Nonsecretory myeloma.Immunofluorescent demonstration of paraprotein within bone marrow plasma cells

Arend, William P.; Adamson, John W.

doi:10.1002/1097-0142(197403)33:3<721::aid-cncr2820330317>3.0.co;2-d

Cited by 29 publications

(4 citation statements)

References 15 publications

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“…Clinical, radiological and haematological features in non-excretory disease do not appear to differ significantly from those in excretory disease. Elevated ESR levels may have more significance in non-excretory disease, reflecting coexistence of complications and indicating a poor prognosis (Arend & Adamson, 1974;Fabia et al, 1974). Uraemia, as in our cases, is almost always associated with hypercalcaemia and is usually reversible with correction of the hypercalcaemia (Prost et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

Non‐excretory Multiple Myeloma

et al. 1979

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The clinical and laboratory features in five patients with non-excretory myeloma are described including plasma cell immunofluorescence and, in two cases, ultrastructure. Findings are compared with those in similar patients previously reported, and those in excretory disease. Clinical, haematological and biochemical features were similar to those found in excretory myeloma, showing differences only in relation to the absence of serum or urinary monoclonal immunoglobin. Cellular cytological and ultrastructural features allowed no differentiation from excretory cells. Within this non-excretory group distinction between secretory and non-secretory myeloma cells is possible on the basis of immunofluorescence. Differing patterns of intermittent excretion occurred in three of these patients.

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Section: Discussionmentioning

confidence: 99%

Non‐excretory Multiple Myeloma

et al. 1979

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“…Although some of these immunofluorescence studies suggest the presence of free immunoglobulin chains within the cell, they do not, as pointed out by Arend and Adamson (1974), constitute unequivocal evidence for this.…”

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confidence: 90%

Intact and fragmented intracellular immunoglobulin in a case of non-secretory myeloma.

Whicher¹,

Davies²,

Grayburn³

1975

J Clin Pathol

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“…Conflicting reports exist regarding the natural history of non-secretory myeloma, indicating both a more and a less favourable prognosis (12, IS). Im-munofluorescence and immunoperoxidase studies of intracellular immunogloblslins in myeloma cells suggest that patients with non-secretory myeloma can be subdivided into two categories: those who do not synthesize and those who synthesize but do not secrete monoclonal immunoglobulin (2,3,5,6,9,18,20,21,22,23,25,26,28,29,31,34).…”

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Non‐Secretory or Low‐Secretory Myeloma with Intracellular Kappa Chains

Turesson

Grubb

1978

Journal of Internal Medicine

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ABSTRACT. This report concerns six cases of multiple myeloma characterized by either no demonstrable monoclonal immunoglobulin in plasma or urine or by trace amounts (≤0.1 g/***1) of monoclonal kappa chains in the urine. In all cases there was an infiltration of the bone marrow by plasma cells containing kappa chains but no heavy chains. A retrospective analysis was made of 126 consecutive cases of Bence Jones myeloma. The number of kappa and lambda cases was approximately the same. AH cases secreting ≤0.1 g light chains per 1 urine were of kappa type. This contrasts with a kappa/lambda ratio of 1.4‐1.9 among reported series of M‐components containing both heavy and light chains. A review of reported cases of non‐secretory myeloma revealed a preserved capacity for Ig synthesis in the majority of cases and among these a preponderance of kappa chain producing clones. These observations might be explained by a higher tendency for kappa chain producing cells to mutate to low secretors or to cells producing abnormal light chains which are catabolized rapidly. The clinical data from our patients do not indicate a more pessimistic prognosis in non‐ or low‐secretory myeloma, than in other cases of multiple myeloma.

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Nonsecretory myeloma.Immunofluorescent demonstration of paraprotein within bone marrow plasma cells

Cited by 29 publications

References 15 publications

Non‐excretory Multiple Myeloma

Non‐excretory Multiple Myeloma

Intact and fragmented intracellular immunoglobulin in a case of non-secretory myeloma.

Non‐Secretory or Low‐Secretory Myeloma with Intracellular Kappa Chains

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