and inhibiting metastasis by specifically targeting multiple signaling pathways those are usually deregulated in various cancers. The reported data recommend tubeimoside-1's mutitarget activity in preference to single effect that may perform an imperative role towards developing tubeimoside-1 into potential pharmacological drug.

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“…Here, tubeimoside-1 was found to induced cell cycle arrest at G2/M phase, presumably by inhibiting the expression levels of selected cyclins, as well as interfering with the post-translational modifications (Xu et al, 2011). On the other hand, CIL-102 (an alkaloid derivative) was linked specifically to inhibit cancer cells proliferation by up-regulating the N-terminal kinases (JNK1/2) and mTOR signaling pathways (Teng et al, 2013).…”

Section: Phytochemical-mediated Cancer Protein Targetsmentioning

confidence: 98%

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

Wong

Tan

Chai

2015

Critical Reviews in Food Science and Nutrition

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Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents.

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Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells

Cited by 22 publications

References 44 publications

Research on the Interaction between Tubeimoside 1 and HepG2 Cells Using the Microscopic Imaging and Fluorescent Spectra Method

Research on the Interaction between Tubeimoside 1 and HepG2 Cells Using the Microscopic Imaging and Fluorescent Spectra Method

Tubeimoside-1, Triterpenoid Saponin, as a Potential Natural Cancer Killer

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

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