Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

Abstract

Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents.

Application of enzyme-digested soy protein hydrolysate on hydroponic-planted lettuce: Effects on phytochemical contents, biochemical profiles and physical properties

“…Numerous studies have previously reported on how plant phytochencal contents are directly linked to their bioactivities and pharmacological potentials ( Cao et al, 2017 , Teng et al, 2019 , Wong et al, 2016 ). In order to determine the effect of protein hydrolysate (PH) treatments, the harvested hydroponic lettuce samples were firstly tested for the phytochemical contents in three categories, namely total phenolic content (TPC), total flavonoid content (TPC), and total hydroxycinnamic acid content (THC).…”

Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, A Health Care Strategy to Combat this Disease

“…58 These combinatorial studies could provide opportunities for phytochemicals to be developed into site-and targetspecific anticancer agents. 59…”

Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, a Health Care Strategy to Combat this Disease

“…The most successful discoveries are the vinca alkaloids (vinblastin and vincristine) from Catharanthus roseus. 23…”

“…58 These combinatorial studies could provide opportunities for phytochemicals to be developed into site-and targetspecific anticancer agents. 59 Nano formulations for optimal activity 62 miRNAs are involved in all stages of colorectal cancer. 63 Curcumin, resveratrol, quercetin, alpha-mangostin, Vitamin D, omega-3 PUFA have been reported with miRNA modulatory activity.…”