Cerebral Vein Thrombosis in a Case with Thromboangiitis obliterans

Bischof, Felix; Kuntz, Rainer M.; Melms, Arthur; Fetter, M.

doi:10.1159/000015981

Cited by 11 publications

(7 citation statements)

References 7 publications

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“…In more than 95% of the cases, the lower limbs and predominantly the forefoot are affected [1]. Nevertheless, involvement of visceral vessels [2, 3]and cerebral veins [4]has also been reported. The case presented here is unusual because Raynaud’s phenomenon was the only symptom for many months and arteries of the lower extremities were not affected.…”

Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans:A Rare Cause of a ReversibleRaynaud’s Phenomenon

Noël

Krayenbühl²,

Cerottini³

et al. 2000

Dermatology

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A 25-year-old woman with progressive Raynaud’s phenomenon and digital necrosis is presented. Systemic sclerosis and other connective tissue disorders as well as atherosclerosis and arterial emboli were excluded with appropriate laboratory examinations. Arteriography revealed multiple palmar and digital occlusions with corkscrew-shaped vessels. Based on these characteristic arteriographic and clinical findings, the diagnosis of thromboangiitis obliterans was finally retained. With intravenous perfusion of the prostacyclin analogue iloprost (2 ng/kg/min, 6 h daily during 21 days), a complete healing of Raynaud’s phenomenon and of the digital necrosis was observed. There was no recurrence during the 1-year follow-up. This observation demonstrates that thromboangiitis obliterans is a potential reversible cause of severe Raynaud’s phenomenon in young women even in the absence of lower limb involvement. Early recognition is important to avoid irreversible complications such as loss of digits.

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Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans:A Rare Cause of a ReversibleRaynaud’s Phenomenon

Noël

Krayenbühl²,

Cerottini³

et al. 2000

Dermatology

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“…A TAO oka jelenleg nem ismert, de szoros összefüggést mutat a dohányzással. Ennek abbahagyása a betegség progresszióját nagymér-tékben lassítja, ismételt elkezdése azonban fellángolások-hoz vezethet [4]. A különböző földrajzi régiók és etnikumok között a prevalencia jelentősen különbözik, ez alapján felmerül genetikai háttér lehetősége is [2].…”

Section: Megbeszélésunclassified

“…Az irodalomban szélsőséges esetekről is beszá-molnak. Bischof és mtsai azt találták, hogy hosszabb dohányzásmentes időszak után párórás cigarettázás is kiválthatja a betegség akut fellángolását [4]. Betegünk-ben három és fél éves dohányzásmentes periódus után fél éves dohányzást követően alakult ki az újabb exacerbatio.…”

Section: Megbeszélésunclassified

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Thromboangitis obliterans agyi manifesztációja

Aszalos¹,

Dongó

Farkas

et al. 2016

Orvosi Hetilap

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A thromboangitis obliterans (Buerger-kór) nem atherosclerosisos, a kis-és közepes méretű artériák és vénák szegmentális gyulladásával és thromboticus elzáródásával járó perifériás érbetegség. Etiológiája a mai napig ismeretlen, szoros összefüggést mutat a dohányzással. A tünetek 45 éves kor előtt kezdődnek, jellegzetes a hullámzó kórlefolyás. A végtagok acralis részein akut és krónikus ischaemiás vagy infektív tünetek alakulnak ki. A Buerger-kór diagnózisa elsősorban a klinikai képen és az angiográfiás vizsgálaton alapul, de alapvetően fontos autoimmun betegség, thrombophilia, diabetes mellitus és proximalis emboliaforrás kizárása is. A betegség leggyakrabban a végtagok ereit érinti, ritkán azonban érintettek lehetnek az agyi, a coronaria-és a zsigeri artériák is. A szerzők 49 éves, korábban már Buerger-kór miatt kezelt férfi kórtörténetéről számolnak be, akinél akut ischaemiás stroke-ot diagnosztizáltak. Kép-alkotó vizsgálatokkal akut és krónikus ischaemiás laesiókat, valamint a tünetképző oldalon az arteria cerebri media nem atheroscleroticus arteriopathiáját igazolták. A részletes kivizsgálás során más etiológiát nem találtak. Orv. Hetil., 2016, 157(30), 1207-1211. Kulcsszavak: thromboangitis obliterans, dohányzás, ischaemiás stroke Cerebral manifestations of thromboangiitis obliterans Case reportThromboangiits obliterans (Buerger's disease) is a non-atherosclerotic, segmental inflammatory and obliterative disease affecting small and medium sized arteries and veins. The etiology is still unknown, but it is in close relationship with tobacco use. Symptoms begin under the age of 45 years and the undulating course is typical. Patients usually present with acute and chronic ischemic or infectious acral lesions. Diagnosis is usually based on clinical and angiographic criteria and it is important to exclude autoimmune disease, thrombophilia, diabetes, and proximal embolic sources. Even though Buerger's disease most commonly involves the arteries of the extremities, the pathologic findings sometimes affect the cerebral, coronary and internal thoracic, renal and mesenteric arteries as well. The authors present the history of a patient with known Buerger's disease and acute ischemic stroke. Brain imaging detected acute and chronic ischemic lesions caused by middle cerebral non-atherosclerotic arteriopathy on the symptomatic side. Other etiology was excluded by detailed investigations.

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“…Nevertheless, the etiology of about 20% of CVT cases remains open [1]. Dural sinus thrombosis as a complication of vasculitis is a wellknown neurologic complication of Behc¸et disease [2] but has also been described in systemic lupus erythematosus, WegenerÕs granulomatosis, and single cases of thrombangiitis obliterans [3][4][5][6][7][8][9][10][11][12]. We report the case of a young woman with an unclassifiable vasculitis involving the dural sinuses and the large extracranial brain-supplying arteries.…”

Section: Introductionmentioning

confidence: 99%

An unusual form of vasculitis involving the dural sinuses and extracranial arteries — A case report

et al. 2011

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Cerebral venous thrombosis (CVT) associated with vasculitis has been described only in the context of small vessel angiitis so far. We report on a 30-year-old woman who developed CVT which was followed by progressive occlusion of large extracranial arteries. Cerebrospinal fluid (CSF) showed evidence for inflammation with pleocytosis and positive oligoclonal bands. Angiography revealed no abnormalities of the aortic arch, but three remaining criteria for Takayasu arteritis were fulfilled. Antiphospholipid antibodies were elevated or within borderline values, possibly indicating the beginning of lupus erythematosus. Because of additional protein S deficiency and increased factor VIII activity, the patient was orally anticoagulated. Immunosuppressive therapy was started with azathioprine. This was followed by a normalization of cell count in CSF. Immunosuppression was changed to methotrexate after acute progression of the occlusive disease. As far as we know this is the first case report with a combination of sinus thrombosis and large vessel arteritis.

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Cerebral Vein Thrombosis in a Case with Thromboangiitis obliterans

Cited by 11 publications

References 7 publications

Thromboangiitis obliterans:A Rare Cause of a ReversibleRaynaud’s Phenomenon

Thromboangiitis obliterans:A Rare Cause of a ReversibleRaynaud’s Phenomenon

Thromboangitis obliterans agyi manifesztációja

An unusual form of vasculitis involving the dural sinuses and extracranial arteries — A case report

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