Multiple molecular targets in cancer chemoprevention by curcumin

Thangapazham, Rajesh L.; Sharma, Anuj; Maheshwari, Radha K.

doi:10.1208/aapsj080352

Cited by 266 publications

(168 citation statements)

References 70 publications

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“…For instance, curcumin, the active constituent of turmeric 281 (Curcuma longa), a root vegetable, has been shown to be beneficial in all 282 three stages of carcinogenesis (Thangapazham et al 2006 …”

Section: Hydroxy Cinnamic Acids (Hca) 252mentioning

confidence: 99%

Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.)

Taleb

Maddocks

Morris

et al. 2016

Journal of Ethnopharmacology

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Section: Hydroxy Cinnamic Acids (Hca) 252mentioning

confidence: 99%

Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.)

Taleb

Maddocks

Morris

et al. 2016

Journal of Ethnopharmacology

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“…With anti-inflammatory, anti-oxidative, and anti-carcinogenic properties by targeting various molecules such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), CUR has been extensively used as a food preservative in India (18)(19)(20). Now, it is showing promising results in clinical trials as a potential therapy for inflammatory and malignant diseases (21,22).…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits the AKT/NF-κB Signaling via CpG Demethylation of the Promoter and Restoration of NEP in the N2a Cell Line

Deng

Wang

et al. 2014

AAPS J

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Abstract. Curcumin (CUR), a non-toxic polyphenol from Curcuma longa, has been investigated as a potential therapy with anti-inflammatory and anti-oxidative effects for Alzheimer's disease (AD), which depicts features of chronic inflammatory environment resulting in cellular death. However, it remains largely unknown whether the anti-inflammatory effect of CUR in AD is associated with its property of CpG demethylation, which is another function of CUR with the most research interest during recent years. Neprilysin (NEP, EP24.11), a zinc-dependent metallopeptidase expressed relatively low in the brain, is emerging as a potent inhibitor of AKT/Protein Kinase B. In addition, hypermethylated promoter of NEP has been reported to be associated with decreases in NEP expression. In the present study, using bisulfite-sequencing PCR (BSP) assay, we showed that the CpG sites in NEP gene were hypermethylated both in wild-type mouse neuroblastoma N2a cells (N2a/wt) and N2a cells stably expressing human Swedish mutant amyloid precursor protein (APP) (N2a/APPswe) associated with familial early onset AD. CUR treatment induced restoration of NEP gene via CpG demethylation. This CUR-mediated upregulation of NEP expression was also concomitant with the inhibition of AKT, subsequent suppression of nuclear transcription factor-κB (NF-κB) and its downstream pro-inflammatory targets including COX-2, iNOS in N2a/APPswe cells. This study represents the first evidence on a link between CpG demethylation effect on NEP and anti-inflammation ability of CUR that may provide a novel mechanistic insight into the anti-inflammatory actions of CUR as well as new basis for using CUR as a therapeutic intervention for AD.

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“…Humans use spices to enhance the flavor of food and mask bitter flavors in medicines (Dignum et al 2001). Because many spices have antibacterial or medicinal properties (Alpers 2009;Liu et al 2007;Thangapazham et al 2006), they are often used in homeopathic treatments. Demand for spices often exceeds their availability from natural sources (Dignum et al 2001), and thus many common cooking spices are also produced synthetically (e.g., vanilla, cinnamon, limonene).…”

Section: Introductionmentioning

confidence: 99%

Analysis of cooking spices in natural waters

Keil

Neibauer

2009

Limnology & Ocean Methods

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An isolation and quantification technique is presented for the analysis of semi-volatile spices and scents in aquatic waters including thymol, eugenol, limonene, carvacrol, vanillin, and cinnamaldehyde. Compounds are isolated from natural waters by solid phase extraction onto Waters Oasis HLB columns and eluted into ethyl acetate. Recovery efficiencies are >70% for most target compounds. Comparison with liquid-liquid extraction and C-18 solid phase extraction indicates that HLB cartridges are more robust and provide equal or better recoveries for target compounds relative to other approaches. Because the compounds are semi-volatile and prone to losses during solvent evaporation, we do not dry the samples completely before quantification by gas chromatography mass spectrometry. Compounds are analyzed using selected ion monitoring with a sensitivity ~1 pg compound per injection. This equates to a sensitivity of about 2-200 ng L -1 in natural waters, or part-per-billion levels. Column loading and matrix effects are minimal and are accounted for by careful monitoring of volumes and by standard additions during GC analysis. Environmental samples (treated sewage, lake, stream, and fjord samples) show a wide range of compounds and quantities, most in the 10-10,000 ng L -1 range. The artificial spice ethylvanillin, which is commonly used as an internal standard in analysis of woody lignin samples, is found in some natural waters. This is likely a result of the industrial-scale production of this compound for culinary and pharmaceutical use.

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Multiple molecular targets in cancer chemoprevention by curcumin

Cited by 266 publications

References 70 publications

Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.)

Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.)

Curcumin Inhibits the AKT/NF-κB Signaling via CpG Demethylation of the Promoter and Restoration of NEP in the N2a Cell Line

Analysis of cooking spices in natural waters

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