Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China

Li, Daochuan; Zhang, Rong; Cui, Lianhua; Chu, Chen; Zhang, Haiyan; Sun, Hao; Luo, Jing; Zhou, Lixiao; Chen, Liping; Cui, Jian; Shen, Chen; Mai, Bi-Xian; Chen, She-Jun; Yu, Jianzhen; Cai, Zongwei; Zhang, Jianqing; Jiang, Yousheng; Aschner, Michael; Chen, Rui; Zheng, Yuxin; Chen, Wen

doi:10.1016/j.envpol.2019.02.097

Cited by 123 publications

(83 citation statements)

References 63 publications

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“…Based on transcriptome data, we reveal that the changes in the pathways induced by CR diet are tissue speci c. CR mainly inhibited the in ammatory related pathways in lung but activated the pathways of xenobiotic metabolism in liver. The variety in pathway regulations were consistent with the biological functions and the response to PM exposure [8]. However, compatible pathway regulations could be shared by lung and liver of CR-fed mice, such as LXR/RXR, nicotine degradation pathways of xenobiotic metabolism.…”

Section: Discussionsupporting

confidence: 64%

“…Bronchoalveolar lavage uid (BALF) was collected as described previously [8]. The cells and supernatant were separated by centrifugation of BALF at 400×g for 7 min at 4 ℃.…”

Section: Balf Analysismentioning

confidence: 99%

“…Previously, we established a real-world ambient PM exposure system and showed that high level of PM exposure causes multiple-organ damage in mice [8]. The system we constructed offers optimized conditions to minimize distress and discomfort during the inhalation exposure and replicates a realambient PM exposure scenario for experimental animals, resembling the natural state of human exposure to the extent possible.…”

Section: Introductionmentioning

confidence: 99%

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Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Chen

et al. 2020

Preprint

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Background: Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanisms have yet to be defined.Results: Male C57BL/6J mice were fed with a CR diet or ad libitum (AL) and exposed to PM for 4 weeks in a real-ambient PM exposure system located at Shijiazhuang, China, with a daily mean concentration (95.77 μg/m³) of PM2.5. Compared to AL-fed mice, CR-fed mice showed attenuated PM-induced pulmonary injury and extra-pulmonary toxicity characterized by reduction in oxidative stress, DNA damage and inflammation. RNA sequence analysis revealed that several pulmonary pathways that were involved in production of reactive oxygen species (ROS), cytokine production, and inflammatory cell activation were inactivated, while those mediating antioxidant generation and DNA repair were activated in CR-fed mice upon PM exposure. In addition, transcriptome analysis of murine livers revealed that CR led to induction of xenobiotic metabolism and detoxification pathways, corroborated by increased levels of urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and decreased cytotoxicity measured in an ex vivo assay.Conclusion: These novel results demonstrate, for the first time, that CR in mice confers resistance against pulmonary injuries and extra-pulmonary toxicity induced by PM exposure. CR led to activation of xenobiotic metabolism and enhanced detoxification of PM-bound chemicals. These findings provide evidence that dietary intervention may afford therapeutic means to reduce the health risk associated with PM exposure.

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Section: Discussionsupporting

confidence: 64%

“…Bronchoalveolar lavage uid (BALF) was collected as described previously [8]. The cells and supernatant were separated by centrifugation of BALF at 400×g for 7 min at 4 ℃.…”

Section: Balf Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Chen

et al. 2020

Preprint

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“…The IVC exposure method was as described in Li et al (2019). Briefly, a unique system was built with both exposure and control chambers.…”

Section: Ivc Exposurementioning

confidence: 99%

“…The size and composition of the PM particles were reported in our previous study (Li et al, 2019). Briefly, during the 11weeks PM exposure in Shijiazhuang, 2017, the PM concentration were constantly monitored in the ambient air of the study site as well as inside the chambers.…”

Section: Pm Composition and Exposure Dosementioning

confidence: 99%

Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice

Cui

Shi

et al. 2020

Front. Pharmacol.

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The impact of PM2.5 on kidney

Zhang

Huang

et al. 2022

J of Applied Toxicology

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PM2.5 poses a severe risk to kidneys, inducing kidney function decline, increasing the risk of suffering from chronic kidney diseases and promoting the occurrence and development of various renal tumors. The mechanism of PM2.5‐induced renal injury may involve oxidative stress, inflammatory response, and cytotoxicity. This paper elaborated PM2.5‐induced kidney damage and the corresponding possible mechanism so as to raise awareness of air pollution and reduce the damage to human body.

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Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China

Cited by 123 publications

References 63 publications

Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice

The impact of PM2.5 on kidney

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