Multiple organ failure and coma as initial presentation of pheochromocytoma in a patient with multiple endocrine neoplasia (MEN) type II A

W, Lorz; Cottier, Chr; Imhof, E; N, Gyr

doi:10.1007/bf01694777

Cited by 8 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the appropriate timing of surgery remains unclear. As shown in Table 1 , surgery on the day following admission may not be associated with outcome [ 2 , 10 , 11 ]. In addition, other vital signs and clinicopathological features do not appear to be associated with outcome [ 2 , 5 , 6 , 9 – 14 ].…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma multisystem crisis treated with emergency surgery: a case report and literature review

et al. 2015

View full text Add to dashboard Cite

BackgroundPheochromocytoma is a neuroendocrine tumor that predominantly presents with hypertension, palpitations, and tachycardia due to excessive catecholamine excretion. Although pheochromocytoma multisystem crisis (PMC) is relatively rare, urologists and clinicians should focus on early diagnosis as delay in initiating the appropriate treatment can lead to mortalityCase presentationA 70-year-old man developed ileus after a few days of medication for hypertension. Computed tomography incidentally revealed a left adrenal mass. This finding together with his clinical course was compatible with pheochromocytoma. An α-blocker was administered immediately, and his blood pressure was well controlled. However, his general condition and laboratory data deteriorated rapidly, and the patient was diagnosed with PMC with lethal status. Thus, emergency adrenalectomy was performed without confirmation of catecholamine levels. From the resected specimen, his tumor was judged as pheochromocytoma. On immunohistochemical analysis, the proliferation index evaluated by Ki-67 staining was 9.7 %. This case report was approved by the Human Ethics Review Committee of the Nagasaki University Hospital.ConclusionThe present case of PMC was successfully treated with emergency surgery. The benign pheochromocytoma also presented with high cell proliferation potential, which may be a cause of the extreme aggressiveness of PMC.

show abstract

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma multisystem crisis treated with emergency surgery: a case report and literature review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Phaeochromocytoma is a tumour of extremely variable symptomatology and can imitate various illnesses: angina pectoris, myocardial infarction, ruptured aortic aneurysm, hyperthyroidism, epilepsy, eclampsia, orthostatic hypotension, shock, multiple organ failure and acute abdomen [1, 2, 3, 4, 13, 14]. The tumour in our patient manifested itself in an attack of dyspnoea resulting from pulmonary oedema.…”

Section: Discussionmentioning

confidence: 99%

“…The extremely high peripheral vascular resistance measured using the Swan-Ganz catheter led to the consideration of a (nor)adrenergic crisis. The differential diagnosis of patients with acute dyspnoea should include phaeochromocytoma as well as primary cardiopulmonary conditions [8, 13, 15]. This is particularly so when there is a family history of phaeochromocytoma, MEN [5, 16, 17], von Hippel-Lindau disease [5, 17, 18]or neurofibromatosis type 1 (von Recklinghausen).…”

Section: Discussionmentioning

confidence: 99%

Acute Dyspnoea Resulting from Pulmonary Oedema as the First Sign of a Phaeochromocytoma

Iperen

Giezen²,

Krämer³

et al. 2001

Respiration

View full text Add to dashboard Cite

The day after undergoing neck dissection, a 42-year-old woman developed acute dyspnoea due to pulmonary oedema. Measurements with a Swan-Ganz catheter revealed not only cardiac depression but also a greatly increased peripheral vascular resistance: 5,400 dyn·s· cm^–5/m². A phaeochromocytoma with acute cardiac failure leading to pulmonary oedema was considered. Treatment with α- and β-blockers was complicated by severe hypotension and later ventricular fibrillation. Mechanical ventilation was required for 6 days following resuscitation. Investigation of the urine subsequently showed greatly increased catecholamine concentrations, while imaging revealed bilateral adrenal tumours. Our case history shows that acute pulmonary oedema may be the presenting manifestation of a phaeochromocytoma. The pulmonary oedema resulted partly from backward failure following tachycardia, myocyte necrosis and the greatly increased peripheral vascular resistance, and partly from increased permeability of the capillary network in the lungs.

show abstract

Clinical characteristics and outcomes of pheochromocytoma crisis: a literature review of 200 cases

Ando

Ono

Sano

et al. 2022

J Endocrinol Invest

View full text Add to dashboard Cite

Multiple organ failure and coma as initial presentation of pheochromocytoma in a patient with multiple endocrine neoplasia (MEN) type II A

Cited by 8 publications

References 10 publications

Pheochromocytoma multisystem crisis treated with emergency surgery: a case report and literature review

Pheochromocytoma multisystem crisis treated with emergency surgery: a case report and literature review

Acute Dyspnoea Resulting from Pulmonary Oedema as the First Sign of a Phaeochromocytoma

Clinical characteristics and outcomes of pheochromocytoma crisis: a literature review of 200 cases

Contact Info

Product

Resources

About