Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review

Hu, Haiyi; Huang, Dayong; Ji, Ming; Zhang, Shutian

doi:10.1016/j.ajg.2020.01.002

Cited by 11 publications

(16 citation statements)

References 19 publications

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“…Noncardial clinical symptoms include generalized fatigue, purpura, sensorimotor polyneuropathy, carpal tunnel syndrome and lumbar spinal stenosis [ 1 ]. A growing body of evidence has highlighted a link between amyloidosis and MM, and an estimated rate of 10–15% of amyloidosis patients might develop MM [ 3 , 8 ]. The current therapeutic criteria for amyloidosis are based on the precursor-product concept.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…A wide variety of treatments is available based on amyloidosis type. Concerning the MM, hematopoietic stem cell transplantation plays a pivotal role in the management [ 8 ]. Potential candidates to autologous stem-cell transplantation are treated initially with two to four cycles of nonmelphalan containing induction therapy [ 9 ].…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Cardiac amyloidosis with overt multiple myeloma presenting with pulmonary effusion: case report

Saad¹,

Moussa

M.D.

et al. 2021

Journal of Surgical Case Reports

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Amyloidosis was initially described by Nicolaes Fonteyn in 1639. It is caused by the deposition of soluble immunoglobulin light chains as insoluble fibrils and can affect any organ including the heart, nervous system, dermis and subcutaneous tissue, kidneys and liver. This is a rare case of cardiac amyloidosis occurring with multiple myeloma and pleural effusion. A 65-year-old Arab woman, nonsmoker, nonalcoholic, known to have hypothyroidism and multiple myeloma, presented to the hospital with dyspnea and basilar crackles. Workup was done to exclude leukemia. Cardiac echography showed features of amyloidosis. Cardiac amyloidosis occurring with multiple myeloma and pleural effusion is rare. However, it is stated that 10–15% of amyloidosis patients might develop multiple myeloma (MM).

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Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Cardiac amyloidosis with overt multiple myeloma presenting with pulmonary effusion: case report

Saad¹,

Moussa

M.D.

et al. 2021

Journal of Surgical Case Reports

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“…When the patient is asymptomatic, it is called smoldering MM (SMM). Approximately 10%-15% of MM patients develop overt AL[ 4 ]. However, there are few reports of MM coexisting with gastrointestinal AL[ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 10%-15% of MM patients develop overt AL[ 4 ]. However, there are few reports of MM coexisting with gastrointestinal AL[ 4 ]. Moreover, there are only two reported cases of SMM combined with gastrointestinal AL to date[ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal amyloidosis in a patient with smoldering multiple myeloma: A case report

Liu¹,

Ding²,

Liu³

et al. 2022

WJCC

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BACKGROUND Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell proliferative disorder that can progress to multiple myeloma (MM). Amyloidosis (light chain) (AL) is the most common form of systemic amyloidosis. There are few reports of SMM coexisting with AL involving the digestive tract. CASE SUMMARY A 63-year-old woman presented with lower limb edema, abdominal distension, abdominal pain, and hematochezia. Gastroscopy showed gastric retention, gastric angler mucosal coarseness, hyperemia, and mild oozing of blood. Colonoscopy showed hyperemic and edematous mucosa of the distal ascending colon and sigmoid colon with the presence of multiple round and irregular ulcers, submucosal ecchymosis, and hematoma. Gastric and colonic tissue biopsy confirmed the diagnosis of AL by positive Congo red staining. MM was confirmed by bone marrow biopsy and immunohistochemistry. The patient had no hypercalcemia, renal dysfunction, anemia, bone lesions or biomarkers of malignancy defined as plasma cells > 60% in bone marrow. Additionally, no elevated serum free light chain ratio, or presence of bone marrow lesions by magnetic resonance imaging (SLiM criteria) were detected. The patient was finally diagnosed with SMM coexisting with AL. She received chemotherapy and was discharged when the symptoms were relieved. She is doing well at nearly five years of follow up. CONCLUSION This case highlights that high index of suspicion is required to diagnose gastrointestinal AL. It should be suspected in elderly patients with endoscopic findings of granular-appearing mucosa, ecchymosis, and submucosal hematoma. Timely diagnosis and appropriate therapy can help to improve the prognosis of these patients.

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“…Traditionally, MM has been estimated to be present in approximately 10–20% of AL patients [ 2 , 4 ]. The symptoms and signs of AL in patients with MM are different according to organs involved [4] .…”

Section: Introductionmentioning

confidence: 99%

Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Hamdaoui

Natiq

Benlarroubia

et al. 2020

Leukemia Research Reports

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Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma. This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.

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Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review

Cited by 11 publications

References 19 publications

Cardiac amyloidosis with overt multiple myeloma presenting with pulmonary effusion: case report

Cardiac amyloidosis with overt multiple myeloma presenting with pulmonary effusion: case report

Gastrointestinal amyloidosis in a patient with smoldering multiple myeloma: A case report

Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

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