Multiple neck papules in a child with acute lymphocytic leukemia. Multiple basal cell carcinomas (BCCs)

Basal cell carcinoma in childhood: Case report and literature review

“…Childhood onset of BCC has previously been associated with albinism, 21,27 Bazex syndrome, 21,28 BCC nevus syndrome, 25,26,[29][30][31][32][33]53 nevus sebaceous, 2,25,26,[34][35][36][37][38][39][40] solid organ transplants, 47,48 xeroderma pigmentosum, 25,29,32,[49][50][51][52] and radiotherapy-treated cancers, such as astrocytoma, 44 ependymoma, 41 hemangioma, 26 Hodgkin lymphoma, 38,46 leukemia, 38,[42][43][44][45][46] medulloblastoma, 22,29,33,46 neuroblastoma, 38 optic nerve glioma, 41 and unspecified malignant tumor. 32 Children are defined to be 18 y...…”

Multiple synchronous pigmented basal cell carcinomas following radiotherapy for Hodgkin's disease

“…Furthermore, Potaznik reported one case of Hodgkin’s disease in a patient with NBCCS 12 . This genodermatosis follows an autosomal dominant mode of inheritance with 97% penetrance 13 but the genetic defect alone is not able to cause the BCCs: a minimum of two mutational events must occurr (a germinal and then a somatic mutation or two somatic mutations) 14 . The second mutation may be caused by ionizing radiation and may have occurred in our patient on the occasion of the previous radiotherapy.…”