Multiple parameters required for diagnosis of COVID-19 in clinical practice

Lei, Pinggui; Fan, Bing; Mao, Jujiang; Wang, Pingxian

doi:10.1016/j.jinf.2020.03.016

Cited by 13 publications

(12 citation statements)

References 7 publications

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“…Abnormalities in the CT scans can be concomitant with disease progression and prognosis. But, not all the cases can be perfectly detected with CT scans (Lei et al, 2020). Therefore, it is essential to conduct molecular tests and consider travel history and clinical symptoms of the patient as well.…”

Section: Recent Diagnostic Techniquesmentioning

confidence: 99%

COVID-19: A promising cure for the global panic

Vellingiri

Jayaramayya

Iyer

et al. 2020

Science of The Total Environment

565

538

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Journal Pre-proof J o u r n a l P r e -p r o o f Acknowledgements: AbstractThe novel Coronavirus disease 2019 is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed.We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.

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Section: Recent Diagnostic Techniquesmentioning

confidence: 99%

COVID-19: A promising cure for the global panic

Vellingiri

Jayaramayya

Iyer

et al. 2020

Science of The Total Environment

565

538

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“…A better criterion standard for COVID-19 will certainly emerge and we propose some ideas in Table 2. 113,114 Temporal bias reflects variation in observed accuracy based on the period of time or stage of disease when index testing occurred. 115 In COVID-19 viral shedding is highest in the early stages of disease with the highest positive rates noted within the first week.…”

Section: Potential Diagnostic Biases Skew Observed Accuracymentioning

confidence: 99%

Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Examinations, Laboratory Tests, Imaging Accuracy, and Biases

Carpenter

Mudd

West

et al. 2020

Academic Emergency Medicine

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Objective Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged as a global pandemic in early 2020 with rapidly evolving approaches to diagnosing the clinical illness called coronavirus disease (COVID‐19). The primary objective of this scoping review is to synthesize current research of the diagnostic accuracy of history, physical examination, routine laboratory tests, real‐time reverse transcription–polymerase chain reaction (rRT‐PCR), immunology tests, and computed tomography (CT) for the emergency department (ED) diagnosis of COVID‐19. Secondary objectives included a synopsis of diagnostic biases likely with current COVID‐19 research as well as corresponding implications of false‐negative and false‐positive results for clinicians and investigators. Methods A Preferred Reporting Items for Systematic Reviews and Meta‐Analyses–Scoping Review (PRISMA‐ScR)–adherent synthesis of COVID‐19 diagnostic accuracy through May 5, 2020, was conducted. The search strategy was designed by a medical librarian and included studies indexed by PubMed and Embase since January 2020. Results A total of 1,907 citations were screened for relevance. Patients without COVID‐19 are rarely reported, so specificity and likelihood ratios were generally unavailable. Fever is the most common finding, while hyposmia and hypogeusia appear useful to rule in COVID‐19. Cough is not consistently present. Lymphopenia is the mostly commonly reported laboratory abnormality and occurs in over 50% of COVID‐19 patients. rRT‐PCR is currently considered the COVID‐19 criterion standard for most diagnostic studies, but a single test sensitivity ranges from 60% to 78%. Multiple reasons for false‐negatives rRT‐PCR exist, including sample site tested and disease stage during which sample was obtained. CT may increase COVID‐19 sensitivity in conjunction with rRT‐PCR, but guidelines for imaging patients most likely to benefit are emerging. IgM and IgG serology levels are undetectable in the first week of COVID‐19, but sensitivity (range = 82% to 100%) and specificity (range = 87% to 100%) are promising. Whether detectable COVID‐19 antibodies correspond to immunity remains unanswered. Current studies do not adhere to accepted diagnostic accuracy reporting standards and likely report significantly biased results if the same tests were to be applied to general ED populations with suspected COVID‐19. Conclusions With the exception of fever and disorders of smell/taste, history and physical examination findings are unhelpful to distinguish COVID‐19 from other infectious conditions that mimic SARS‐CoV‐2 like influenza. Routine laboratory tests are also nondiagnostic, although lymphopenia is a common finding and other abnormalities may predict severe disease. Although rRT‐PCR is the current criterion standard, more inclusive consensus‐based criteria will likely emerge because of the high false‐negative rate of PCR tests. The role of serology and CT in ED assessments remains undefined.

