Multiple Organ Manifestations in Thromboangiitis Obliterans (Buerger's Disease) A Case Report

Harten, Pontus; Müller-Huelsbeck, Stefan; Regensburger, D.; Loeffler, H

doi:10.1177/000331979604700415

Cited by 33 publications

(19 citation statements)

References 11 publications

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“…On the other hand, documentation based on histological findings of atypical TAO, e.g., that affecting women [11,14], visceral or cerebral blood vessels [11,16,37], a diabetic patient [14] and nonsmokers [11,14] has been increasing. Therefore, there is a question of whether there is room for over-or underdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

Thromboangiitis obliterans: classic and new morphological features

et al. 2000

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The clinical and pathological concept of thromboangiitis obliterans (TAO, Buerger's disease) is still controversial. While the clinical criteria of TAO are relatively well defined, the etiology is unknown and its diagnosis based on pathology is confusing, since there is no consensus on the precise pathological criteria for TAO. To investigate the morphological features that differentiate TAO from arteriosclerosis obliterans (ASO) or thromboembolism, and to clarify the morphological independence of TAO, we studied 94 amputated specimens of lower extremities, including 31 specimens from patients with a clinical diagnosis of TAO and 31 autopsy specimens as control cases. It was revealed that most of the classic morphological features described by Buerger and others are not helpful when considered independently in the differential diagnosis, except for intact internal elastic lamina. In addition, findings of intimal inflammation, intact media and absence of medial calcification were demonstrated to be common in both TAO and thromboembolism. Statistical analysis in the present study, the most comprehensive thus far, showed that novel findings of onion-like-shaped recanalizing vessels in the occluded arteries, adventitial fibrosis without medial fibrosis, swelling of the endothelium of the vasa vasorum and edema beneath the external elastic lamina were characteristic of TAO and would be helpful in a differential diagnosis. When a combination of these morphological features is present, diagnosis of a presumed overlap of TAO and ASO in the same site of the vessel concerned is possible. Furthermore, comparison of statistical evaluations based on morphological features performed in various diagnostic groups implies that the clinical diagnosis of TAO is currently underestimated because the results of the analysis of morphological features of specimens in which TAO was suspected or specimens selected on the basis of a broad and nonspecific definition of TAO were surprisingly similar to the results in strictly defined TAO cases. Our findings suggest that injury and regeneration of minute vessels such as recanalizing vessels and vasa vasorum play a part in the pathogenesis of TAO.

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Section: Introductionmentioning

confidence: 99%

Thromboangiitis obliterans: classic and new morphological features

et al. 2000

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“…[11][12][13][14][15] In addition, TAO typically occurs with an extensive smoking history, though some cases reported symptom onset after only 2 years of tobacco use. [16] The relatively low incidence of TAO in the African American population and the historically higher incidence in males vs. females is of note. [17] While no definitive histological criteria are established, acute phase TAO is associated with inflammatory occlusive thrombi of the afflicted vessel lumen with less extensive inflammation of the vessel wall.…”

Section: Discussionmentioning

confidence: 99%

Elevated lipoprotein(a)-associated accelerated thromboangiitis: A case report

Harris

Gillispie

Solario

et al. 2018

CRIM

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“…It has been reported that, apart from distal arteries and veins [5], visceral vessels [6, 7]and coronary arteries [8]are also occasionally affected in TAO, and involvement of cerebral arteries has been reported in cases in which cerebral artery occlusion led to infarction [9, 10]. The exact etiology of TAO is unknown.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Vein Thrombosis in a Case with Thromboangiitis obliterans

et al. 1999

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Thromboangiitis obliterans is a chronic inflammatory vessel disease that involves predominantly the small and medium-sized arteries and veins of the distal extremities. Appearance and cessation of symptoms are closely related to patterns of tobacco consumption. That cerebral arteries can also be involved is shown by reports of rare cases in which cerebral artery occlusion led to infarction. We report on a 28-year-old man with thromboangiitis obliterans who developed extensive cerebral vein thrombosis after a single episode of cigarette smoking following several years of nonsmoking. Despite extensive evaluation, no other known cause or predisposition of cerebral vein thrombosis could be found. This case suggests that cerebral veins can be involved in thromboangiitis obliterans and patients with thromboangiitis obliterans might be at risk for cerebral vein thrombosis.

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Multiple Organ Manifestations in Thromboangiitis Obliterans (Buerger's Disease) A Case Report

Cited by 33 publications

References 11 publications

Thromboangiitis obliterans: classic and new morphological features

Thromboangiitis obliterans: classic and new morphological features

Elevated lipoprotein(a)-associated accelerated thromboangiitis: A case report

Cerebral Vein Thrombosis in a Case with Thromboangiitis obliterans

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