Multiple Papules and Plaques in a Patient With Ovarian Carcinoma

Fridus, Stephanie R.; Rodman, Orlando G.; Cyran, Stanley; Cardelli, Marcia B.

doi:10.1001/archderm.1993.01680270115016

Cited by 5 publications

(2 citation statements)

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“…Therapeutic options for granulocytic sarcoma include local surgery, radiation and chemotherapy. The role of systemic chemotherapy is well established in leukemic patients 23,24 . In patients without concurrent leukemia, aggressive combination chemotherapy prolongs life and may prevent the onset of leukemia 25 .…”

Section: Discussionmentioning

confidence: 99%

“…The role of systemic chemotherapy is well established in leukemic patients. 23,24 In patients without concurrent leukemia, aggressive combination chemotherapy prolongs life and may prevent the onset of leukemia. 25 A recent review compared the treatment of 72 cases of non-leukemic granulocytic sarcoma and suggested that most tumors left untreated before leukemic symptoms will almost always progress to acute myelogenous leukemia and that longer diseasefree intervals occur in patients initially treated with systemic therapy (12 months) than those treated with local radiation (6 months) or surgical resection (3 months).…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous granulocytic sarcoma in myelodysplastic syndrome

Câmara¹,

Morais²,

Portugal

et al. 2008

J Cutan Pathol

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Granulocytic sarcoma is an extramedullary tumor of immature cells of granulocytic series, generally associated to acute myelogenous leukemia. The skin is one of the most commonly affected sites. Granulocytic sarcoma can complicate myelodysplastic syndromes and is considered a sign of poor prognosis. They are often misdiagnosed with non-Hodgkin lymphoma of the lymphoblastic type, Burkitt lymphoma and large cell lymphoma. In children, the differential diagnoses also include small, round cell tumors. It is important to diagnose these lesions early because they can precede peripheral blood and bone marrow transformation to acute myelogenous leukemia. We report a case of an elderly patient with myelodysplastic syndrome who developed multiple cutaneous granulocytic sarcoma lesions and discuss prognostic and treatment implications.

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Section: Discussionmentioning

confidence: 99%