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“…18 Manifestaciones Clínicas y Diagnóstico Dado que se ha informado que la transmisión se da de persona a persona, 19 es importante diagnosticar con precisión a los pacientes sospechosos de padecer Los resultados de laboratorio son considerados como una ayuda al momento de diagnosticar la infección por SARS-CoV-2. 23 Lei et al, 20 del Hospital Afiliado de la Universidad de Medicina de Guizhou, Guiyang, China informó que en el hospital donde trabaja encontraron que de 14 pacientes confirmados con COVID-19, 12 pacientes (85.71%) presentaron un recuento de glóbulos blancos normal, el porcentaje de linfocitos (8/14, 57.14%) y monocitos (9/14, 64.29%) con tendencia a disminuir.…”

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“…Por ello, el conocer los resultados de laboratorio les fue útil para diagnosticar la infección por SARS-CoV-2. 20 Tratamiento Hasta la actualidad no se ha encontrado un tratamiento específico para este tipo de enfermedad. Pero si es importante señalar que entre el 23 de enero y el 08 de marzo del 2020 han sido registrados 382 ensayos clínicos de los cuales 379 fueron registrados en China, en la Plataforma Internacional de Registro de Ensayos Clínicos (ICTRP) de la OMS.…”

unclassified

“…de COVID-19 con el fin de establecer un tratamiento oportuno y aislamiento. Gran parte de los estudios y la epidemiología indica que los síntomas que se presentan en este tipo de pacientes son primordialmente fiebre, tos no productiva, en algunos pacientes la diarrea puede preceder a estos síntomas 20. En la actualidad, la Reacción en Cadena de la Polimerasa con Transcriptasa Reversa (del inglés reverse transcription polymerase chain reaction, RT-PCR), es una variante de PCR, técnica usada en biología molecular que tiene como objetivo generar copias de ADN.…”

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Coronavirus and the dental office

Ramos¹

2020

J Oral Res

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Resumen Hasta el 27 de marzo del 2020 la Organización Mundial de la Salud ya había publicado 67 informes sobre el estado del coronavirus donde reporta a nivel mundial 509164 casos confirmados, 46484 nuevos casos confirmados, 23335 muertos y 2501 nuevos muertos. El odontólogo juega un papel importante ya que los dispositivos que utiliza en la práctica dental tienen el potencial de generar aerosoles, están constantemente contaminados y si no se lleva a cabo una buena desinfección y esterilización se puede llegar a desarrollar una infección cruzada. El presente artículo tiene como objetivo informar sobre esta nueva enfermedad a la comunidad en general y en especial al profesional que vela por la salud bucal de la población. Ya que el odontólogo debe ser capaz de evaluar los casos sospechosos infectados por el nuevo coronavirus. Al mismo tiempo, se pretende que el odontólogo tome conciencia acerca de esta nueva enfermedad y afiance los conocimientos básicos de bioseguridad, para ponerlo en práctica en la consulta odontológica. Cronología El 31 de diciembre del 2019 en la Ciudad de Wuhan, China, las autoridades sanitarias informaron 27 personas con diagnosticadas con infección por Síndrome Respiratorio Agudo Severo Coronavirus 2 (SARS-CoV-2). El 1 de enero del 2020 China cierra el mercado de mariscos de Wuhan, ya que se sospechaba que los animales que vendían ahí podían ser la fuente de la infección. El 7 de enero del 2020 la Organización Mundial de la Salud identificó como patógeno a un nuevo tipo de coronavirus, denominándolo SARS-CoV-2. 1,2 El 11 de enero la comisión de salud de Wuhan contabiliza 41 infectados y la primera muerte por este nuevo coronavirus. El 13 de enero Tailandia reporta su primer caso de coronavirus, 16 de enero el virus llega a Japón. El 23 de enero la OMS asegura que el coronavirus no es una emergencia internacional de salud pública, sin embargo, China ya había iniciado un aislamiento social. El 21 de enero del 2020 la Organización Mundial de la Salud publica su primer reporte, donde confirma 282 casos infectados por SARS-CoV-2. De los cuales 258 casos pertenecían a la provincia de Hubei en China, en ese entonces la Republica de Corea y Tailandia ya tenían 1 y 2 casos confirmados respectivamente. 3 El 24 de enero Francia registra el primer caso de coronavirus. El 30 de enero la OMS declara al coronavirus como una emergencia internacional de salud pública. 4 El 1 de febrero se reportan los primeros casos en Suecia, Rusia y España. El 7 de febrero muere el Dr. Li Wenliang quien el 30 de diciembre del 2019 intentó alertar a sus colegas sobre un virus similar al SARS-Cov. El 23 de febrero Italia anuncia su primera víctima. El 26 de febrero el virus llega a Sudamérica, específicamente a Brasil. El 9 de marzo Italia pone en práctica

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Multiple parameters required for diagnosis of COVID-19 in clinical practice

Cited by 13 publications

References 7 publications

COVID-19: A promising cure for the global panic

COVID-19: A promising cure for the global panic

Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Examinations, Laboratory Tests, Imaging Accuracy, and Biases

Coronavirus and the dental office

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