Multiple myeloma with hypogammaglobulinemia.Electron microscopic and chromosome studies

Guillan, Ramon A.; Ranjini, R.; Zelman, Samuel; Hocker, E. Virginia; Smalley, Robert L.

doi:10.1002/1097-0142(197005)25:5<1187::aid-cncr2820250526>3.0.co;2-z

Cited by 11 publications

(1 citation statement)

References 10 publications

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“…The ultrastructural appearances in our patient favour the latter hypothesis, as the cells show features well within the range encountered in secretory disease (Maldonado et al, 1966;Fisher & Zawadzki, 1970), and do not support the suggestion that decreased cellular differentiation accounts for the non-secretory phenomenon (Hobbs, 1969;Graham & Bernier, 1975). In contrast, however, some other cases have shown features suggesting an impaired capacity for protein synthesis (Guillan et al, 1970;Gach et al, 1971;Mancilla & Davis, 1977).…”

Section: Discussionmentioning

confidence: 99%

Non‐excretory Multiple Myeloma

et al. 1979

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The clinical and laboratory features in five patients with non-excretory myeloma are described including plasma cell immunofluorescence and, in two cases, ultrastructure. Findings are compared with those in similar patients previously reported, and those in excretory disease. Clinical, haematological and biochemical features were similar to those found in excretory myeloma, showing differences only in relation to the absence of serum or urinary monoclonal immunoglobin. Cellular cytological and ultrastructural features allowed no differentiation from excretory cells. Within this non-excretory group distinction between secretory and non-secretory myeloma cells is possible on the basis of immunofluorescence. Differing patterns of intermittent excretion occurred in three of these patients.

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Section: Discussionmentioning

confidence: 99%

Non‐excretory Multiple Myeloma

et al. 1979

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Nonsecretory myeloma.Immunofluorescent demonstration of paraprotein within bone marrow plasma cells

Arend

Adamson

1974

Cancer

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A patient with multiple myeloma is reported with hypogammaglobulinemia and the absence of a paraprotein in the serum, and absence of Bence Jones protein in the urine. The clinical course was malignant with massive plasma cell infiltration of the liver and kidneys contributing to insufficiency of each organ. Immunofluorescent studies on bone marrow smears demonstrated bright staining for kappa and weak staining for gamma antigenic determinants within the cytoplasm of the plasma cells. It is suggested that the aberrant intracellular proteins were unable to be combined into a full immunoglobulin molecule or that a defect was present in the secretory pathway.

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Nonsecretory multiple myeloma

Rubio-Félix

Giralt

Giraldo

et al. 1987

Cancer

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Among 186 patients with multiple myeloma (MM), five women were diagnosed as having MM without M-component in serum and or urine at the diagnosis and along the evolution. Bone marrow plasmacytosis at greater than 30% was found in all patients and bone x-rays showed lytic lesions in all but one case, osteoporosis in all, and pathologic fractures in two. Serum electrophoresis showed a striking hypogammaglobulinemia in all, and polyclonal immunoglobulin levels were markedly reduced. The immunofluorescence of plasma cells in bone marrow was positive for monoclonal light chain polypeptides in four patients, and the ultrastructure showed mature plasmocytes with a wide rough endoplasmic reticulum (RER) and an intact Golgi apparatus. In three patients, therapy with melphalan plus prednisone was started. The remaining two were treated with an M-2 protocol. Death was an early event in two patients; the response was good in the remaining patients, without differences regarding secretory MM. Despite some reports stressing an unfavourable prognosis in MM without M-component, in our series it is roughly the same as in MM with secretion.

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Multiple myeloma with hypogammaglobulinemia.Electron microscopic and chromosome studies

Cited by 11 publications

References 10 publications

Non‐excretory Multiple Myeloma

Non‐excretory Multiple Myeloma

Nonsecretory myeloma.Immunofluorescent demonstration of paraprotein within bone marrow plasma cells

Nonsecretory multiple myeloma

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