Isocyanide Chemistry 2012
DOI: 10.1002/9783527652532.ch7
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Multiple Multicomponent Reactions with Isocyanides

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Cited by 23 publications
(13 citation statements)
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“…32 Recently, the use of the P-3CR and the U-4CR in polymer chemistry was demonstrated by our [34][35][36][37][38][39] and other groups. [40][41][42][43] Furthermore, sequential Ugi reactions were studied by Wessjohann et al for the synthesis of peptide-peptoid 60 chimeras 31,44,45 and in the synthesis of macrocycles. 31,46 The Passerini reaction is a one-pot reaction of a carboxylic acid with an oxo component (aldehyde or ketone) and an isocyanide, leading to α-acyloxy carboxamides, 47 whereas in the U-4CR, the fourth component is an amine and the obtained products are 65 α-aminoacylamides ( Figure 1).…”
mentioning
confidence: 99%
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“…32 Recently, the use of the P-3CR and the U-4CR in polymer chemistry was demonstrated by our [34][35][36][37][38][39] and other groups. [40][41][42][43] Furthermore, sequential Ugi reactions were studied by Wessjohann et al for the synthesis of peptide-peptoid 60 chimeras 31,44,45 and in the synthesis of macrocycles. 31,46 The Passerini reaction is a one-pot reaction of a carboxylic acid with an oxo component (aldehyde or ketone) and an isocyanide, leading to α-acyloxy carboxamides, 47 whereas in the U-4CR, the fourth component is an amine and the obtained products are 65 α-aminoacylamides ( Figure 1).…”
mentioning
confidence: 99%
“…[40][41][42][43] Furthermore, sequential Ugi reactions were studied by Wessjohann et al for the synthesis of peptide-peptoid 60 chimeras 31,44,45 and in the synthesis of macrocycles. 31,46 The Passerini reaction is a one-pot reaction of a carboxylic acid with an oxo component (aldehyde or ketone) and an isocyanide, leading to α-acyloxy carboxamides, 47 whereas in the U-4CR, the fourth component is an amine and the obtained products are 65 α-aminoacylamides ( Figure 1). 28 Compared to the P-3CR, the U-4CR thus offers the possibility to introduce two different side chains in one single reaction step.…”
mentioning
confidence: 99%
“…With respect to 4: The well-planned combination of MCRs (unions) [ 170 , 182 , 183 , 184 , 185 ] opens up a further method for reducing the number of synthesis steps with simultaneous structural assembly based on a modular building concept, such as Scheme 18 .…”
Section: Multicomponent Chemistry—the Futurementioning
confidence: 99%
“…With respect to 4: The well-planned combination of MCRs (unions) [172,[186][187][188][189] opens up a further method for reducing the number of synthesis steps with simultaneous structural assembly based on a modular building concept, such as Scheme 18.…”
mentioning
confidence: 99%