Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia

Xu, Yan; Yang, Xue; Wang, Ying; Feng, Dechun; Lin, Shuting; Xu, Lu

doi:10.1016/j.intimp.2009.01.002

Cited by 85 publications

(51 citation statements)

References 37 publications

(44 reference statements)

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“…This suggests Icariin's promising potential in aging-related neurodegenerative disease, since microglia are regarded as macrophage-like cells resident in the CNS and their activation has been implicated in many neurological disorders because of their inflammatory effects [32]. Therapeutic strategies controlling microglial activation and the excessive production of pro-inflammatory factors/molecules may be valuable to control neurodegeneration in dementia [33].…”

Section: Discussionmentioning

confidence: 99%

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis

Zhang

Zug

et al. 2014

PLoS ONE

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Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment of neurodegenerative disorders, including Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. Potential therapeutic effects of Icariin were investigated in an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mouse. Icariin was suspended in carboxymethylcellulose and given orally to APP/PS1 mice. Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment. Following an oral treatment of 10 days, Icariin significantly attenuated Aβ deposition, microglial activation and TGF-β1 immunoreactivity at amyloid plaques in cortex and hippocampus of transgenic mice 5 months of age, and restored impaired nesting ability. Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

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Section: Discussionmentioning

confidence: 99%

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis

Zhang

Zug

et al. 2014

PLoS ONE

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“…The preventative effects of R. rubescens are considered to be as a result of the antibacterial and anti-inflammatory functions of oridonin (11,12). Numerous studies have demonstrated that oridonin possesses antiproliferative and apoptotic activities in various cancer cells, including breast, colorectal and hepatocellular carcinoma cells (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells

Chen

et al. 2017

Oncology Letters

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Abstract.Oridonin is an active constituent isolated from the traditional Chinese herb Rabdosia rubescens, which exerts antitumor effects in experimental and clinical settings. However, its antitumor effects and underlying mechanisms on prostate cancer cells have not yet been clearly identified. In the present study, the androgen-independent prostate cancer PC3 and DU145 cell lines were used as models to investigate the effects and possible mechanisms of oridonin on cellular proliferation and apoptosis. Results demonstrated that oridonin inhibited cellular proliferation, and was able to significantly induce G 2 /M cell cycle arrest and apoptosis. Detailed signaling pathway analysis by western blotting demonstrated that the expression levels of p53 and p21 were upregulated, whereas the expression of cyclin-dependent kinase 1 was downregulated following oridonin treatment, which led to cell cycle arrest in the G 2 /M phase. Oridonin also upregulated the proteolytic cleaved forms of caspase-3, caspase-9 and poly (ADP-ribose) polymerase. Furthermore, the protein expression levels of B-cell lymphoma 2 were decreased and those of Bcl-2-associated X protein were increased following oridonin treatment. In addition, oridonin treatment significantly inhibited the expression of phosphoiniositide-3 kinase (PI3K) p85 subunit and the phosphorylation of Akt. The downstream gene murine double minute 2 was also downregulated, which may contribute to the elevated expression of p53 following oridonin treatment. In conclusion, the results of the present study suggested that oridonin is able to inactivate the PI3K/Akt pathway and activate p53 pathways in prostate cancer cells, resulting in the suppression of proliferation and the induction of caspase-mediated apoptosis.

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“…In the past 40 years a lot of phytochemical researches of RR were focused on the liposoluble diterpenoids of the nonaqueous extracts with anti-tumor, anti-microbial, antiinflammatory, anti-catastrophe, and anti-oxidation actions [1][2][3][4][5][6][7][8][9][10]. Besides, the aqueous extract of RR is believed to be pharmacologic importance [11], and the leaves of RR have been cooked in water and widely drank to treat inflammatory and pain related diseases, such as stomachache, pharyngitis, sore throat and cough [12,13].…”

Section: Introductionmentioning

confidence: 99%

One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30 components of the aqueous extract of Rabdosia rubescens

Tang

Zhao

Wang

et al. 2011

Journal of Chromatography B

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Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia

Cited by 85 publications

References 37 publications

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis

Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells

One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30 components of the aqueous extract of Rabdosia rubescens

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