Multiple metals exposure, elevated blood glucose and dysglycemia among Chinese occupational workers

Yang, Aimin; Liu, Simin; Cheng, Ning; Pu, Hongquan; Dai, Min; Ding, Jiao; Li, Juansheng; Li, Haiyan; Hu, Xiaobin; Ren, Xiaowei; He, Jie; Zheng, Tongzhang; Bai, Yana

doi:10.1016/j.jdiacomp.2016.07.022

Cited by 37 publications

(26 citation statements)

References 38 publications

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“…In the study of IFG, people whose blood glucose was greater than or equal to 7.0 mmol/L in the physical examination were excluded, and the people in the remaining cohort whose blood glucose was greater than or equal to 5.6 mmol/L were defined as having IFG. All study participants provided written informed consent, and the study protocol was approved by the Ethics Committees of Workers' Hospital of the Jinchang Industry and the Ethics Committees of the Public Health School of Lanzhou University …”

Section: Methodsmentioning

confidence: 99%

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Assessing different anthropometric indices and their optimal cutoffs for prediction of type 2 diabetes and impaired fasting glucose in Asians: The Jinchang Cohort Study

Ding

Chen

Bao

et al. 2019

Journal of Diabetes

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Background: To study the association between anthropometric measurements and the risk of diabetes and impaired fasting glucose (IFG) and compare body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) to determine the best indicator and its optimal cutoffs for predicting type 2 diabetes and IFG.Methods: A Chinese prospective (2011-2019) cohort named the Jingchang cohort that included 48 001 participants was studied. Using Cox proportional hazard models, hazard ratios (HRs) for incident type 2 diabetes or IFG per 1 SD change in BMI, WC, and WHtR were calculated. Area under the curve (AUC) was compared to identify the best anthropometric variable and its optimal cutoff for predicting diabetes. Results: The association of BMI, WC, and WHtR with type 2 diabetes or IFG risk was positive in the univariate and multivariable-adjusted Cox proportional hazard models. Of all three indexes, the AUC of BMI was largest and that of WC was smallest. The derived cutoff values for BMI, WC, and WHtR were 24.6 kg/m 2 , 89.5 cm, and 0.52 in men and 23.4 kg/m 2 , 76.5 cm, and 0.47 in women for predicting diabetes, respectively. The derived cutoff values for BMI, WC, and WHtR were 23.4 kg/m 2 , 87.5 cm, and 0.50 in men and 22.5 kg/m 2 , 76.5 cm, and 0.47 in women for predicting IFG, respectively [Correction added on 8 April 2020, after first online publication: '0' has been deleted from 'WC,0' in the first sentence.].Conclusions: Our derived cutoff points were lower than the values specified in the most current Asian diabetes guidelines. We recommend a cutoff point for BMI in Asians of 23 kg/m 2 and for WC a cutoff point of 89 cm in men and

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Section: Methodsmentioning

confidence: 99%

“…All study participants provided written informed consent, and the study protocol was approved by the Ethics Committees of Workers' Hospital of the Jinchang Industry and the Ethics Committees of the Public Health School of Lanzhou University. 17…”

Section: Study Populationmentioning

confidence: 99%

Assessing different anthropometric indices and their optimal cutoffs for prediction of type 2 diabetes and impaired fasting glucose in Asians: The Jinchang Cohort Study

Ding

Chen

Bao

et al. 2019

Journal of Diabetes

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“…The company is the third largest nickel and second largest cobalt manufacturing enterprise in the world, and more than 90% of the nickel-group metals in China come from the company [ 20 ]. We began the baseline survey in June 2011 and finished it in December 2013, after which all workers in the cohort participated in in-person interviews, comprehensive physical exams, lab-based tests, and biosample collection every other year [ 21 ]. Data were collected with a questionnaire, and a physical examination was performed by clinicians at the Workers’ Hospital of JNMC [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Reproductive Factors and Risk of Spontaneous Abortion in the Jinchang Cohort

Miao

Bai

et al. 2018

IJERPH

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The aim of this study was to investigate the association between female reproductive status and risk of spontaneous abortion among female workers in the Jinchang Cohort. This study used data obtained from a baseline survey of the Jinchang Cohort Study of female workers in Jinchang Industry, the largest nickel production company in China. A standardized, structured questionnaire was used to collect the health status of 18,834 female workers employed by the company from 2011 to 2013. Spearman grade correlation analysis and logistic regression models were used to evaluate the association between female reproductive status and risk of spontaneous abortion. The incidence rate of spontaneous abortion was 6.89%, and fatigue was associated with the risk of spontaneous abortion. The number of pregnancies, age at primary birth and age at the last pregnancy were associated with an increased risk of spontaneous abortion (rs = 0.190, p = 0.000; rs = 0.092, p = 0.000; rs = 0.061, p = 0.000; respectively). In addition, there was a negative correlation between the number of artificial abortions and spontaneous abortions (rs = −0.129, p = 0.000). Female reproductive status was associated with an increased risk of spontaneous abortion in this cohort. More studies are needed to confirm this observed association.

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“…19 The strongest risk for T2D was observed among the smelting/refining male workers who also consumed the highest amount of tobacco or alcohol, suggesting that the magnitude of the T2D risk could be reduced in male workers if lifestyle modifications related to tobacco and alcohol use were undertaken. 17,18 Sulphur dioxide exposure was found to be associated with earlier mean age at natural menopause in non-office workers in the cohort. 16 Reproductive factors such as age at menarche, age at menopause and reproductive life span, were associated with increased risk of T2D in women of the cohort.…”

Section: What Has It Found? Key Findings and Publicationsmentioning

confidence: 86%

“…Some of results based on the baseline data of the cohort have also been published. [15][16][17][18][19][20][21][22] The prevalence of metabolic syndrome (MetS), overweight and hyperlipidaemia was high in the occupational workers of the cohort, in particular among male workers. 20 Occupations associated with higher levels of metal exposures were related to increased risk of T2D among those workers.…”

Section: What Has It Found? Key Findings and Publicationsmentioning

confidence: 99%