Multiple myeloma presenting with focal segmental glomerulosclerosis

Valizadeh, Narges; Makhdoomi, Khadijeh; Noroozinia, Farahnaz; Behzadi, Farhad

doi:10.4103/2278-330x.114146

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…Valizadeh et al ( 10 ) reported the case of a patient who had been pathological diagnosed with FSGS and was confirmed with MM upon follow-up. The study speculated that MM may be a rare secondary occurrence to FSGS.…”

Section: Discussionmentioning

confidence: 97%

“…Thus, from the pathophysiological perspective, the renal pathology of patients may indeed demonstrate FSGS. However, the study by Valizadeh et al ( 10 ) did not repeat the renal biopsy following the patient's MM diagnosis and did not perform Congo red staining or light chain immunological testing on the original pathological sections. Therefore, the pathological changes in the kidney could not be confirmed following the MM diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, following a retrospective review of FSGS and MM English-language studies, nine publications were identified. Of these studies, seven demonstrated an association between FSGS and plasma cell proliferative disorders ( 2 , 5 – 10 ). However, the other two studies indicated little or no correlation between the two conditions ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Dong¹,

Xing²,

Wang³

et al. 2015

Oncology Letters

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The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end-stage renal disease.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Dong¹,

Xing²,

Wang³

et al. 2015

Oncology Letters

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“…To the best of our knowledge, only 9 cases of FSGS with MM have been reported in the English language literature [ 4 , 5 , 16 , 17 , 19 , 20 ]. The average time between diagnosis of MM and FSGS was about 6–18 months [ 9 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma in a Patient with Focal Segmental Glomerulosclerosis: A Case Report

et al. 2018

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Patient: Male, 48Final Diagnosis: Multiple myelomaSymptoms: Back painMedication: —Clinical Procedure: —Specialty: HematologyObjective:Rare diseaseBackground:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome in adults, which can be primary, or secondary to various causes. Unlike membranous nephropathy, FSGS is less likely to be associated with malignancy. Few cases have been reported of the occurrence of FSGS with hematological malignancies like multiple myeloma (MM).Case Report:A 48-year-old man presented with nephrotic syndrome and renal impairment and was diagnosed with primary FSGS after kidney biopsy, which showed a segmental scar with diffuse effacement of foot processes on electron microscopy. Treatment with steroids reduced proteinuria and stabilized the renal function. A few months later, the patient presented with acute Kidney Injury, bone pain, and anemia. A diagnosis of MM was made based on the bone marrow biopsy. Treatment of MM decreased proteinuria and improved renal function.Conclusions:There is an association between FSGS and MM through an unclear mechanism.

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Multiple myeloma presenting with focal segmental glomerulosclerosis

Cited by 2 publications

References 5 publications

Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Multiple Myeloma in a Patient with Focal Segmental Glomerulosclerosis: A Case Report

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