1991
DOI: 10.1002/mpo.2950190612
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Basal cell carcinoma in young patients after irradiation for childhood malignancy

Abstract: Three patients underwent cranial irradiation as part of treatment for childhood malignancy. Two of these patients had acute lymphocytic leukemia and one had an astrocytoma. All had longlasting remissions from their childhood malignancy but 8-15 years later developed a basal cell carcinoma of the scalp within previous radiation portals. The basal cell carcinomas were all treated successfully using Mohs micrographic surgery. Follow-up of patients receiving irradiation for childhood malignancy should include peri… Show more

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Cited by 32 publications
(19 citation statements)
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References 6 publications
(6 reference statements)
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“…Our finding of early onset of BCCs in the radiation fields (mean latency period 5 yr. after exposure to radiation) was also reported by these authors. Dinehart et al [1991] reported 3 young patients (2 with acute lymphoblastic leukemia, and 1 with astrocytoma) who developed a BCC of the scalp 8-15 years after irradiation. The multiple meningiomas we observed in one individual (latency period 22 yr.) and the cerebellar ependymoma in another (latency period 2 yr.) was likely related to the radiation therapy for medulloblastoma.…”
Section: Discussionmentioning
confidence: 99%
“…Our finding of early onset of BCCs in the radiation fields (mean latency period 5 yr. after exposure to radiation) was also reported by these authors. Dinehart et al [1991] reported 3 young patients (2 with acute lymphoblastic leukemia, and 1 with astrocytoma) who developed a BCC of the scalp 8-15 years after irradiation. The multiple meningiomas we observed in one individual (latency period 22 yr.) and the cerebellar ependymoma in another (latency period 2 yr.) was likely related to the radiation therapy for medulloblastoma.…”
Section: Discussionmentioning
confidence: 99%
“…9 Whether radiotherapy enhances risk of squamous cell carcinoma (SCC) is less clear. A population-based study among men in Alberta, Canada, reported a 5-to 6-fold increase in incidence of BCC and SCC associated with nondiagnostic x-ray exposure.…”
Section: Discussionmentioning
confidence: 99%
“…2,[5][6][7] In conclusion, radiated skin areas should be explored as part of the long-term follow-up in children who have received radiotherapy for internal malignancies. This follow-up should probably be maintained for life.…”
Section: Marín-gutzke Et Almentioning
confidence: 99%
“…4 In the literature, we know of just 6 cases published of children in whom basal cell carcinoma developed at an early age after radiotherapy. [5][6][7] We describe 2 patients who received ionizing radiation as part of a curative regimen for childhood malignancy and later developed basal cell carcinoma at an early age.…”
mentioning
confidence: 99%